Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CSEN_HUMAN
Description:Kv channel interacting protein 3, calsenilin [Source:HGNC Symbol;Acc:15523]
Location:chr2 q11.1
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S14KASDGsLLGDLPhosphoSitePlus
T8PAKEVtKASDGPhosphoSitePlus
Y174WAFNLyDINKDEF_hand_5PhosphoSitePlus
S63QGSDSsDSELECK1_alphaphosphoELM
S63QGSDSsDSELECK1a(CK1 alphaRegPhos
S95KKELQsLYRGFPhosphoSitePlus
S63QGSDSsDSELEPhosphoSitePlus

Dephosphorylation site
CSEN_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000295225D139HCOSMICHead and Neck Cancer21798893
ENSP00000295225A170SSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000417499L43PTCGAOvarian Cancer21720365, 18772890
ENSP00000295225L69PCOSMICOvarian Cancer21720365
ENSP00000295225D179YSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000295225S62fs*130COSMICOvarian Cancer21720365

Differential expressed protein
CSEN_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CSEN_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KS6A2_HUMANCSEN_HUMANkinase -> substrateRobert H Newman (2013)
KC1A_HUMANCSEN_HUMANkinase -> substrateRobert H Newman (2013)
CSEN_HUMANFOS_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
CSEN_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003714transcription corepressor activityTASmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0005267potassium channel activityIEAmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0005244voltage-gated ion channel activityIEAmolecular_function
GO:0008022protein C-terminus bindingIEAmolecular_function
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0048306calcium-dependent protein bindingIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0006915apoptotic processIEAbiological_process
GO:0019233sensory perception of painIEAbiological_process
GO:0006886intracellular protein transportIEAbiological_process
GO:0048265response to painIEAbiological_process
GO:0015459potassium channel regulator activityIEAmolecular_function
GO:0005578proteinaceous extracellular matrixIEAcellular_component
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0005509calcium ion bindingIEAmolecular_function
GO:0007610behaviorIEAbiological_process
GO:0043523regulation of neuron apoptotic processIEAbiological_process


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