Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IBP1_HUMAN
Description:insulin-like growth factor binding protein 1 [Source:HGNC Symbol;Acc:5469]
Location:chr7 p12.3
Node attribute:TF; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S144HLMAPsEEDHSPhosphoSitePlus; HPRD; phosphoELM
S194KAQETsGEEISHPRD; phosphoELM
S108ACVQEsDASAPHPRD
S126PESPEsTEITEPhosphoSitePlus; HPRD; phosphoELM
S120AAEAGsPESPEPhosphoSitePlus
S194KAQETsGEEISThyroglobulin_1PhosphoSitePlus
Y181CRIELyRVVESThyroglobulin_1PhosphoSitePlus
S123AGSPEsPESTEPhosphoSitePlus

Dephosphorylation site
IBP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000275525W152SCOSMICLung Cancer20668451

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000275525Lung CancerNormal vs. CancertissueDown15626334
ENSP00000275525Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.4215169874

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S144NFHLMAPsEEDHSILFetal growth restriction19193607PhosphoSitePlus
S126GSPESPEsTEITEEEFetal growth restriction20143870PhosphoSitePlus
S194Thyroglobulin_1LAKAQETsGEEISKFFetal growth restriction20143870PhosphoSitePlus
S123AEAGSPEsPESTEITFetal growth restriction20143870PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
PRGR_HUMANIBP1_HUMANTF -> target geneTRANSFAC
FOXO4_HUMANIBP1_HUMANTF -> target geneTRANSFAC
FOXO1_HUMANIBP1_HUMANTF -> target geneTRANSFAC
FOXA1_HUMANIBP1_HUMANTF -> target geneTRANSFAC
IBP1_HUMANIFNB_HUMANTF -> target geneTRANSFAC
HMGA1_HUMANIBP1_HUMANTF -> target geneTRANSFAC
CREB1_HUMANIBP1_HUMANTF -> target geneTRANSFAC
FOXA2_HUMANIBP1_HUMANTF -> target geneTRANSFAC
GCR_HUMANIBP1_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANIBP1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
IBP1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030968endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0030307positive regulation of cell growthIEAbiological_process
GO:0008286insulin receptor signaling pathwayIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0001558regulation of cell growthIEAbiological_process
GO:0006987activation of signaling protein activity involved TASbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0005520insulin-like growth factor bindingIEAmolecular_function
GO:0005615extracellular spaceIEAcellular_component
GO:0042246tissue regenerationIEAbiological_process


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