| UniProt/SwissProt ID: | CDK4_HUMAN |
| Description: | cyclin-dependent kinase 4 [Source:HGNC Symbol;Acc:1773] |
| Location: | chr12 q14.1 |
| Node attribute: | substrate; kinase; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T172 | YQMALtPVVVT | Pkinase | PhosphoSitePlus |
| T172 | YQMALtPVVVT | CDK7 | phosphoELM; RegPhos |
| T172 | YQMALtPVVVT | HPRD; RegPhos | |
| Y17 | IGVGAyGTVYK | Pkinase | PhosphoSitePlus |
| T172 | YQMALtPVVVT | DDR1(CAK) | RegPhos |
| Dephosphorylation site |
| CDK4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| CDK4_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000257904 | Hepatocellular Carcinoma | Metastasis | cell line | Up | 1.5 | 19016532 |
| Hyperphosphorylation site |
| CDK4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK4_HUMAN | CSRP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | SF3B1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | CENPS_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | SRC8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | CBL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | LRIG1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | KAP0_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | UBB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | SPN1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | NFAC3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | CDKA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | RBBP9_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | PRS6A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | QKI_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | IRF3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DDR1_HUMAN | CDK4_HUMAN | kinase -> substrate | RegPhos |
| CDK4_HUMAN | KDM4C_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | RFA2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | G3P_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | M18BP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | PKNX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | EXOS5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | ZMYM3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | MDM4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | RUVB1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | CDK4_HUMAN | kinase -> substrate | RegPhos |
| CDK4_HUMAN | KHDR1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | UBF1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| CDK4_HUMAN | RBL1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| CDK4_HUMAN | FAP24_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | ORC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | DDX25_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | RFA4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | PDCD5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | IF4B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | IASPP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | RPAC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | CSDC2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | 2A5A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | SMRC2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | CSDE1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | MBNL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | HNRPK_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | SRA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | BCL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | PHB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | KPYM_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | HSFX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | NU133_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | RBL2_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| CDK4_HUMAN | RB_HUMAN | kinase -> substrate | RegPhos; NetPath |
| CDK4_HUMAN | SMAD4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | ANX11_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | ID4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | SPAG7_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | ZN221_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | 4ET_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | VHL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | PDCD2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | XRCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | STON1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | ZIC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | FOXN2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | MTA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | PDIP2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | GPBP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | SMAD3_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| CDK4_HUMAN | KDM5D_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | ZN184_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | EP400_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | DDX4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | MCM7_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | PRDX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | NUP53_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | ORC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | ZBED1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | ZBT44_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | XPO1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK7_HUMAN | CDK4_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| CDK4_HUMAN | ARI2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | FOXF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | ERF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | CTBP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | ETS1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | DD19B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | NUCL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | NDF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | NOL7_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | NFAC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | ZN606_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MPIP1_HUMAN | CDK4_HUMAN | phosphatase -> substrate | KEGG |
| MYC_HUMAN | CDK4_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05162 | Measles |
| hsa05222 | Small cell lung cancer |
| hsa05219 | Bladder cancer |
| hsa05203 | Viral carcinogenesis |
| hsa04115 | p53 signaling pathway |
| hsa05218 | Melanoma |
| hsa05166 | HTLV-I infection |
| hsa05214 | Glioma |
| hsa04530 | Tight junction |
| hsa05220 | Chronic myeloid leukemia |
| hsa05212 | Pancreatic cancer |
| hsa04660 | T cell receptor signaling pathway |
| hsa05223 | Non-small cell lung cancer |
| hsa04110 | Cell cycle |
| hsa05200 | Pathways in cancer |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IMP | biological_process |
| GO:0045793 | positive regulation of cell size | IEA | biological_process |
| GO:0005829 | cytosol | IDA | cellular_component |
| GO:0010033 | response to organic substance | IEA | biological_process |
| GO:0000785 | chromatin | IDA | cellular_component |
| GO:0005667 | transcription factor complex | IEA | cellular_component |
| GO:0043065 | positive regulation of apoptotic process | IEA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0032403 | protein complex binding | IEA | molecular_function |
| GO:0030332 | cyclin binding | IEA | molecular_function |
| GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | IEA | cellular_component |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0031965 | nuclear membrane | IDA | cellular_component |
| GO:0009636 | response to toxin | IEA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0055093 | response to hyperoxia | IEA | biological_process |
| GO:0042127 | regulation of cell proliferation | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0010468 | regulation of gene expression | IMP | biological_process |
| GO:0000084 | S phase of mitotic cell cycle | TAS | biological_process |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0005923 | tight junction | IEA | cellular_component |
| GO:0042493 | response to drug | IGI | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0051726 | regulation of cell cycle | IEA | biological_process |
| GO:0008284 | positive regulation of cell proliferation | IEA | biological_process |
| GO:0004693 | cyclin-dependent protein kinase activity | IEA | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0010288 | response to lead ion | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0007623 | circadian rhythm | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0048146 | positive regulation of fibroblast proliferation | IMP | biological_process |
| GO:0000080 | G1 phase of mitotic cell cycle | TAS | biological_process |
| GO:0045727 | positive regulation of translation | IEA | biological_process |
| GO:0016301 | kinase activity | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0031100 | organ regeneration | IEA | biological_process |
| GO:0033574 | response to testosterone stimulus | IEA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005730 | nucleolus | IDA | cellular_component |
| GO:0006468 | protein phosphorylation | IEA | biological_process |