| UniProt/SwissProt ID: | PAX5_HUMAN |
| Description: | paired box 5 [Source:HGNC Symbol;Acc:8619] |
| Location: | chr9 p13.2 |
| Node attribute: | gene; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S206 | EGIQEsPVPNG | PhosphoSitePlus | |
| S168 | SVTQVsSVSTD | PhosphoSitePlus | |
| Y299 | PGPQSyPIVTG | PhosphoSitePlus | |
| Y73 | ILGRYyETGSI | PAX | PhosphoSitePlus |
| Y7 | DLEKNyPTPRT | PhosphoSitePlus | |
| S180 | AGSSYsISGIL | PhosphoSitePlus | |
| S298 | VPGPQsYPIVT | PhosphoSitePlus | |
| Y179 | SAGSSySISGI | PhosphoSitePlus | |
| Dephosphorylation site |
| PAX5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000350844 | R59G | COSMIC | Lymphoma | 19129520 | ENSP00000350844 | Y346C | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000350844 | V151I | COSMIC | Lymphoma | 19129520 | ENSP00000350844 | V26G | COSMIC | Lymphoma | 17344859 | ENSP00000350844 | G314W | COSMIC | Lung Cancer | 20668451 | ENSP00000350844 | G24R | COSMIC | Lymphoma | 19129520 | ENSP00000350844 | D53V | COSMIC | Lymphoma | 19129520 | ENSP00000350844 | P80R | COSMIC | Lymphoma | 19129520 | ENSP00000350844 | P320L | COSMIC | Lung Cancer | 20668451 | ENSP00000350844 | P34Q | COSMIC | Lymphoma | 17344859 | ENSP00000350844 | I301T | COSMIC | Lymphoma | 19129520 | ENSP00000350844 | I139T | COSMIC | Lymphoma | 19129520 | ENSP00000350844 | N355H | COSMIC | Lung Cancer | 20668451 | ENSP00000350844 | T75R | COSMIC | Lymphoma | 19129520 | ENSP00000350844 | S213L | COSMIC | Lymphoma | 19129520 | ENSP00000350844 | G338W | COSMIC | Lymphoma | 17344859 |
| Differential expressed protein |
| PAX5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PAX5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PAX5_HUMAN | CD19_HUMAN | TF -> target gene | TRANSFAC |
| PRDM1_HUMAN | PAX5_HUMAN | TF -> target gene | TRANSFAC |
| PAX5_HUMAN | P53_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| PAX5_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007275 | multicellular organismal development | TAS | biological_process |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0007283 | spermatogenesis | IEA | biological_process |
| GO:0007399 | nervous system development | IEA | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0006959 | humoral immune response | TAS | biological_process |
| GO:0009887 | organ morphogenesis | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0051573 | negative regulation of histone H3-K9 methylation | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0030154 | cell differentiation | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |