| UniProt/SwissProt ID: | ANS1A_HUMAN |
| Description: | ankyrin repeat and sterile alpha motif domain containing 1A [Source:HGNC Symbol;Acc:20961] |
| Location: | chr6 p21.31 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S480 | DHRRSsSSRSQ | PhosphoSitePlus | |
| S692 | ERQKIsGLRTL | PhosphoSitePlus | |
| T696 | ISGLRtLEQSV | PhosphoSitePlus | |
| S677 | EKIMSsIGEGI | PhosphoSitePlus; HPRD | |
| S331 | ISSMDsISQKS | PhosphoSitePlus | |
| T958 | KDLRGtESTQD | HPRD | |
| S336 | SISQKsQGDVE | PhosphoSitePlus | |
| S647 | GSRSEsLSNCS | PhosphoSitePlus; HPRD; phosphoELM | |
| Y454 | EEDEHpYELLL | HPRD | |
| S481 | HRRSSsSRSQD | PhosphoSitePlus | |
| Y568 | SKRVGyLTGLP | PhosphoSitePlus | |
| S479 | KDHRRsSSSRS | PhosphoSitePlus | |
| S628 | LSKSDsDLLTC | PhosphoSitePlus; HPRD | |
| Y834 | LADRPyEEPPQ | PhosphoSitePlus; HPRD | |
| S482 | RRSSSsRSQDS | PhosphoSitePlus | |
| S887 | RRRHDsLHDPA | PhosphoSitePlus | |
| Y427 | HIDKKyFPLTA | PhosphoSitePlus | |
| S666 | SPSFAsEWDEI | PhosphoSitePlus | |
| S333 | SMDSIsQKSQG | PhosphoSitePlus | |
| T460 | YELLLtAETKK | PhosphoSitePlus; HPRD | |
| S620 | AELKLsRSLSK | PhosphoSitePlus | |
| Y455 | EDEHPyELLLT | PhosphoSitePlus; HPRD | |
| S652 | SLSNCsIGKKR | PhosphoSitePlus; HPRD | |
| S845 | KPPRFsQLRCQ | PhosphoSitePlus | |
| S445 | PRIHGsAAREE | PhosphoSitePlus | |
| S663 | LEKSPsFASEW | PhosphoSitePlus; HPRD; phosphoELM | |
| S949 | ANYLGsMLIKD | HPRD | |
| Y946 | GYEANyLGSML | HPRD | |
| S854 | CQDLLsQTSSP | PhosphoSitePlus | |
| T463 | LLTAEtKKVVL | HPRD | |
| S661 | KRLEKsPSFAS | PhosphoSitePlus; HPRD | |
| S645 | TMGSRsESLSN | PhosphoSitePlus | |
| S828 | KRIIAsLADRP | SAM_1 | PhosphoSitePlus |
| S622 | LKLSRsLSKSD | PhosphoSitePlus; HPRD | |
| S626 | RSLSKsDSDLL | HPRD | |
| Y922 | SLAAPyAPVQS | PhosphoSitePlus | |
| T610 | SRAPPtSKPKA | PhosphoSitePlus | |
| T318 | KEVDKtPPPQP | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| ANS1A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000353518 | S66N | COSMIC | Skin Cancer | 21984974 | ENSP00000353518 | Q264H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000353518 | R606* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000353518 | Q264H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000353518 | R606* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000353518 | L168I | COSMIC | Head and Neck Cancer | 21798897 |
| Differential expressed protein |
| ANS1A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ANS1A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK21_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK4_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TGFR2_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| EPHA3_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PI3R4_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PK3C3_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK3_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BMPR2_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCZ_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GSK3A_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGFR1_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| WNK1_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ANS1A_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006929 | substrate-dependent cell migration | IEA | biological_process |
| GO:0048013 | ephrin receptor signaling pathway | ISS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0016322 | neuron remodeling | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016322 | neuron remodeling | ISS | biological_process |
| GO:0006929 | substrate-dependent cell migration | ISS | biological_process |
| GO:0046875 | ephrin receptor binding | IEA | molecular_function |
| GO:0048013 | ephrin receptor signaling pathway | IEA | biological_process |
| GO:0043005 | neuron projection | ISS | cellular_component |
| GO:0043005 | neuron projection | IEA | cellular_component |