Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	THA_HUMAN
Description:	thyroid hormone receptor, alpha [Source:HGNC Symbol;Acc:11796]
Location:	chr17 q21.1
Node attribute:	PPI(target); substrate; TF

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
S450	ELLHRsGILHA		PhosphoSitePlus

Dephosphorylation site

THA_HUMAN do not have dephosphorylation site.

Mutation site

THA_HUMAN do not have mutation site.

Differential expressed protein

THA_HUMAN is not differential expressed protein.

Hyperphosphorylation site

THA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
AKT1_HUMAN	THA_HUMAN	kinase -> substrate	Robert H Newman (2013)
ERCC8_HUMAN	THA_HUMAN	other	KEGG
THA_HUMAN	TSHB_HUMAN	TF -> target gene	TRANSFAC

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa04080	Neuroactive ligand-receptor interaction

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0005515	protein binding	IPI	molecular_function
GO:0005829	cytosol	IDA	cellular_component
GO:0070324	thyroid hormone binding	IPI	molecular_function
GO:0001503	ossification	IEA	biological_process
GO:0032403	protein complex binding	IEA	molecular_function
GO:0004879	ligand-activated sequence-specific DNA binding RNA	IEA	molecular_function
GO:0006366	transcription from RNA polymerase II promoter	IDA	biological_process
GO:0006357	regulation of transcription from RNA polymerase II	IDA	biological_process
GO:2000143	negative regulation of DNA-dependent transcription	IDA	biological_process
GO:0030218	erythrocyte differentiation	IEA	biological_process
GO:0017025	TBP-class protein binding	IDA	molecular_function
GO:0003700	sequence-specific DNA binding transcription factor	IDA	molecular_function
GO:0005634	nucleus	IEA	cellular_component
GO:0042994	cytoplasmic sequestering of transcription factor	IEA	biological_process
GO:0003727	single-stranded RNA binding	IEA	molecular_function
GO:0005515	protein binding	IEA	molecular_function
GO:0030522	intracellular receptor mediated signaling pathway	IEA	biological_process
GO:0001502	cartilage condensation	IEA	biological_process
GO:0008134	transcription factor binding	IPI	molecular_function
GO:0005737	cytoplasm	IEA	cellular_component
GO:0031490	chromatin DNA binding	IEA	molecular_function
GO:0050994	regulation of lipid catabolic process	IEA	biological_process
GO:0019904	protein domain specific binding	IPI	molecular_function
GO:0006367	transcription initiation from RNA polymerase II pr	TAS	biological_process
GO:0044212	transcription regulatory region DNA binding	IDA	molecular_function
GO:0007611	learning or memory	IEA	biological_process
GO:0002153	steroid receptor RNA activator RNA binding	IEA	molecular_function
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0009887	organ morphogenesis	IEA	biological_process
GO:0003707	steroid hormone receptor activity	IEA	molecular_function
GO:0002155	regulation of thyroid hormone mediated signaling p	IEA	biological_process
GO:0030878	thyroid gland development	IEA	biological_process
GO:0043565	sequence-specific DNA binding	IEA	molecular_function
GO:0004887	thyroid hormone receptor activity	IEA	molecular_function
GO:0010831	positive regulation of myotube differentiation	IEA	biological_process
GO:0008050	female courtship behavior	IEA	biological_process
GO:0008016	regulation of heart contraction	IEA	biological_process
GO:0006355	regulation of transcription, DNA-dependent	IEA	biological_process
GO:0008270	zinc ion binding	IEA	molecular_function
GO:0009409	response to cold	IEA	biological_process
GO:0033032	regulation of myeloid cell apoptotic process	IEA	biological_process
GO:0017055	negative regulation of RNA polymerase II transcrip	IDA	biological_process
GO:0045892	negative regulation of transcription, DNA-dependen	IEA	biological_process
GO:0009755	hormone-mediated signaling pathway	IDA	biological_process
GO:0045925	positive regulation of female receptivity	IEA	biological_process
GO:0043401	steroid hormone mediated signaling pathway	IEA	biological_process
GO:0010467	gene expression	TAS	biological_process
GO:0045944	positive regulation of transcription from RNA poly	IEA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network