Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PRGR_HUMAN
Description:progesterone receptor [Source:HGNC Symbol;Acc:8910]
Location:chr11 q22.1
Node attribute:gene; substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S345APPRSsPCASSphosphoELM; RegPhos
S25SPEVGsPLLCRCDK2RegPhos
S81DQQSLsDVEGACK2a1RegPhos
T41FPGSQtSDTLPCK_groupRegPhos
S345APPRSsPCASSProg_receptorPhosphoSitePlus
S20AGGPPsPEVGSProg_receptorPhosphoSitePlus
T430LPPRAtPSRPGCDK2RegPhos
S554SEASQsPQYSFProg_receptorPhosphoSitePlus
S102GGSSSsPPEKDphosphoELM; RegPhos
S552PDSEAsQSPQYProg_receptorPhosphoSitePlus
S549YLRPDsEASQSProg_receptorPhosphoSitePlus
S213APVKPsPQAAAProg_receptorPhosphoSitePlus
S294MAPGRsPLATTErk1(MAPK3RegPhos
S130GQSQPsPPACEphosphoELM; RegPhos
S190LPRGLsPARQLCDK2phosphoELM; RegPhos
S213APVKPsPQAAACDK2phosphoELM; RegPhos
S162TQRVLsPLMSRProg_receptorPhosphoSitePlus; SysPTM
S81DQQSLsDVEGACK2a1-rsRegPhos
S561QYSFEsLPQKIProg_receptorPhosphoSitePlus
S558QSPQYsFESLPProg_receptorPhosphoSitePlus
S232SESEEsAGPLLCK_groupRegPhos
S294MAPGRsPLATTProg_receptorPhosphoSitePlus
S400EASARsPRSYLProg_receptorPhosphoSitePlus
S676QRFTFsPGQDIPhosphoSitePlus; RegPhos
S400EASARsPRSYLCDK2phosphoELM; RegPhos
S294MAPGRsPLATTphosphoELM
Y87DVEGAySRAEAProg_receptorPhosphoSitePlus
S20AGGPPsPEVGSphosphoELM; RegPhos
S190LPRGLsPARQLRegPhos
S130GQSQPsPPACEProg_receptorPhosphoSitePlus
S676QRFTFsPGQDICDK2phosphoELM; RegPhos
S793RMKESsFYSLCCK_groupRegPhos
S162TQRVLsPLMSRCDK2phosphoELM; RegPhos; SysPTM
S81DQQSLsDVEGACK2_alphaphosphoELM
S81DQQSLsDVEGAProg_receptorPhosphoSitePlus
S81DQQSLsDVEGACK2a1(CK2 alphaRegPhos
S102GGSSSsPPEKDProg_receptorPhosphoSitePlus
S88VEGAYsRAEATProg_receptorPhosphoSitePlus
S294MAPGRsPLATTMAPK1phosphoELM
S81DQQSLsDVEGACK2_groupphosphoELM; RegPhos
S294MAPGRsPLATTErk2(MAPK1RegPhos
S213APVKPsPQAAARegPhos
S81DQQSLsDVEGACSNK2A1HPRD
S294MAPGRsPLATTMAPK3phosphoELM
S227EEEDGsESEESCK_groupRegPhos
S554SEASQsPQYSFCDK2RegPhos
S162TQRVLsPLMSRHPRD; phosphoELM; RegPhos; SysPTM
S190LPRGLsPARQLProg_receptorPhosphoSitePlus
S552PDSEAsQSPQYCK_groupRegPhos

Dephosphorylation site
PRGR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000325120V184MCOSMICCentral Nervous System Neoplasms18772890
ENSP00000325120D697YCOSMICLung Cancer
ENSP00000325120I751FCOSMICOvarian Cancer21720365
ENSP00000325120R899LBIOMARTBreast Cancer21930507, 21930502
ENSP00000325120R740QCOSMICHepatocellular Carcinoma
ENSP00000325120P657SCOSMICHead and Neck Cancer21798893

Differential expressed protein
PRGR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PRGR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANPRGR_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK01_HUMANPRGR_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANPRGR_HUMANkinase -> substrateRegPhos
CDK2_HUMANPRGR_HUMANkinase -> substrateRegPhos
MK03_HUMANPRGR_HUMANkinase -> substrateRobert H Newman (2013)
PRGR_HUMANIBP1_HUMANTF -> target geneTRANSFAC
ESR1_HUMANPRGR_HUMANTF -> target geneTRANSFAC
PRGR_HUMANGNRHR_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04114Oocyte meiosis
hsa04914Progesterone-mediated oocyte maturation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043401steroid hormone mediated signaling pathwayIEAbiological_process
GO:0005496steroid bindingIEAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0005102receptor bindingIPImolecular_function
GO:0010467gene expressionTASbiological_process
GO:0004879ligand-activated sequence-specific DNA binding RNAIEAmolecular_function
GO:0002070epithelial cell maturationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007267cell-cell signalingTASbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0019899enzyme bindingIPImolecular_function
GO:0003677DNA bindingTASmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0050847progesterone receptor signaling pathwayIEAbiological_process
GO:0060748tertiary branching involved in mammary gland duct IEAbiological_process
GO:0050678regulation of epithelial cell proliferationIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0010629negative regulation of gene expressionIEPbiological_process
GO:0007165signal transductionTASbiological_process
GO:0001542ovulation from ovarian follicleIEAbiological_process
GO:0030879mammary gland developmentIEAbiological_process
GO:0003707steroid hormone receptor activityIEAmolecular_function
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process