Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MTOR_HUMAN
Description:mechanistic target of rapamycin (serine/threonine kinase) [Source:HGNC Symbol;Acc:3942]
Location:chr1 p36.22
Node attribute:PPI(source); substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T2446RSRTRtDSYSAPKB_groupphosphoELM
S1297LKDSSsPSLRSPhosphoSitePlus
S2448RTRTDsYSAGQp70S6KphosphoELM
S1171SPELRsTAMDTPhosphoSitePlus
S2448RTRTDsYSAGQRPS6KB1HPRD
Y1232EDPLIyQHRMLPhosphoSitePlus
Y2449TRTDSySAGQSPhosphoSitePlus
S2159QSIAPsLQVITPhosphoSitePlus
S1893FFRSIsLSRGNFATPhosphoSitePlus
T1172PELRStAMDTLPhosphoSitePlus
T102EGGNAtRIGRFHEAT_2PhosphoSitePlus
T1262KLHVStINLQKHPRD; phosphoELM
S92ILAIAsLIGVEHEAT_2PhosphoSitePlus
S2478TTVPEsIHSFIPhosphoSitePlus; HPRD; phosphoELM
S1847ASTEGsNSESEHPRD
Y110GRFANyLRNLLHEAT_2PhosphoSitePlus
S2448RTRTDsYSAGQPhosphoSitePlus; HPRD; phosphoELM
S2448RTRTDsYSAGQPKB_groupphosphoELM
S1166RTLDQsPELRSPhosphoSitePlus; HPRD
T1876EDLSKtLLMYTFATPhosphoSitePlus
S567AHQLAsPGLTTPhosphoSitePlus; HPRD
T314KPRHItPFTSFPhosphoSitePlus
T2446RSRTRtDSYSAp70S6KphosphoELM
T2444NKRSRtRTDSYPhosphoSitePlus; HPRD
S2454YSAGQsVEILDPhosphoSitePlus; HPRD
S2442KGNKRsRTRTDPhosphoSitePlus
S719TVGRLsSMNPAHEAT_2PhosphoSitePlus
T308LMGFGtKPRHIPhosphoSitePlus
T2446RSRTRtDSYSAPhosphoSitePlus
T1870LQKKVtEDLSKFATPhosphoSitePlus
S1299DSSSPsLRSCWPhosphoSitePlus
S2448RTRTDsYSAGQAKT1HPRD
S2448RTRTDsYSAGQRPS6KA1HPRD
S1131EAPLPsRKAALPhosphoSitePlus
T2473HKKTGtTVPESPhosphoSitePlus
S1288WLRRLsLELLKPhosphoSitePlus
T2474KKTGTtVPESIPhosphoSitePlus; HPRD; phosphoELM
S2481PESIHsFIGDGmTORphosphoELM
Y1880KTLLMyTVPAVFATPhosphoSitePlus
S1849TEGSNsESEAEHPRD
T2446RSRTRtDSYSAPRKAA1HPRD
T1502CCEKWtLVNDETPR_11PhosphoSitePlus
T2471PAHKKtGTTVPPhosphoSitePlus
S2481PESIHsFIGDGMTORHPRD
S1874VTEDLsKTLLMFATPhosphoSitePlus
T1162HPIVRtLDQSPPhosphoSitePlus; HPRD; phosphoELM
T2446RSRTRtDSYSAAKT1HPRD
S1821KLRHAsGANITFATPhosphoSitePlus
T2164SLQVItSKQRPPhosphoSitePlus
S2481PESIHsFIGDGPhosphoSitePlus; phosphoELM
T2446RSRTRtDSYSARPS6KA1HPRD
S1261KKLHVsTINLQPhosphoSitePlus; HPRD
S2450RTDSYsAGQSVPhosphoSitePlus

Dephosphorylation site
MTOR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000354558Q1866*Greenman2007Intestines Cancer17344846, 18428421
ENSP00000354558S2215YHPIColorectal Cancer17344846 20190810
ENSP00000354558P2476LGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000354558P2476LGreenman2007, HPINeoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000354558S2215YGreenman2007Intestines Cancer17344846, 18428421
ENSP00000354558A8SHPINon-small cell lung carcinoma17344846
ENSP00000354558A8SGreenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000354558M135TGreenman2007Skin Cancer17344846, 18428421
ENSP00000354558M2011VGreenman2007, HPIOvarian Cancer17344846, 18428421

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000354558Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S2448RSRTRTDsYSAGQSVovarian cancer15208673PhosphoSitePlus
S2448RSRTRTDsYSAGQSVadrenocortical carcinoma20484036PhosphoSitePlus
S2481TVPESIHsFIGDGLVbreast cancer19956839PhosphoSitePlus
S2448RSRTRTDsYSAGQSVovarian epithelial carcinoma21276607PhosphoSitePlus
S2448RSRTRTDsYSAGQSVpancreatic cancer21474066PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KS6B1_HUMANMTOR_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MTOR_HUMANMTOR_HUMANkinase -> substrateHPRD; RegPhos
MTOR_HUMANKS6B2_HUMANkinase -> substrateRegPhos
AKT3_HUMANMTOR_HUMANkinase -> substrateKEGG
MTOR_HUMAN4EBP1_HUMANkinase -> substrateRegPhos; NetPath
ZAGL2_HUMANMTOR_HUMANkinase -> substrateRegPhos
MTOR_HUMANKS6B1_HUMANkinase -> substrateRegPhos
AAPK1_HUMANMTOR_HUMANkinase -> substrateKEGG; HPRD
AKT1_HUMANMTOR_HUMANkinase -> substrateRegPhos
MTOR_HUMANULK3_HUMANkinase -> substrateKEGG
MTOR_HUMANHIF1A_HUMANkinase -> substrateKEGG
KS6A1_HUMANMTOR_HUMANkinase -> substrateHPRD
MTOR_HUMANAKT3_HUMANkinase -> substrateKEGG
AKTS1_HUMANMTOR_HUMANkinase -> substrateKEGG
RHEB_HUMANMTOR_HUMANotherKEGG
MTOR_HUMANIRS1_HUMANotherKEGG
PI3R5_HUMANMTOR_HUMANotherKEGG
TRAF2_HUMANMTOR_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04930Type II diabetes mellitus
hsa04920Adipocytokine signaling pathway
hsa04012ErbB signaling pathway
hsa05215Prostate cancer
hsa04910Insulin signaling pathway
hsa04150mTOR signaling pathway
hsa05221Acute myeloid leukemia
hsa05200Pathways in cancer
hsa05214Glioma

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIEAbiological_process
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0006468protein phosphorylationIDAbiological_process
GO:0005979regulation of glycogen biosynthetic processIEAbiological_process
GO:0032095regulation of response to foodIEAbiological_process
GO:0031998regulation of fatty acid beta-oxidationIEAbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0030163protein catabolic processTASbiological_process
GO:0031931TORC1 complexIEAcellular_component
GO:0010507negative regulation of autophagyISSbiological_process
GO:0045792negative regulation of cell sizeIEAbiological_process
GO:0000139Golgi membraneIEAcellular_component
GO:0070438mTOR-FKBP12-rapamycin complexIEAcellular_component
GO:0016242negative regulation of macroautophagyIEAbiological_process
GO:0051534negative regulation of NFAT protein import into nuIEAbiological_process
GO:0071456cellular response to hypoxiaIEAbiological_process
GO:0016605PML bodyIEAcellular_component
GO:0043610regulation of carbohydrate utilizationIEAbiological_process
GO:0032868response to insulin stimulusIEAbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0010628positive regulation of gene expressionIMPbiological_process
GO:0051496positive regulation of stress fiber assemblyIEAbiological_process
GO:0006109regulation of carbohydrate metabolic processIEAbiological_process
GO:0016310phosphorylationIDAbiological_process
GO:0006950response to stressIMPbiological_process
GO:0045727positive regulation of translationIEAbiological_process
GO:0001934positive regulation of protein phosphorylationIDAbiological_process
GO:0031529ruffle organizationIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0045945positive regulation of transcription from RNA polyIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0051897positive regulation of protein kinase B signaling IEAbiological_process
GO:0001032RNA polymerase III type 3 promoter DNA bindingIDAmolecular_function
GO:0016049cell growthTASbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0051219phosphoprotein bindingIPImolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007165signal transductionNASbiological_process
GO:0032314regulation of Rac GTPase activityIEAbiological_process
GO:0005942phosphatidylinositol 3-kinase complexNAScellular_component
GO:0018107peptidyl-threonine phosphorylationIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007281germ cell developmentIEAbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0016301kinase activityTASmolecular_function
GO:0018105peptidyl-serine phosphorylationIEAbiological_process
GO:0007584response to nutrientNASbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0030838positive regulation of actin filament polymerizatiIEAbiological_process
GO:0010831positive regulation of myotube differentiationIEAbiological_process
GO:0016020membraneIDAcellular_component
GO:0010507negative regulation of autophagyIEAbiological_process
GO:0031932TORC2 complexIDAcellular_component
GO:0005764lysosomeIDAcellular_component
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0046889positive regulation of lipid biosynthetic processIMPbiological_process
GO:0005741mitochondrial outer membraneIEAcellular_component
GO:0001156TFIIIC-class transcription factor bindingIDAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0045859regulation of protein kinase activityIEAbiological_process
GO:0010592positive regulation of lamellipodium assemblyIEAbiological_process
GO:0012505endomembrane systemIDAcellular_component
GO:0032956regulation of actin cytoskeleton organizationIMPbiological_process
GO:0005488bindingIEAmolecular_function
GO:0031669cellular response to nutrient levelsIEAbiological_process
GO:0001030RNA polymerase III type 1 promoter DNA bindingIDAmolecular_function
GO:0008144drug bindingIEAmolecular_function
GO:0001031RNA polymerase III type 2 promoter DNA bindingIDAmolecular_function
GO:0001938positive regulation of endothelial cell proliferatIEAbiological_process
GO:0031929TOR signaling cascadeIMPbiological_process
GO:0030030cell projection organizationIEAbiological_process
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0040007growthNASbiological_process
GO:0043022ribosome bindingIEAmolecular_function
GO:0043200response to amino acid stimulusIEAbiological_process