| UniProt/SwissProt ID: | TFDP1_HUMAN |
| Description: | transcription factor Dp-1 [Source:HGNC Symbol;Acc:11749] |
| Location: | chr13 q34 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S183 | AMNIIsKEKKE | RegPhos | |
| S23 | IDQNLsPGKGV | CDK2 | RegPhos |
| S183 | AMNIIsKEKKE | E2F_TDP | PhosphoSitePlus |
| S23 | IDQNLsPGKGV | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| TFDP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000364519 | E208* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000364519 | G115D | COSMIC | Ovarian Cancer | 21720365 | ENSP00000364519 | R168H | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000364519 | A5P | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000364519 | G113S | COSMIC | Skin Cancer | 21984974 | ENSP00000364519 | E208* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000364519 | G6V | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000364519 | G115D | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000364519 | V77A | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| TFDP1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TFDP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK2_HUMAN | TFDP1_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | TFDP1_HUMAN | kinase -> substrate | RegPhos |
| TFDP1_HUMAN | CAV1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04110 | Cell cycle |
| hsa04350 | TGF-beta signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006367 | transcription initiation from RNA polymerase II pr | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0000080 | G1 phase of mitotic cell cycle | TAS | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0008134 | transcription factor binding | IPI | molecular_function |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0007179 | transforming growth factor beta receptor signaling | TAS | biological_process |
| GO:0019904 | protein domain specific binding | IPI | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0045944 | positive regulation of transcription from RNA poly | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006357 | regulation of transcription from RNA polymerase II | TAS | biological_process |
| GO:0005667 | transcription factor complex | IEA | cellular_component |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0003713 | transcription coactivator activity | TAS | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |