| UniProt/SwissProt ID: | SHB_HUMAN |
| Description: | Src homology 2 domain containing adaptor protein B [Source:HGNC Symbol;Acc:10838] |
| Location: | chr9 p13.2 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S367 | SSPSPsRDRRR | PhosphoSitePlus; HPRD | |
| Y114 | MCRLDyCGGSG | PhosphoSitePlus; HPRD | |
| Y336 | RPADEyDQPWE | PhosphoSitePlus; HPRD | |
| S265 | AGKGEsAGYME | PhosphoSitePlus | |
| T299 | IQLYDtPYEPE | PhosphoSitePlus | |
| Y27 | PPRPDyREQRR | PhosphoSitePlus | |
| T508 | PVAVRtL____ | PhosphoSitePlus | |
| Y113 | AMCRLdYCGGS | HPRD | |
| Y272 | GYMEPyEAQRI | PhosphoSitePlus | |
| S310 | GQSVDsDSEST | PhosphoSitePlus; HPRD | |
| S317 | SESTVsPRLRE | PhosphoSitePlus; HPRD; phosphoELM | |
| Y245 | VTIADdYSDPF | HPRD | |
| Y267 | KGESAgYMEPY | HPRD | |
| S164 | PHLYRsSSERR | PhosphoSitePlus | |
| Y335 | DRPADeYDQPW | HPRD | |
| S437 | YLVRNsQTSKH | SH2 | PhosphoSitePlus |
| Y484 | PEVIHyYTTRK | SH2 | PhosphoSitePlus |
| Y246 | TIADDySDPFD | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S388 | PIKHGsPEFCG | PhosphoSitePlus; HPRD; phosphoELM | |
| S102 | NGPGSsLRKLR | PhosphoSitePlus | |
| S323 | PRLREsKLPQD | PhosphoSitePlus | |
| S314 | DSDSEsTVSPR | HPRD; phosphoELM | |
| S362 | NEKRQsSPSPS | HPRD | |
| Y96 | DFEDPyNGPGS | PhosphoSitePlus | |
| S190 | LIKVEsAAGGG | PhosphoSitePlus | |
| S166 | LYRSSsERRPA | PhosphoSitePlus | |
| Y301 | LYDTPyEPEGQ | PhosphoSitePlus | |
| Y485 | EVIHYyTTRKL | SH2 | PhosphoSitePlus |
| Y502 | HLSLLyPVAVR | PhosphoSitePlus | |
| S312 | SVDSDsESTVS | PhosphoSitePlus; HPRD; phosphoELM | |
| Y268 | GESAGyMEPYE | PhosphoSitePlus; HPRD | |
| S307 | EPEGQsVDSDS | PhosphoSitePlus | |
| S247 | IADDYsDPFDA | PhosphoSitePlus | |
| S165 | HLYRSsSERRP | PhosphoSitePlus | |
| Y297 | KGIQLyDTPYE | PhosphoSitePlus | |
| Dephosphorylation site |
| SHB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000366936 | A130V | BIOMART | Neoplasms by Histologic Type | 21930507, 21930502 | ENSP00000366936 | G293S | BIOMART | Neoplasms by Histologic Type | 21930507, 21930502 |
| Differential expressed protein |
| SHB_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SHB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SHB_HUMAN | FGFR1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| SHB_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0030154 | cell differentiation | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0001525 | angiogenesis | IEA | biological_process |
| GO:0005070 | SH3/SH2 adaptor activity | TAS | molecular_function |