Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SHB_HUMAN
Description:Src homology 2 domain containing adaptor protein B [Source:HGNC Symbol;Acc:10838]
Location:chr9 p13.2
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S367SSPSPsRDRRRPhosphoSitePlus; HPRD
Y114MCRLDyCGGSGPhosphoSitePlus; HPRD
Y336RPADEyDQPWEPhosphoSitePlus; HPRD
S265AGKGEsAGYMEPhosphoSitePlus
T299IQLYDtPYEPEPhosphoSitePlus
Y27PPRPDyREQRRPhosphoSitePlus
T508PVAVRtL____PhosphoSitePlus
Y113AMCRLdYCGGSHPRD
Y272GYMEPyEAQRIPhosphoSitePlus
S310GQSVDsDSESTPhosphoSitePlus; HPRD
S317SESTVsPRLREPhosphoSitePlus; HPRD; phosphoELM
Y245VTIADdYSDPFHPRD
Y267KGESAgYMEPYHPRD
S164PHLYRsSSERRPhosphoSitePlus
Y335DRPADeYDQPWHPRD
S437YLVRNsQTSKHSH2PhosphoSitePlus
Y484PEVIHyYTTRKSH2PhosphoSitePlus
Y246TIADDySDPFDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S388PIKHGsPEFCGPhosphoSitePlus; HPRD; phosphoELM
S102NGPGSsLRKLRPhosphoSitePlus
S323PRLREsKLPQDPhosphoSitePlus
S314DSDSEsTVSPRHPRD; phosphoELM
S362NEKRQsSPSPSHPRD
Y96DFEDPyNGPGSPhosphoSitePlus
S190LIKVEsAAGGGPhosphoSitePlus
S166LYRSSsERRPAPhosphoSitePlus
Y301LYDTPyEPEGQPhosphoSitePlus
Y485EVIHYyTTRKLSH2PhosphoSitePlus
Y502HLSLLyPVAVRPhosphoSitePlus
S312SVDSDsESTVSPhosphoSitePlus; HPRD; phosphoELM
Y268GESAGyMEPYEPhosphoSitePlus; HPRD
S307EPEGQsVDSDSPhosphoSitePlus
S247IADDYsDPFDAPhosphoSitePlus
S165HLYRSsSERRPPhosphoSitePlus
Y297KGIQLyDTPYEPhosphoSitePlus

Dephosphorylation site
SHB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000366936A130VBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000366936G293SBIOMARTNeoplasms by Histologic Type21930507, 21930502

Differential expressed protein
SHB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SHB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SHB_HUMANFGFR1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
SHB_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006915apoptotic processIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0001525angiogenesisIEAbiological_process
GO:0005070SH3/SH2 adaptor activityTASmolecular_function


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