Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KS6A1_HUMAN
Description:ribosomal protein S6 kinase, 90kDa, polypeptide 1 [Source:HGNC Symbol;Acc:10430]
Location:chr1 p36.11
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S154LFTRLsKEVMFHPRD; RegPhos
S54HVKAGsEKADPPhosphoSitePlus
T368EFTSRtPKDSPMAPK1HPRD
S389LFRGFsFVATGRPS6KA1HPRD
T348AQPDDtFYFDTRegPhos
T742RKLPStHPRD
T582NGLLMtPCYTAHPRD
Y585LMTPCyTANFVHPRD
T586MTPCYtANFVAHPRD
T359EFTSRtPKDSPMAPK1HPRD
S380LFRGFsFVATGPkinase_CPhosphoSitePlus; SysPTM
S363RTPKDsPGIPPMAPK_groupphosphoELM; RegPhos; SysPTM
T234YSFCGtVEYMAHPRD
Y576LMTPCyTANFVPkinase_AGCPhosphoSitePlus
S732VRKLPsTTLRegPhos; SysPTM
T577MTPCYtANFVAPkinase_AGCPhosphoSitePlus
Y228CGTVEyMAPEVPkinase_AGCPhosphoSitePlus
S378PGIPPsAGAHQHPRD
S402QAPLHsVVQQLPhosphoSitePlus
T522HTIGKtVEYLHPkinase_AGCPhosphoSitePlus
S369PGIPPsAGAHQPkinase_CPhosphoSitePlus
T225YSFCGtVEYMAHPRD; phosphoELM; RegPhos
S369PGIPPsAGAHQHPRD; phosphoELM; RegPhos
S221EKKAYsFCGTVPkinase_AGCPhosphoSitePlus
S363RTPKDsPGIPPphosphoELM; RegPhos; SysPTM
S637GKFTLsGGNWNPkinase_AGCPhosphoSitePlus
T573NGLLMtPCYTAHPRD; phosphoELM; RegPhos; SysPTM
S741VRKLPsTHPRD
Y229HEKKAySFCGTHPRD
T359EFTSRtPKDSPphosphoELM; RegPhos
Y138TEGKLyLILDFPkinase_AGCPhosphoSitePlus
S363RTPKDsPGIPPMAPK1HPRD; SysPTM
Y466EILLRyGQHPNPkinase_AGCPhosphoSitePlus
S372RTPKDsPGIPPMAPK1HPRD
T234YSFCGtVEYMARPS6KA1HPRD
S163LFTRLsKEVMFHPRD
T701GAMAAtYSALNPhosphoSitePlus
Y91DSGHLyAMKVLPkinase_AGCPhosphoSitePlus
S209TDFGLsKEAIDPkinase_AGCPhosphoSitePlus
S221EKKAYsFCGTVRSK_groupphosphoELM; RegPhos
S380LFRGFsFVATGautocatalysisRegPhos; SysPTM
S221EKKAYsFCGTVphosphoELM; RegPhos
T577MTPCYtANFVAHPRD; phosphoELM
Y220HEKKAySFCGTHPRD; phosphoELM
S684DKLPQsQLSHQPhosphoSitePlus
S703MAATYsALNSSPhosphoSitePlus
Y702AMAATySALNSPhosphoSitePlus
S221EKKAYsFCGTVPDK1RegPhos
S380LFRGFsFVATGRSK3RegPhos; SysPTM
T733RKLPStTL___PhosphoSitePlus
S732VRKLPsTTL__PhosphoSitePlus; SysPTM
S732VRKLPsTHPRD; phosphoELM; SysPTM
S363RTPKDsPGIPPPkinase_CPhosphoSitePlus; SysPTM
Y228CGTVEyMAPEVHPRD
T359EFTSRtPKDSPMAPK_groupphosphoELM; RegPhos
T25PENGQtSGEEAHPRD
S230EKKAYsFCGTVPDPK1HPRD
T359EFTSRtPKDSPErk2RegPhos
S221EKKAYsFCGTVPDK-1phosphoELM
T359EFTSRtPKDSPPkinase_CPhosphoSitePlus
S72VLGQGsFGKVFPkinase_AGCPhosphoSitePlus
T586MTPCYtANFVARPS6KA1HPRD
S307ANRLGsGPDGAPkinase_AGCPhosphoSitePlus
T577MTPCYtANFVARPS6KA1HPRD
T573NGLLMtPCYTAPkinase_AGCPhosphoSitePlus; SysPTM
S380LFRGFsFVATGphosphoELM; RegPhos; SysPTM
T733RKLPStHPRD; phosphoELM
S363RTPKDsPGIPPErk2RegPhos; SysPTM
T225YSFCGtVEYMAPkinase_AGCPhosphoSitePlus
S380LFRGFsFVATGRPS6KA1HPRD; SysPTM
S221EKKAYsFCGTVPDPK1HPRD
Y220HEKKAySFCGTPkinase_AGCPhosphoSitePlus
Y237CGTVEyMAPEVHPRD
T225YSFCGtVEYMARPS6KA1HPRD
Y576LMTPCyTANFVHPRD

Dephosphorylation site
KS6A1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000435412V457ICOSMICLung Cancer20668451
ENSP00000435412Q414RCOSMICOvarian Cancer21720365
ENSP00000435412Q414RTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000431651Gastric CancerMetastasiscell lineDown0.3917022644
ENSP00000431651Gastric CancerMetastasiscell lineDown0.3917022644
ENSP00000431651Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.5415169874

Hyperphosphorylation site
KS6A1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KS6A1_HUMANEF2K_HUMANkinase -> substrateHPRD
KS6A1_HUMANRXRG_HUMANkinase -> substrateRobert H Newman (2013)
KS6A1_HUMANETV1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KS6A1_HUMANVCAM1_HUMANkinase -> substrateHPRD; RegPhos
KS6A1_HUMANFOS_HUMANkinase -> substrateHPRD
KS6A1_HUMANIKBB_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KS6A1_HUMANNR4A2_HUMANkinase -> substrateHPRD
KS6A1_HUMANESR1_HUMANkinase -> substrateHPRD
KS6A1_HUMANTSC2_HUMANkinase -> substrateHPRD
ZAGL2_HUMANKS6A1_HUMANkinase -> substrateRegPhos
KS6A1_HUMANIKBA_HUMANkinase -> substrateHPRD
MK01_HUMANKS6A1_HUMANkinase -> substrateHPRD
KS6A1_HUMANESR2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KS6A1_HUMANGMFB_HUMANkinase -> substrateHPRD
KS6A1_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
KS6A1_HUMANKS6A1_HUMANkinase -> substrateHPRD
KS6A1_HUMANMITF_HUMANkinase -> substrateNetPath
KS6A1_HUMANCEBPB_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
KS6A1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A1_HUMANMK01_HUMANkinase -> substrateRobert H Newman (2013)
KS6A1_HUMANTRMB_HUMANkinase -> substrateHPRD
KS6A1_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
KS6A1_HUMANPPR3A_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
KS6A1_HUMANCREB1_HUMANkinase -> substrateHPRD; RegPhos; NetPath
KS6A1_HUMANMTOR_HUMANkinase -> substrateHPRD
KS6A1_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
KS6A1_HUMANNR4A3_HUMANkinase -> substrateHPRD
KS6A1_HUMANNR4A1_HUMANkinase -> substrateHPRD
KS6A1_HUMANSRF_HUMANkinase -> substrateHPRD
KS6A1_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
KS6A1_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
KS6A1_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANKS6A1_HUMANkinase -> substrateNetPath
KS6A2_HUMANKS6A1_HUMANkinase -> substrateRegPhos
PDPK1_HUMANKS6A1_HUMANkinase -> substrateHPRD; RegPhos
KS6A1_HUMANBAD_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04722Neurotrophin signaling pathway
hsa04150mTOR signaling pathway
hsa04720Long-term potentiation
hsa04914Progesterone-mediated oocyte maturation
hsa04114Oocyte meiosis
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0043027cysteine-type endopeptidase inhibitor activity invIDAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0043154negative regulation of cysteine-type endopeptidaseIDAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0005819spindleIEAcellular_component
GO:0030307positive regulation of cell growthTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:2000491positive regulation of hepatic stellate cell activIMPbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0043555regulation of translation in response to stressTASbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0007049cell cycleIEAbiological_process
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0045087innate immune responseTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0043620regulation of DNA-dependent transcription in respoTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0045597positive regulation of cell differentiationTASbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process


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