Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KS6A3_HUMAN
Description:ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Source:HGNC Symbol;Acc:10432]
Location:chrX p22.12
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T365EFTAKtPKDSPPkinase_CPhosphoSitePlus
S227EKKAYsFCGTVphosphoELM; RegPhos; SysPTM
T231YSFCGtVEYMAphosphoELM; RegPhos
Y226HEKKAySFCGTphosphoELM
Y483TLKDVyDDGKYPkinase; tRNA-synt_1fPhosphoSitePlus
Y707AMAATySALNRPhosphoSitePlus; HPRD; RegPhos
Y488YDDGKyVYVVTPkinase; tRNA-synt_1fPhosphoSitePlus
T231YSFCGtVEYMAPkinasePhosphoSitePlus
S78VLGQGsFGKVFHPRD
S715LNRNQsPVLEPPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S227EKKAYsFCGTVRPS6KA3HPRD; SysPTM
S78VLGQGsFGKVFPkinasePhosphoSitePlus
S369KTPKDsPGIPPRPS6KA3HPRD; SysPTM
T577NGLLMtPCYTAPkinasePhosphoSitePlus
S369KTPKDsPGIPPPkinase_CPhosphoSitePlus; SysPTM
Y470EILLRyGQHPNPkinase; tRNA-synt_1fPhosphoSitePlus
S715LNRNQsPVLEPRPS6KA3HPRD; SysPTM
Y488YDDGKyVYVVTFGFR_groupphosphoELM
T706GAMAAtYSALNHPRD
Y547PSNILyVDESGPkinase; tRNA-synt_1fPhosphoSitePlus
S737IKKITsTALRegPhos
S517SEREAsAVLFTPkinase; tRNA-synt_1fPhosphoSitePlus
Y529TKTVEyLHAQGPkinase; tRNA-synt_1fPhosphoSitePlus
T362FDPEFtAKTPKPkinase_CPhosphoSitePlus
S375PGIPPsANAHQPkinase_CPhosphoSitePlus
Y644SLSGGyWNSVSPkinasePhosphoSitePlus
Y234CGTVEyMAPEVPkinasePhosphoSitePlus
Y488YDDGKyVYVVTphosphoELM
S415QLHRNsIQFTDPhosphoSitePlus; HPRD; SysPTM
Y356PEDTFyFDPEFHPRD
T365EFTAKtPKDSPphosphoELM; RegPhos
T577NGLLMtPCYTARegPhos
S556SGNPEsIRICDHPRD; SysPTM
T581MTPCYtANFVAPkinasePhosphoSitePlus
S386LFRGFsFVAITPkinase_CPhosphoSitePlus; SysPTM
Y226HEKKAySFCGTPkinasePhosphoSitePlus
Y144TEGKLyLILDFPkinasePhosphoSitePlus
T577NGLLMtPCYTAMAPK3phosphoELM
T581MTPCYtANFVARPS6KA3HPRD
S386LFRGFsFVAITHPRD; phosphoELM; RegPhos; SysPTM
S392FVAITsDDESQPhosphoSitePlus
Y356PEDTFyFDPEFPkinase_CPhosphoSitePlus
S556SGNPEsIRICDPkinase; tRNA-synt_1fPhosphoSitePlus; SysPTM
S375PGIPPsANAHQHPRD; phosphoELM
Y688DQLPQyQLNRQPhosphoSitePlus
S369KTPKDsPGIPPHPRD; phosphoELM; RegPhos; SysPTM
T365EFTAKtPKDSPRPS6KA3HPRD
T577NGLLMtPCYTAErk1(MAPK3RegPhos
T391SFVAItSDDESPhosphoSitePlus
S17KMAVEsPSDSAPhosphoSitePlus; HPRD; phosphoELM
Y433IGVGSySVCKRPkinasePhosphoSitePlus
Y707AMAATySALNRFGFR1phosphoELM; RegPhos
T625NGPDDtPEEILPkinasePhosphoSitePlus
S227EKKAYsFCGTVPkinasePhosphoSitePlus; SysPTM
T278RKETMtMILKAPkinasePhosphoSitePlus
T231YSFCGtVEYMARPS6KA3HPRD
S19AVESPsDSAENPhosphoSitePlus
S708MAATYsALNRNPhosphoSitePlus
T362FDPEFtAKTPKHPRD
Y580LMTPCyTANFVPkinasePhosphoSitePlus

Dephosphorylation site
KS6A3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000368884L608FGreenman2007, HPINeoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000368884L608FGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000368884Q400HBIOMARTBreast Cancer21930507, 21930502
ENSP00000368884I416VSjoblom2006, HPI, BIOMARTBreast Cancer16959974, 21930507, 21930502
ENSP00000368884Y483CGreenman2007, HPIGastric Cancer17344846, 18428421

Differential expressed protein
KS6A3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KS6A3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KS6A3_HUMANNR4A1_HUMANkinase -> substrateHPRD; RegPhos
KS6A3_HUMANATF4_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KS6A3_HUMANKS6A3_HUMANkinase -> substrateHPRD
KS6A3_HUMAN2AAA_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANKS6A3_HUMANkinase -> substrateRegPhos
KS6A3_HUMANHMGN2_HUMANkinase -> substrateRegPhos
KS6A3_HUMANK1C18_HUMANkinase -> substrateHPRD; RegPhos
KS6A3_HUMANCREB1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
KS6A3_HUMANRRN3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK03_HUMANKS6A3_HUMANkinase -> substrateRobert H Newman (2013)
KS6A3_HUMANPPR3A_HUMANkinase -> substrateRegPhos
KS6A3_HUMANSTK11_HUMANkinase -> substrateHPRD; RegPhos
KS6A3_HUMANDAPK1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KS6A3_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A3_HUMANCDN1B_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KS6A3_HUMANP53_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KS6A3_HUMANH31T_HUMANkinase -> substrateHPRD; RegPhos
KS6A3_HUMANESR1_HUMANkinase -> substrateHPRD; RegPhos
KS6A3_HUMANTAU_HUMANkinase -> substrateHPRD; RegPhos
KS6A3_HUMANNFAC4_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
FGFR1_HUMANKS6A3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KS6A3_HUMANHMGN1_HUMANkinase -> substrateRegPhos
KS6A3_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
KS6A3_HUMANFOS_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04722Neurotrophin signaling pathway
hsa04114Oocyte meiosis
hsa04914Progesterone-mediated oocyte maturation
hsa04150mTOR signaling pathway
hsa04720Long-term potentiation
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043555regulation of translation in response to stressTASbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0043027cysteine-type endopeptidase inhibitor activity invIDAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005840ribosomeIEAcellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0043620regulation of DNA-dependent transcription in respoTASbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0008063Toll signaling pathwayTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0043066negative regulation of apoptotic processTASbiological_process
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0007049cell cycleIEAbiological_process
GO:0004672protein kinase activityTASmolecular_function
GO:0002224toll-like receptor signaling pathwayIEAbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0007417central nervous system developmentTASbiological_process
GO:0043154negative regulation of cysteine-type endopeptidaseIDAbiological_process
GO:0030307positive regulation of cell growthTASbiological_process
GO:0001501skeletal system developmentTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0019901protein kinase bindingIEAmolecular_function
GO:0045087innate immune responseTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0045597positive regulation of cell differentiationTASbiological_process
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process