Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:STAT3_HUMAN
Description:signal transducer and activator of transcription 3 (acute-phase response factor) [Source:HGNC Symbol;Acc:11364]
Location:chr17 q21.2
Node attribute:PPI(source); acetylation(target); substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y705GSAAPyLKTKFEPHA3HPRD; SysPTM
Y79ESNVLyQHNLRSTAT_intPhosphoSitePlus
Y657EIIMGyKIMDAHPRD; RegPhos
Y704PGAAPyLKTKFFGFR4HPRD
Y704PGAAPyLKTKFFGFR3HPRD
T716CVTPTtCSNTIHPRD
Y704PGAAPyLKTKFSRCHPRD
Y704PGAAPyLKTKFHCKHPRD
S727IDLPMsPRTLDPKC_deltaphosphoELM
S727IDLPMsPRTLDMSK1RegPhos
S429ANCDAsLIVTESTAT_bindPhosphoSitePlus
S726IDLPMsPRTLDMAPK1HPRD
S726IDLPMsPRTLDMAPK3HPRD
S727IDLPMsPRTLDErk1RegPhos
Y686EAFGKyCRPESPhosphoSitePlus; HPRD
S726IDLPMsPRTLDHPRD
Y705GSAAPyLKTKFSRCHPRD; RegPhos; SysPTM
Y674PLVYLyPDIPKHPRD; RegPhos
Y704PGAAPyLKTKFJAK1HPRD
Y704PGAAPyLKTKFJAK2HPRD
T714KFICVtPTTCSPhosphoSitePlus; HPRD; phosphoELM
S726IDLPMsPRTLDRPS6KA5HPRD
S181YKTLKsQGDMQSyntaxin-6_N; STAT_alpha;PhosphoSitePlus
Y705GSAAPyLKTKFSrcRegPhos; SysPTM
S726IDLPMsPRTLDMAPK8HPRD
Y539GPGVNySGCQIHPRD
S727IDLPMsPRTLDPKCdRegPhos
T440ELHLItFETEVSTAT_bindPhosphoSitePlus
S727IDLPMsPRTLDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y705GSAAPyLKTKFJAK1HPRD; RegPhos; SysPTM
S727IDLPMsPRTLDJNK1RegPhos
T196NNQSVtRQKMQSTAT_alpha; Fib_alphaPhosphoSitePlus
Y705GSAAPyLKTKFPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T721TTCSNtIDLPMPhosphoSitePlus
Y539GPGVNySGCQISTAT_bindPhosphoSitePlus
S727IDLPMsPRTLDErk2RegPhos
S727IDLPMsPRTLDPRKCDHPRD
T717CVTPTtCSNTIHPRD; phosphoELM
S194NGNNQsVTRQKSTAT_alpha; Fib_alphaPhosphoSitePlus
Y705GSAAPyLKTKFHCKHPRD; RegPhos; SysPTM
T708APYLKtKFICVPhosphoSitePlus
S726IDLPMsPRTLDPRKCDHPRD
S719TPTTCsNTIDLPhosphoSitePlus
S691YCRPEsQEHPEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y705GSAAPyLKTKFRetRegPhos; SysPTM
T605TKPPGtFLLRFSH2PhosphoSitePlus
S540PGVNYsGCQITSTAT_bindPhosphoSitePlus
S701EADPGsAAPYLPhosphoSitePlus
Y704PGAAPyLKTKFHPRD
Y45SQDWAyAASKESTAT_intPhosphoSitePlus
T713KFICVtPTTCSHPRD
S727IDLPMsPRTLDMAPK1HPRD
S727IDLPMsPRTLDMAPK3HPRD
S727IDLPMsPRTLDMAPK8HPRD
Y674PLVYLyPDIPKSH2PhosphoSitePlus
Y705GSAAPyLKTKFFGFR4HPRD; RegPhos; SysPTM
Y705GSAAPyLKTKFFGFR3HPRD; RegPhos; SysPTM
Y705GSAAPyLKTKFALKphosphoELM; RegPhos; SysPTM
Y705GSAAPyLKTKFJAK2HPRD; phosphoELM; RegPhos; SysPTM
S727IDLPMsPRTLDRPS6KA5HPRD
Y446FETEVyHQGLKSTAT_bindPhosphoSitePlus
Y705GSAAPyLKTKFSrc_groupRegPhos; SysPTM
S727IDLPMsPRTLDIRAK1phosphoELM; RegPhos

Dephosphorylation site
STAT3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264657E63DCOSMICHead and Neck Cancer21798893
ENSP00000264657I589MCOSMICBreast Cancer20668451
ENSP00000264657G402CCOSMICLung Cancer18948947
ENSP00000384943G402CDing2008Lung Cancer18948947
ENSP00000264657A53GCOSMICOvarian Cancer21720365

Differential expressed protein
STAT3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y705DPGSAAPyLKTKFICbreast cancer18353781PhosphoSitePlus
S727NTIDLPMsPRTLDSLprostate cancer18829527PhosphoSitePlus
S727NTIDLPMsPRTLDSLmedullary thyroid carcinoma17209045PhosphoSitePlus
Y705DPGSAAPyLKTKFICglioblastoma20455003PhosphoSitePlus
Y705DPGSAAPyLKTKFICbladder cancer18939995PhosphoSitePlus
Y705DPGSAAPyLKTKFIChepatocellular carcinoma22153071PhosphoSitePlus
Y705DPGSAAPyLKTKFICfibrosarcoma of soft tissue21575192PhosphoSitePlus
Y705DPGSAAPyLKTKFICcolorectal carcinoma21166956PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
IRAK1_HUMANSTAT3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANSTAT3_HUMANkinase -> substrateRegPhos
JAK3_HUMANSTAT3_HUMANkinase -> substrateNetPath
JAK1_HUMANSTAT3_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANSTAT3_HUMANkinase -> substrateHPRD; RegPhos
MK08_HUMANSTAT3_HUMANkinase -> substrateHPRD; RegPhos
FGFR4_HUMANSTAT3_HUMANkinase -> substrateHPRD; RegPhos
EPHA3_HUMANSTAT3_HUMANkinase -> substrateHPRD
KS6A5_HUMANSTAT3_HUMANkinase -> substrateHPRD; RegPhos
MK01_HUMANSTAT3_HUMANkinase -> substrateHPRD; NetPath
MK03_HUMANSTAT3_HUMANkinase -> substrateHPRD; NetPath
KPCD_HUMANSTAT3_HUMANkinase -> substrateHPRD; NetPath
HCK_HUMANSTAT3_HUMANkinase -> substrateHPRD; RegPhos
FGFR3_HUMANSTAT3_HUMANkinase -> substrateHPRD; RegPhos
ALK_HUMANSTAT3_HUMANkinase -> substrateRegPhos
JAK2_HUMANSTAT3_HUMANkinase -> substrateKEGG; HPRD; RegPhos; Robert H Newman (2013)
RET_HUMANSTAT3_HUMANkinase -> substrateRobert H Newman (2013)
EP300_HUMANSTAT3_HUMANacetylationNetPath
STAT3_HUMANAAKG2_HUMANotherKEGG
STAT3_HUMANCOLI_HUMANotherKEGG
STAT3_HUMANCPT1C_HUMANTF -> target geneKEGG
STAT3_HUMANSOCS3_HUMANTF -> target geneKEGG
STAT3_HUMANPRGC1_HUMANTF -> target geneKEGG
STAT3_HUMANFOS_HUMANTF -> target geneTRANSFAC
STAT3_HUMANIRF1_HUMANTF -> target geneTRANSFAC
STAT3_HUMANTRH_HUMANTF -> target geneTRANSFAC
STAT3_HUMANCDN1A_HUMANTF -> target geneTRANSFAC
STAT3_HUMANPIM1_HUMANTF -> target geneTRANSFAC
STAT3_HUMANIL2RA_HUMANTF -> target geneTRANSFAC
STAT3_HUMANMYC_HUMANTF -> target geneTRANSFAC
STAT3_HUMANIL10_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05160Hepatitis C
hsa05212Pancreatic cancer
hsa04920Adipocytokine signaling pathway
hsa04062Chemokine signaling pathway
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa04630Jak-STAT signaling pathway
hsa05162Measles
hsa05221Acute myeloid leukemia
hsa05145Toxoplasmosis
hsa05203Viral carcinogenesis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019953sexual reproductionISSbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0034097response to cytokine stimulusIEAbiological_process
GO:0030522intracellular receptor mediated signaling pathwayIDAbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045747positive regulation of Notch signaling pathwayISSbiological_process
GO:0000981sequence-specific DNA binding RNA polymerase II trIEAmolecular_function
GO:0048708astrocyte differentiationIEAbiological_process
GO:0060019radial glial cell differentiationIEAbiological_process
GO:0007399nervous system developmentTASbiological_process
GO:0048708astrocyte differentiationISSbiological_process
GO:0005634nucleusIDAcellular_component
GO:0019221cytokine-mediated signaling pathwayNASbiological_process
GO:0007259JAK-STAT cascadeTASbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0001754eye photoreceptor cell differentiationIEAbiological_process
GO:0046983protein dimerization activityISSmolecular_function
GO:0060397JAK-STAT cascade involved in growth hormone signalISSbiological_process
GO:0005634nucleusIEAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0032355response to estradiol stimulusIDAbiological_process
GO:0032870cellular response to hormone stimulusIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0006606protein import into nucleusIDAbiological_process
GO:0019827stem cell maintenanceIEAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0035259glucocorticoid receptor bindingIEAmolecular_function
GO:0042755eating behaviorISSbiological_process
GO:0042493response to drugIEAbiological_process
GO:0003677DNA bindingISSmolecular_function
GO:0005886plasma membraneISScellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0001659temperature homeostasisISSbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0006357regulation of transcription from RNA polymerase IIISSbiological_process
GO:0060396growth hormone receptor signaling pathwayIDAbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0008134transcription factor bindingIPImolecular_function
GO:0006953acute-phase responseIEAbiological_process
GO:0006928cellular component movementTASbiological_process
GO:0005634nucleusISScellular_component
GO:0000122negative regulation of transcription from RNA polyTASbiological_process
GO:0060019radial glial cell differentiationISSbiological_process
GO:0007165signal transductionTASbiological_process
GO:0004879ligand-activated sequence-specific DNA binding RNAIDAmolecular_function
GO:0040014regulation of multicellular organism growthIEAbiological_process
GO:0042755eating behaviorIEAbiological_process
GO:0010033response to organic substanceIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0042593glucose homeostasisIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0001754eye photoreceptor cell differentiationISSbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0008283cell proliferationIEAbiological_process
GO:0001103RNA polymerase II repressing transcription factor IPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0046983protein dimerization activityIEAmolecular_function
GO:0031730CCR5 chemokine receptor bindingIEAmolecular_function
GO:0032355response to estradiol stimulusIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0019953sexual reproductionIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:0006366transcription from RNA polymerase II promoterIEAbiological_process
GO:0070102interleukin-6-mediated signaling pathwayIDAbiological_process
GO:0045747positive regulation of Notch signaling pathwayIEAbiological_process
GO:0043434response to peptide hormone stimulusIEAbiological_process
GO:0001659temperature homeostasisIEAbiological_process
GO:0005737cytoplasmISScellular_component
GO:0019901protein kinase bindingISSmolecular_function
GO:0019901protein kinase bindingIEAmolecular_function
GO:0042593glucose homeostasisISSbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signalIEAbiological_process
GO:0004871signal transducer activityTASmolecular_function