Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MYOD1_HUMAN
Description:myogenic differentiation 1 [Source:HGNC Symbol;Acc:7611]
Location:chr11 p15.1
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S200DSDASsPRSNCCDC2(CDK1RegPhos
S200DSDASsPRSNCCDK_groupphosphoELM; RegPhos
T115RRKAAtMRERRPKC_groupphosphoELM; RegPhos
S214GMMDYsGPPSGMyf5PhosphoSitePlus
S5MELLSpPLRDCDC2(CDK1RegPhos
S5PLRDCDK1phosphoELM
Y213DGMMDySGPPSMyf5PhosphoSitePlus
T115RRKAAtMRERRHLHPhosphoSitePlus
T115RRKAAtMRERRPRKCAHPRD
S200GDSDAsSPRSNCDK2HPRD
S200DSDASsPRSNCCDK1phosphoELM
S200DSDASsPRSNCCDK2RegPhos
S204ASSPRsNCSDGMyf5PhosphoSitePlus
S207PRSNCsDGMMDMyf5PhosphoSitePlus
T115RRKAAtMRERRPKCaRegPhos

Dephosphorylation site
MYOD1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000250003A303SBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000250003E262KSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000250003A309VSjoblom2006, COSMIC, HPIBreast Cancer16959974

Differential expressed protein
MYOD1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MYOD1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK1_HUMANMYOD1_HUMANkinase -> substrateRegPhos
KPCA_HUMANMYOD1_HUMANkinase -> substrateHPRD
CDK2_HUMANMYOD1_HUMANkinase -> substrateHPRD; RegPhos
PKN1_HUMANMYOD1_HUMANkinase -> substrateRobert H Newman (2013)
MYOD1_HUMANFOS_HUMANTF -> target geneTRANSFAC
MYOD1_HUMANAKT2_HUMANTF -> target geneTRANSFAC
MYOD1_HUMANU627C_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
MYOD1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007519skeletal muscle tissue developmentTASbiological_process
GO:0051146striated muscle cell differentiationIEAbiological_process
GO:0043415positive regulation of skeletal muscle tissue regeIEAbiological_process
GO:0005667transcription factor complexISScellular_component
GO:0071385cellular response to glucocorticoid stimulusIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0043503skeletal muscle fiber adaptationIEAbiological_process
GO:1901741positive regulation of myoblast fusionIDAbiological_process
GO:0007519skeletal muscle tissue developmentIEAbiological_process
GO:0003713transcription coactivator activityTASmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005634nucleusTAScellular_component
GO:0055007cardiac muscle cell differentiationIEAbiological_process
GO:0019899enzyme bindingIEAmolecular_function
GO:0005667transcription factor complexIEAcellular_component
GO:0042693muscle cell fate commitmentISSbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0030016myofibrilIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0071453cellular response to oxygen levelsIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0014908myotube differentiation involved in skeletal musclIEAbiological_process
GO:0031625ubiquitin protein ligase bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0046983protein dimerization activityIEAmolecular_function
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0009267cellular response to starvationIEAbiological_process
GO:0007518myoblast cell fate determinationIEAbiological_process
GO:0045445myoblast differentiationIEAbiological_process
GO:0007517muscle organ developmentIEAbiological_process
GO:0070888E-box bindingISSmolecular_function
GO:0042692muscle cell differentiationTASbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiTASmolecular_function
GO:0007517muscle organ developmentTASbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0035914skeletal muscle cell differentiationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0043484regulation of RNA splicingIDAbiological_process
GO:0051149positive regulation of muscle cell differentiationIDAbiological_process
GO:0000381regulation of alternative mRNA splicing, via splicIEAbiological_process
GO:0048741skeletal muscle fiber developmentIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0046982protein heterodimerization activityISSmolecular_function
GO:0000790nuclear chromatinIEAcellular_component
GO:0014904myotube cell developmentIDAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0006468protein phosphorylationTASbiological_process
GO:0000790nuclear chromatinISScellular_component
GO:0005737cytoplasmIEAcellular_component