Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	LEF1_HUMAN
Description:	lymphoid enhancer-binding factor 1 [Source:HGNC Symbol;Acc:6551]
Location:	chr4 q25
Node attribute:	PPI(source); PPI(target); substrate; TF

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
Y160	TPLITySDEHF	CTNNB1_binding	PhosphoSitePlus
S166	SDEHFsPGSHP	NLK	HPRD; phosphoELM; RegPhos
Y102	PDGGLyNKGPS	CTNNB1_binding	PhosphoSitePlus
T195	APDIPtFYPLS	CTNNB1_binding	PhosphoSitePlus
T159	LTPLItYSDEH	CTNNB1_binding	PhosphoSitePlus
S161	PLITYsDEHFS	CTNNB1_binding	PhosphoSitePlus
Y348	EEQAKyYELAR	HMG_box	PhosphoSitePlus
S238	LSVDTsMSRFS		PhosphoSitePlus
S79	RQAQTsQEPYH	CTNNB1_binding	PhosphoSitePlus
T155	AVHPLtPLITY	NLK	HPRD; phosphoELM; RegPhos
T390	ESASGtGPRMT		PhosphoSitePlus
S61	SLVNEsEIIPA	CTNNB1_binding	PhosphoSitePlus
T155	AVHPLtPLITY	CTNNB1_binding	PhosphoSitePlus
Y197	DIPTFyPLSPG	CTNNB1_binding	PhosphoSitePlus
T208	GVGQItPPLGW	CTNNB1_binding	PhosphoSitePlus
Y349	EQAKYyELARK	HMG_box	PhosphoSitePlus
S240	VDTSMsRFSHH		PhosphoSitePlus
S42	IFAEIsHPEEE	CTNNB1_binding	PhosphoSitePlus
Y83	TSQEPyHDKAR	CTNNB1_binding	PhosphoSitePlus
S200	TFYPLsPGGVG	CTNNB1_binding	PhosphoSitePlus
S166	SDEHFsPGSHP	CTNNB1_binding	PhosphoSitePlus
S386	EKLQEsASGTG		PhosphoSitePlus
S132	SNGSLsPPIPR	CTNNB1_binding	PhosphoSitePlus
Y363	LHMQLyPGWSA	HMG_box	PhosphoSitePlus

Dephosphorylation site

LEF1_HUMAN do not have dephosphorylation site.

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000265165	G113R	HPI	Colorectal Cancer	16959974
ENSP00000265165	G113R	Sjoblom2006, COSMIC	Intestines Cancer	16959974
ENSP00000265165	S61P	OMIM	Skin Cancer	16565724
ENSP00000265165	E45K	OMIM	Skin Cancer	16565724

Differential expressed protein

LEF1_HUMAN is not differential expressed protein.

Hyperphosphorylation site

LEF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
NLK_HUMAN	LEF1_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
SOX17_HUMAN	LEF1_HUMAN	other	KEGG
CTBP1_HUMAN	LEF1_HUMAN	other	KEGG
LEF1_HUMAN	CCND1_HUMAN	other	KEGG
CTNB1_HUMAN	LEF1_HUMAN	other	KEGG
LEF1_HUMAN	BIRC5_HUMAN	other	KEGG
SMAD4_HUMAN	LEF1_HUMAN	other	KEGG
LEF1_HUMAN	MYC_HUMAN	other	KEGG
LEF1_HUMAN	PPARD_HUMAN	TF -> target gene	KEGG
LEF1_HUMAN	MYC_HUMAN	TF -> target gene	KEGG
LEF1_HUMAN	FOSL1_HUMAN	TF -> target gene	KEGG
LEF1_HUMAN	MMP7_HUMAN	TF -> target gene	KEGG
LEF1_HUMAN	CCND1_HUMAN	TF -> target gene	KEGG
LEF1_HUMAN	JUN_HUMAN	TF -> target gene	KEGG
LEF1_HUMAN	ADA_HUMAN	TF -> target gene	TRANSFAC
LEF1_HUMAN	TVA2_HUMAN	TF -> target gene	TRANSFAC
LEF1_HUMAN	MITF_HUMAN	TF -> target gene	TRANSFAC
LEF1_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
LEF1_HUMAN	U627C_HUMAN	TF -> target gene	TRANSFAC
LEF1_HUMAN	TYRP2_HUMAN	TF -> target gene	TRANSFAC

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa05215	Prostate cancer
hsa05221	Acute myeloid leukemia
hsa04916	Melanogenesis
hsa05210	Colorectal cancer
hsa05213	Endometrial cancer
hsa04520	Adherens junction
hsa05217	Basal cell carcinoma
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (A
hsa05216	Thyroid cancer
hsa05200	Pathways in cancer
hsa04310	Wnt signaling pathway

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0043565	sequence-specific DNA binding	IDA	molecular_function
GO:0003677	DNA binding	IEA	molecular_function
GO:0032714	negative regulation of interleukin-5 production	IDA	biological_process
GO:0021943	formation of radial glial scaffolds	IBA	biological_process
GO:0090068	positive regulation of cell cycle process	IDA	biological_process
GO:0021542	dentate gyrus development	IBA	biological_process
GO:0001228	RNA polymerase II transcription regulatory region	IMP	molecular_function
GO:0021766	hippocampus development	IEA	biological_process
GO:0071895	odontoblast differentiation	IBA	biological_process
GO:0008013	beta-catenin binding	IPI	molecular_function
GO:0006917	induction of apoptosis	IEA	biological_process
GO:0061153	trachea gland development	IEA	biological_process
GO:0042475	odontogenesis of dentin-containing tooth	IEA	biological_process
GO:0060325	face morphogenesis	IBA	biological_process
GO:0002040	sprouting angiogenesis	IBA	biological_process
GO:0060033	anatomical structure regression	IEA	biological_process
GO:0001569	patterning of blood vessels	IEA	biological_process
GO:0008301	DNA binding, bending	ISS	molecular_function
GO:0006366	transcription from RNA polymerase II promoter	IDA	biological_process
GO:0043392	negative regulation of DNA binding	IDA	biological_process
GO:0021943	formation of radial glial scaffolds	IEA	biological_process
GO:0060710	chorio-allantoic fusion	IEA	biological_process
GO:0043966	histone H3 acetylation	IMP	biological_process
GO:0021854	hypothalamus development	IBA	biological_process
GO:0048747	muscle fiber development	IBA	biological_process
GO:0016055	Wnt receptor signaling pathway	IEA	biological_process
GO:0048699	generation of neurons	IBA	biological_process
GO:0045063	T-helper 1 cell differentiation	ISS	biological_process
GO:0045892	negative regulation of transcription, DNA-dependen	IEA	biological_process
GO:0044212	transcription regulatory region DNA binding	IDA	molecular_function
GO:0003705	RNA polymerase II distal enhancer sequence-specifi	IEA	molecular_function
GO:0006357	regulation of transcription from RNA polymerase II	IEA	biological_process
GO:0071899	negative regulation of estrogen receptor binding	IDA	biological_process
GO:0010718	positive regulation of epithelial to mesenchymal t	IMP	biological_process
GO:0030307	positive regulation of cell growth	IMP	biological_process
GO:0060021	palate development	IEA	biological_process
GO:0061153	trachea gland development	IBA	biological_process
GO:0008284	positive regulation of cell proliferation	IDA	biological_process
GO:0043066	negative regulation of apoptotic process	IMP	biological_process
GO:0046632	alpha-beta T cell differentiation	IEA	biological_process
GO:0016055	Wnt receptor signaling pathway	IDA	biological_process
GO:0042100	B cell proliferation	IBA	biological_process
GO:0008134	transcription factor binding	IEA	molecular_function
GO:0060070	canonical Wnt receptor signaling pathway	IMP	biological_process
GO:0045944	positive regulation of transcription from RNA poly	IEA	biological_process
GO:0007420	brain development	IBA	biological_process
GO:0060710	chorio-allantoic fusion	IBA	biological_process
GO:0043923	positive regulation by host of viral transcription	IDA	biological_process
GO:0071864	positive regulation of cell proliferation in bone	IMP	biological_process
GO:0032993	protein-DNA complex	IDA	cellular_component
GO:0030335	positive regulation of cell migration	IMP	biological_process
GO:0070016	armadillo repeat domain binding	IPI	molecular_function
GO:0003677	DNA binding	ISS	molecular_function
GO:0021542	dentate gyrus development	IEA	biological_process
GO:0021861	forebrain radial glial cell differentiation	IBA	biological_process
GO:0005667	transcription factor complex	IEA	cellular_component
GO:0071345	cellular response to cytokine stimulus	IMP	biological_process
GO:0006917	induction of apoptosis	IBA	biological_process
GO:0046632	alpha-beta T cell differentiation	IBA	biological_process
GO:0070742	C2H2 zinc finger domain binding	IPI	molecular_function
GO:0003705	RNA polymerase II distal enhancer sequence-specifi	IBA	molecular_function
GO:0035326	enhancer binding	IDA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0021879	forebrain neuron differentiation	IBA	biological_process
GO:0003700	sequence-specific DNA binding transcription factor	IEA	molecular_function
GO:0016202	regulation of striated muscle tissue development	IBA	biological_process
GO:0048341	paraxial mesoderm formation	IBA	biological_process
GO:0003700	sequence-specific DNA binding transcription factor	IDA	molecular_function
GO:0005515	protein binding	IEA	molecular_function
GO:0001944	vasculature development	IEA	biological_process
GO:0030509	BMP signaling pathway	IEA	biological_process
GO:0060326	cell chemotaxis	IDA	biological_process
GO:0001755	neural crest cell migration	IBA	biological_process
GO:0001837	epithelial to mesenchymal transition	IEA	biological_process
GO:0010628	positive regulation of gene expression	IDA	biological_process
GO:0021873	forebrain neuroblast division	IEA	biological_process
GO:0030223	neutrophil differentiation	IMP	biological_process
GO:0042100	B cell proliferation	IEA	biological_process
GO:0000122	negative regulation of transcription from RNA poly	IEA	biological_process
GO:0060021	palate development	ISS	biological_process
GO:0090090	negative regulation of canonical Wnt receptor sign	IMP	biological_process
GO:0045892	negative regulation of transcription, DNA-dependen	IMP	biological_process
GO:0060561	apoptotic process involved in morphogenesis	IEA	biological_process
GO:0060325	face morphogenesis	IEA	biological_process
GO:0021873	forebrain neuroblast division	IBA	biological_process
GO:0045893	positive regulation of transcription, DNA-dependen	IDA	biological_process
GO:0021861	forebrain radial glial cell differentiation	IEA	biological_process
GO:0030509	BMP signaling pathway	IBA	biological_process
GO:0005737	cytoplasm	IEA	cellular_component
GO:0071866	negative regulation of apoptotic process in bone m	IMP	biological_process
GO:0005634	nucleus	IEA	cellular_component
GO:0043154	negative regulation of cysteine-type endopeptidase	IMP	biological_process
GO:0060561	apoptotic process involved in morphogenesis	IBA	biological_process
GO:0048069	eye pigmentation	IBA	biological_process
GO:0030326	embryonic limb morphogenesis	IBA	biological_process
GO:0002040	sprouting angiogenesis	IEA	biological_process
GO:0003682	chromatin binding	IEA	molecular_function
GO:0032696	negative regulation of interleukin-13 production	IDA	biological_process
GO:0045063	T-helper 1 cell differentiation	IEA	biological_process
GO:0005667	transcription factor complex	IDA	cellular_component
GO:0044212	transcription regulatory region DNA binding	IEA	molecular_function
GO:0022409	positive regulation of cell-cell adhesion	IDA	biological_process
GO:0030879	mammary gland development	IBA	biological_process
GO:0033153	T cell receptor V(D)J recombination	IEA	biological_process
GO:0045843	negative regulation of striated muscle tissue deve	IEA	biological_process
GO:0043967	histone H4 acetylation	IMP	biological_process
GO:0030284	estrogen receptor activity	IDA	molecular_function
GO:0001756	somitogenesis	IBA	biological_process
GO:0022008	neurogenesis	IBA	biological_process
GO:0001756	somitogenesis	IEA	biological_process
GO:0045944	positive regulation of transcription from RNA poly	IDA	biological_process
GO:0050909	sensory perception of taste	IEA	biological_process
GO:0001649	osteoblast differentiation	IEP	biological_process
GO:0045893	positive regulation of transcription, DNA-dependen	IEA	biological_process
GO:0005634	nucleus	IDA	cellular_component
GO:0001569	patterning of blood vessels	IBA	biological_process
GO:0030111	regulation of Wnt receptor signaling pathway	IEA	biological_process
GO:0030879	mammary gland development	IEA	biological_process
GO:0043027	cysteine-type endopeptidase inhibitor activity inv	IMP	molecular_function
GO:0003682	chromatin binding	IBA	molecular_function
GO:0022408	negative regulation of cell-cell adhesion	IDA	biological_process
GO:0030854	positive regulation of granulocyte differentiation	IDA	biological_process
GO:0048341	paraxial mesoderm formation	IEA	biological_process
GO:0030326	embryonic limb morphogenesis	IEA	biological_process
GO:0071353	cellular response to interleukin-4	IDA	biological_process
GO:0005737	cytoplasm	IDA	cellular_component
GO:0042393	histone binding	IPI	molecular_function
GO:0022407	regulation of cell-cell adhesion	IEA	biological_process
GO:0030331	estrogen receptor binding	IDA	molecular_function
GO:0045295	gamma-catenin binding	IPI	molecular_function
GO:0032713	negative regulation of interleukin-4 production	IDA	biological_process
GO:0001837	epithelial to mesenchymal transition	ISS	biological_process
GO:0008301	DNA binding, bending	IEA	molecular_function
GO:0000977	RNA polymerase II regulatory region sequence-speci	IDA	molecular_function
GO:0043586	tongue development	IEA	biological_process
GO:0048468	cell development	IEA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network