Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HNRPQ_HUMAN
Description:synaptotagmin binding, cytoplasmic RNA interacting protein [Source:HGNC Symbol;Acc:16918]
Location:chr6 q14.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S509RGAAPsRGRGAPhosphoSitePlus
Y472YDYYGyDYHNYPhosphoSitePlus
Y434DDYYYyGPPHMPhosphoSitePlus
S249RLFVGsIPKSKRRM_1PhosphoSitePlus
S249RLFVGsIPKSKHPRD
Y373KKLKDyAFIHFFGFR1phosphoELM; RegPhos
T580SKRRQtNNQNWPhosphoSitePlus
Y432MYDDYyYYGPPPhosphoSitePlus
S115TKVADsSKGPDPhosphoSitePlus
Y144TGQRKyGGPPPPhosphoSitePlus
Y570RKADGyNQPDSPhosphoSitePlus
S524GRAGYsQRGGPPhosphoSitePlus
Y373KKLKDyAFIHFRRM_1PhosphoSitePlus
S531RGGPGsARGVRPhosphoSitePlus
Y614ENQEFyQDTFGPhosphoSitePlus
S575YNQPDsKRRQTPhosphoSitePlus
S587NQNWGsQPIAQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y474YYGYDyHNYRGPhosphoSitePlus
Y485GYEDPyYGYEDPhosphoSitePlus
S116KVADSsKGPDEPhosphoSitePlus
Y373KKLKDyAFIHFRegPhos
Y431QMYDDyYYYGPPhosphoSitePlus
T110REKQGtKVADSPhosphoSitePlus

Dephosphorylation site
HNRPQ_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358635R533KCOSMICSkin Cancer21984974
ENSP00000358635E183QBIOMARTBreast Cancer21930507, 21930502
ENSP00000347380E183QBIOMARTBreast Cancer21930507, 21930502
ENSP00000358635I326MCOSMICSkin Cancer21984974
ENSP00000358635Y469CCOSMICOvarian Cancer21720365
ENSP00000358635E397KCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000358635Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.3318646787
ENSP00000358635hepatitis B virusNormal vs. CancertissueDown0.314726492
ENSP00000358635acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000358635acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000358635acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp617655343
ENSP00000358635acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343

Hyperphosphorylation site
HNRPQ_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANHNRPQ_HUMANkinase -> substrateRegPhos
FGFR1_HUMANHNRPQ_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
HNRPQ_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000398mRNA splicing, via spliceosomeICbiological_process
GO:0008143poly(A) RNA bindingIEAmolecular_function
GO:0005634nucleusTAScellular_component
GO:0070937CRD-mediated mRNA stability complexIDAcellular_component
GO:0070934CRD-mediated mRNA stabilizationIMPbiological_process
GO:0071346cellular response to interferon-gammaIDAbiological_process
GO:0006396RNA processingTASbiological_process
GO:0071204histone pre-mRNA 3'end processing complexIEAcellular_component
GO:0000166nucleotide bindingIEAmolecular_function
GO:0005654nucleoplasmIEAcellular_component
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0003723RNA bindingTASmolecular_function
GO:0019048virus-host interactionIEAbiological_process
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0030529ribonucleoprotein complexIDAcellular_component
GO:0071013catalytic step 2 spliceosomeIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0017148negative regulation of translationIMPbiological_process
GO:0008380RNA splicingTASbiological_process
GO:0005737cytoplasmIEAcellular_component


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