Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EGFR_HUMAN
Description:epidermal growth factor receptor [Source:HGNC Symbol;Acc:3236]
Location:chr7 p11.2
Node attribute:PPI(source); PPI(target); substrate; kinase; receptor; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1197AENAEyLRVAPEGFRHPRD; phosphoELM; RegPhos; SysPTM
Y998TDSNFyRALMDSRCHPRD; SysPTM
S768AYVMAsVDNPHCaM-KII_alphaphosphoELM
T290YSFGAtCVKKCHPRD
T940QPPICtIDVYMPkinase_TyrPhosphoSitePlus
S695EPLTPsGEAPNPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y113RGNMYyENSYARecep_L_domainPhosphoSitePlus
Y1016VDADEyLIPQQPhosphoSitePlus; HPRD; phosphoELM
S1028FFSSPsTSRTPHPRD; phosphoELM; RegPhos
S1064PIKEDsFLQRYCaMK2aRegPhos; SysPTM
S1120LNPAPsRDPHYCaMK2aRegPhos
Y1172LDNPDyQQDFFPhosphoSitePlus; phosphoELM; SysPTM
Y1172LDNPDyQQDFFautocatalysisRegPhos; SysPTM
T1041SSLSAtSNNSTPhosphoSitePlus; HPRD; phosphoELM
T693LVEPLtPSGEAErk2(MAPK1RegPhos; SysPTM
S768AYVMAsVDNPHphosphoELM
T1046TSNNStVACIDPhosphoSitePlus
S1166GSHQIsLDNPDCaM-KII_alphaphosphoELM; SysPTM
S1070FLQRYsSDPTGCAMK2AHPRD
Y1172LDNPDyQQDFFEGFRHPRD; phosphoELM; RegPhos; SysPTM
Y1138VGNPEyLNTVQPhosphoSitePlus; HPRD; RegPhos; SysPTM
S1064PIKEDsFLQRYCAMK2AHPRD; SysPTM
Y1016VDADEyLIPQQSRCphosphoELM
Y869AEEKEyHAEGGSrcRegPhos; SysPTM
S1162WAQKGsHQISLPhosphoSitePlus
S768AYVMAsVDNPHCAMK2AHPRD
S1070FLQRYsSDPTGCAMK2GHPRD
Y1016VDADEyLIPQQEGFRHPRD; RegPhos
S1081ALTEDsIDDTFCaM-KII_alphaphosphoELM; SysPTM
T678IVRKRtLRRLLPKCa(PKC alphaRegPhos
Y1069SFLQRySSDPTEGFRHPRD; RegPhos; SysPTM
Y869AEEKEyHAEGGphosphoELM; SysPTM
S720IKVLGsGAFGTHPRD
S995PSPTDsNFYRAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1166GSHQIsLDNPDCaMK2aRegPhos; SysPTM
S991RMHLPsPTDSNPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y1092LPVPEyINQSVEGFRHPRD; phosphoELM; RegPhos; SysPTM
S768AYVMAsVDNPHCaMK2aRegPhos
S1081ALTEDsIDDTFCaMK2aRegPhos; SysPTM
T993HLPSPtDSNFYPhosphoSitePlus; HPRD; phosphoELM
Y764ILDEAyVMASVPkinase_TyrPhosphoSitePlus
T678IVRKRtLRRLLPKC_alphaphosphoELM
Y869AEEKEyHAEGGPkinase_TyrPhosphoSitePlus; SysPTM
S1081ALTEDsIDDTFCAMK2AHPRD; SysPTM
Y1110VQNPVyHNQPLautocatalysisRegPhos; SysPTM
S1057RNGLQsCPIKEPhosphoSitePlus
T1131QDPHStAVGNPPhosphoSitePlus
T1145NTVQPtCVNSTPhosphoSitePlus
Y1125SRDPHyQDPHSPhosphoSitePlus
Y1110VQNPVyHNQPLPhosphoSitePlus; phosphoELM; SysPTM
S1081ALTEDsIDDTFPhosphoSitePlus; phosphoELM; SysPTM
S1071LQRYSsDPTGACAMK2GHPRD
S1071LQRYSsDPTGACAMK2AHPRD
T725SGAFGtVYKGLHPRD; SysPTM
S1026QGFFSsPSTSRCDK1phosphoELM; SysPTM
Y727AFGTVyKGLWIHPRD
Y869AEEKEyHAEGGSRCHPRD; phosphoELM; RegPhos; SysPTM
S1030SSPSTsRTPLLPhosphoSitePlus
S1120LNPAPsRDPHYCAMK2AHPRD
S1070FLQRYsSDPTGCaM-KII_alphaphosphoELM
S1190GIFKGsTAENAPhosphoSitePlus; phosphoELM; RegPhos
S1025QQGFFsSPSTSPhosphoSitePlus; HPRD; phosphoELM
Y944CTIDVyMIMVKSRCHPRD; phosphoELM; RegPhos
Y1069SFLQRySSDPTJAK2HPRD; RegPhos; SysPTM
Y944CTIDVyMIMVKPkinase_TyrPhosphoSitePlus
T678IVRKRtLRRLLPKC_groupphosphoELM; RegPhos
Y1092LPVPEyINQSVPhosphoSitePlus; phosphoELM; SysPTM
T1078PTGALtEDSIDHPRD; phosphoELM
S1045ATSNNsTVACIPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y1069SFLQRySSDPTPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T678IVRKRtLRRLLPKCdRegPhos
S1070FLQRYsSDPTGPhosphoSitePlus; phosphoELM; RegPhos
T725SGAFGtVYKGLPkinase_TyrPhosphoSitePlus; SysPTM
T693LVEPLtPSGEAMAPK3phosphoELM; SysPTM
T693LVEPLtPSGEAMAPK1phosphoELM; SysPTM
T678IVRKRtLRRLLPRKCDHPRD
T648IPSIAtGMVGATMPhosphoSitePlus
S511CHALCsPEGCWFurin-likePhosphoSitePlus
Y1125SRDPHyQDPHSSRCHPRD; phosphoELM; RegPhos
S1071LQRYSsDPTGACaM-KII_alphaphosphoELM
S720IKVLGsGAFGTPkinase_TyrPhosphoSitePlus
Y117YYENSyALAVLRecep_L_domainPhosphoSitePlus
Y727AFGTVyKGLWIPkinase_TyrPhosphoSitePlus
Y585IQCAHyIDGPHFurin-likePhosphoSitePlus
S1036RTPLLsSLSATHPRD
S1037TPLLSsLSATSPhosphoSitePlus; HPRD; phosphoELM
Y112IRGNMyYENSYRecep_L_domainPhosphoSitePlus
T693LVEPLtPSGEAPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y1125SRDPHyQDPHSSrcRegPhos
T693LVEPLtPSGEAErk1(MAPK3RegPhos; SysPTM
Y944CTIDVyMIMVKSrcRegPhos
Y1092LPVPEyINQSVautocatalysisRegPhos; SysPTM
S151GAVRFsNNPALRecep_L_domainPhosphoSitePlus
S1166GSHQIsLDNPDCAMK2AHPRD; SysPTM
Y1092LPVPEyINQSVSRCHPRD; RegPhos; SysPTM
S1026QGFFSsPSTSRPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T1150TCVNStFDSPAPhosphoSitePlus
S1130YQDPHsTAVGNPhosphoSitePlus
Y915FGSKPyDGIPASRCHPRD; phosphoELM; RegPhos
T1191IFKGStAENAEPhosphoSitePlus
S1064PIKEDsFLQRYPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S752LREATsPKANKPkinase_TyrPhosphoSitePlus
Y1197AENAEyLRVAPautocatalysisRegPhos; SysPTM
Y915FGSKPyDGIPASrcRegPhos
Y1197AENAEyLRVAPPhosphoSitePlus; phosphoELM; SysPTM
Y1110VQNPVyHNQPLEGFRHPRD; phosphoELM; RegPhos; SysPTM
Y801GCLLDyVREHKPkinase_TyrPhosphoSitePlus
Y998TDSNFyRALMDPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S1096EYINQsVPKRPPhosphoSitePlus
S1153NSTFDsPAHWAPhosphoSitePlus
S1070FLQRYsSDPTGCaMK2aRegPhos
T1085DSIDDtFLPVPPhosphoSitePlus; HPRD; phosphoELM
S1071LQRYSsDPTGACaMK2gRegPhos
S1071LQRYSsDPTGACaMK2aRegPhos
S1070FLQRYsSDPTGCaMK2gRegPhos
S229RGKSPsDCCHNFurin-likePhosphoSitePlus
S1071LQRYSsDPTGAPhosphoSitePlus; phosphoELM; RegPhos
S1026QGFFSsPSTSRCDC2(CDK1RegPhos; SysPTM
T678IVRKRtLRRLLPhosphoSitePlus; phosphoELM
Y978RDPQRyLVIQGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1166GSHQIsLDNPDPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S768AYVMAsVDNPHPkinase_TyrPhosphoSitePlus
S645GPKIPsIATGMPhosphoSitePlus
S1039LLSSLsATSNNPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y1069SFLQRySSDPTERBB2HPRD; SysPTM
S1104KRPAGsVQNPVPhosphoSitePlus; phosphoELM; RegPhos
T1141PEYLNtVQPTCPhosphoSitePlus
Y827AKGMNyLEDRRPkinase_TyrPhosphoSitePlus
T1074YSSDPtGALTEPhosphoSitePlus
S1042SLSATsNNSTVPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T693HLHAWpSASVIHPRD; SysPTM
Y891ILHRIyTHQSDHPRD
S1120LNPAPsRDPHYPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1016DVVDADEyLIPQQGFPTPN11HPRD
Y1197STAENAEyLRVAPQSPTPN6HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000275493D256ATCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000275493R680GTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000275493P772RTCGAOvarian Cancer21720365, 18772890
ENSP00000345973S380fs*16COSMICOvarian Cancer21720365
ENSP00000275493G719SOMIMNon-small cell lung carcinoma15118125
ENSP00000275493Q1164RTCGAOvarian Cancer21720365, 18772890
ENSP00000275493C636YBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000275493S768IDing2008Central Nervous System Neoplasms15604253, 15623594, 15741570, 15998907, 16043828, 16410744, 16863509, 17285735, 17626639, 18176089, 18428421, 18948947
ENSP00000275493G719SBIOMARTLung Cancer21930507, 21930502
ENSP00000275493C219GBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000275493S768IDing2008Head and Neck Cancer15604253, 15623594, 15741570, 15998907, 16043828, 16410744, 16863509, 17285735, 17626639, 18176089, 18428421, 18948947
ENSP00000275493L833VDing2008, BIOMARTLung Cancer15623594, 16533793, 17409930, 17473653, 18428421, 18948947, 21930507, 21930502
ENSP00000275493V651MDing2008, BIOMARTLung Cancer18772890, 18948947, 21930507, 21930502, 21720365
ENSP00000275493G719SDing2008Lung Cancer15118125, 15604253, 15625347, 15741570, 15998907, 16105816, 16199108, 16533793, 17192902, 17285735, 17473653, 17904685, 18176089, 18334834, 18428421, 18948947
ENSP00000275493R252CTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000345973S653CCOSMICCentral Nervous System Neoplasms
ENSP00000275493R324LBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000275493L858ROMIMNon-small cell lung carcinoma15118073 15118125 15329413 15901872
ENSP00000275493T263PTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000275493L861QDing2008Central Nervous System Neoplasms15118073, 15623594, 15738541, 15958609, 16105816, 16199108, 16533793, 16870303, 17177598, 17233841, 17285735, 17561305, 18176089, 18258923, 18428421, 18785203, 18948947
ENSP00000275493R108KTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000275493R451FDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000275493L858RBIOMART, OMIMLung Cancer21930507, 21930502, 15118073 15118125 15329413 15901872
ENSP00000275493C620YTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000345973M178ICOSMICHead and Neck Cancer21798893
ENSP00000275493R222CBIOMART, TCGANeoplasms by Histologic Type21930507, 21930502, 21720365, 18772890
ENSP00000345973H559YCOSMICLung Cancer20668451
ENSP00000275493A597TDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000275493V651MDing2008, TCGANeoplasms by Histologic Type18772890, 18948947, 21930507, 21930502, 21720365
ENSP00000275493T790MOMIMNon-small cell lung carcinoma15728811 11423618 15901872 16258541 20033049
ENSP00000275493P136TDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000275493L861RDing2008Lung Cancer15741570, 16863509, 17580276, 18428421, 18948947
ENSP00000275493L858RDing2008Other Cancer(thymus cancer)15118073, 15118125, 15329413, 15492241, 15604253, 15623594, 15681531, 15710947, 15738541, 15741570, 15780185, 15788655, 15851406, 15870435, 15901872, 15958609, 15998907, 16014883, 16014893, 16043828, 16052218, 16105816, 16140420, 16199108, 16204011, 16382114, 16407879, 16467080, 16533793, 16613660, 16619582, 16778591, 16863509, 16870303, 17060940, 17085664, 17186532, 17192868, 17192902, 17233841, 17238183, 17285735, 17321325, 17332333, 17368623, 17409930, 17473653, 17487277, 17505415, 17537621, 17561305, 17565015, 17573511, 17580276, 17626639, 17784875, 17785547, 17904685, 17917328, 17941001, 17945377, 17973572, 18061305, 18089646, 18176089, 18186961, 18202784, 18208799, 18258923, 18261621, 18271876, 18334834, 18372921, 18403609, 18428421, 18448188, 18676744, 18948947, 18985444, 19002495, 19010870, 19020901, 19063875, 19096301
ENSP00000275493V292LTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000275493E602QBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000275493A597PTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000275493A839VTCGAOvarian Cancer21720365, 18772890
ENSP00000275493G598VBIOMART, TCGANeoplasms by Histologic Type21930507, 21930502, 21720365, 18772890
ENSP00000275493E709QTCGAOvarian Cancer21720365, 18772890
ENSP00000275493A289VBIOMART, TCGANeoplasms by Histologic Type21930507, 21930502, 21720365, 18772890
ENSP00000345973I475VCOSMICHead and Neck Cancer21798893
ENSP00000275493S768IDing2008, BIOMARTLung Cancer15604253, 15623594, 15741570, 15998907, 16043828, 16410744, 16863509, 17285735, 17626639, 18176089, 18428421, 18948947, 21930507, 21930502
ENSP00000275493Q105HTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000275493L62RTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000275493G719SDing2008Intestines Cancer15118125, 15604253, 15625347, 15741570, 15998907, 16105816, 16199108, 16533793, 17192902, 17285735, 17473653, 17904685, 18176089, 18334834, 18428421, 18948947
ENSP00000275493F968LBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000275493P596LTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000345973E204KCOSMICLung Cancer20668451
ENSP00000275493L861QDing2008, BIOMARTLung Cancer15118073, 15623594, 15738541, 15958609, 16105816, 16199108, 16533793, 16870303, 17177598, 17233841, 17285735, 17561305, 18176089, 18258923, 18428421, 18785203, 18948947, 21930507, 21930502
ENSP00000275493D1168NBIOMARTchronic lymphocytic leukemia21930507, 21930502
ENSP00000275493L858RDing2008Lung Cancer15118073, 15118125, 15329413, 15492241, 15604253, 15623594, 15681531, 15710947, 15738541, 15741570, 15780185, 15788655, 15851406, 15870435, 15901872, 15958609, 15998907, 16014883, 16014893, 16043828, 16052218, 16105816, 16140420, 16199108, 16204011, 16382114, 16407879, 16467080, 16533793, 16613660, 16619582, 16778591, 16863509, 16870303, 17060940, 17085664, 17186532, 17192868, 17192902, 17233841, 17238183, 17285735, 17321325, 17332333, 17368623, 17409930, 17473653, 17487277, 17505415, 17537621, 17561305, 17565015, 17573511, 17580276, 17626639, 17784875, 17785547, 17904685, 17917328, 17941001, 17945377, 17973572, 18061305, 18089646, 18176089, 18186961, 18202784, 18208799, 18258923, 18261621, 18271876, 18334834, 18372921, 18403609, 18428421, 18448188, 18676744, 18948947, 18985444, 19002495, 19010870, 19020901, 19063875, 19096301
ENSP00000275493C311SBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000345973V323IBIOMARTchronic lymphocytic leukemia21930507, 21930502
ENSP00000275493C326YTCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000275493LeukemiaNormal vs. Cancercell lineDown0.4517022645
ENSP00000275493LeukemiaNormal vs. Cancercell lineUp5.717022645

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y1016DVVDADEyLIPQQGFglioblastoma multiforme17575160PhosphoSitePlus
Y1016DVVDADEyLIPQQGFnon-small cell lung cancer19002495PhosphoSitePlus
Y1197STAENAEyLRVAPQSnon-small cell lung cancer19002495PhosphoSitePlus
Y869Pkinase_TyrLGAEEKEyHAEGGKVnon-small cell large cell lung carcinoma; non-small cell squamous cell lung carcinoma16505275PhosphoSitePlus
Y869Pkinase_TyrLGAEEKEyHAEGGKVhepatocellular carcinoma16936701PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
HBEGF_HUMANEGFR_HUMANligand -> receptorHPMR
EREG_HUMANEGFR_HUMANligand -> receptorHPMR
EGF_HUMANEGFR_HUMANligand -> receptorHPMR
TGFA_HUMANEGFR_HUMANligand -> receptorHPMR
BTC_HUMANEGFR_HUMANligand -> receptorHPMR
AREG_HUMANEGFR_HUMANligand -> receptorHPMR
EGFR_HUMANRGS16_HUMANkinase -> substrateRegPhos
EGFR_HUMAN41_HUMANkinase -> substrateHPRD; RegPhos
EGFR_HUMANVAV2_HUMANkinase -> substrateRegPhos
ERBB2_HUMANEGFR_HUMANkinase -> substrateHPRD
EGFR_HUMANCTND1_HUMANkinase -> substrateHPRD; RegPhos
EGFR_HUMANSTA5A_HUMANkinase -> substrateKEGG
EGFR_HUMANPTN1_HUMANkinase -> substrateHPRD; RegPhos
EGFR_HUMANIPKA_HUMANkinase -> substrateHPRD; RegPhos
EGFR_HUMANSCAM1_HUMANkinase -> substrateHPRD; RegPhos
EGFR_HUMANCRK_HUMANkinase -> substrateKEGG; HPRD; RegPhos
EGFR_HUMANRASA1_HUMANkinase -> substrateHPRD; RegPhos
KPCA_HUMANEGFR_HUMANkinase -> substrateRobert H Newman (2013)
EGFR_HUMANEPS15_HUMANkinase -> substrateHPRD; RegPhos
EGFR_HUMANEZRI_HUMANkinase -> substrateRegPhos
JAK2_HUMANEGFR_HUMANkinase -> substrateHPRD; RegPhos
EGFR_HUMANGRB2_HUMANkinase -> substrateHPRD; RegPhos
EGFR_HUMANEGFR_HUMANkinase -> substrateRegPhos
EGFR_HUMANERBB2_HUMANkinase -> substrateHPRD; RegPhos
EGFR_HUMANCALM_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANEGFR_HUMANkinase -> substrateRegPhos
CDK1_HUMANEGFR_HUMANkinase -> substrateRegPhos
EGFR_HUMANANXA1_HUMANkinase -> substrateRegPhos
ANPRB_HUMANEGFR_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANEGFR_HUMANkinase -> substrateRegPhos
MK03_HUMANEGFR_HUMANkinase -> substrateRobert H Newman (2013)
EGFR_HUMANCBL_HUMANkinase -> substrateRegPhos
EGFR_HUMANHGS_HUMANkinase -> substrateHPRD; RegPhos
EGFR_HUMANSCAM3_HUMANkinase -> substrateHPRD; RegPhos
AVR2B_HUMANEGFR_HUMANkinase -> substrateRobert H Newman (2013)
EGFR_HUMANSTAM2_HUMANkinase -> substrateHPRD; RegPhos
EGFR_HUMANSTA5B_HUMANkinase -> substrateRegPhos
KCC2A_HUMANEGFR_HUMANkinase -> substrateHPRD
EGFR_HUMANPLD2_HUMANkinase -> substrateHPRD; RegPhos
CLK2_HUMANEGFR_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANEGFR_HUMANkinase -> substrateRobert H Newman (2013)
EGFR_HUMANSTAT1_HUMANkinase -> substrateHPRD; RegPhos
EGFR_HUMANMUC1_HUMANkinase -> substrateHPRD; RegPhos
EGFR_HUMANMYL9_HUMANkinase -> substrateRegPhos
KCC2G_HUMANEGFR_HUMANkinase -> substrateHPRD
KPCD_HUMANEGFR_HUMANkinase -> substrateHPRD
EGFR_HUMANPLCG1_HUMANkinase -> substrateRegPhos
EGFR_HUMANGAB1_HUMANkinase -> substrateRegPhos
EGFR_HUMANSHC2_HUMANkinase -> substrateKEGG
MK01_HUMANEGFR_HUMANkinase -> substrateRobert H Newman (2013)
PTN11_HUMANEGFR_HUMANphosphatase -> substrateHPRD
PTN6_HUMANEGFR_HUMANphosphatase -> substrateHPRD
HBEGF_HUMANEGFR_HUMANotherKEGG
BTC_HUMANEGFR_HUMANotherKEGG
EGFR_HUMANSRC_HUMANotherKEGG
EGFR_HUMANGRB2_HUMANotherKEGG
TGFA_HUMANEGFR_HUMANotherKEGG
EGFR_HUMANSHC2_HUMANotherKEGG
EGFR_HUMANPLCG1_HUMANotherKEGG
EGFR_HUMANPI3R5_HUMANotherKEGG
EGFR_HUMANSOS1_HUMANotherKEGG
EGF_HUMANEGFR_HUMANotherKEGG
EGFR_HUMANFAK1_HUMANotherKEGG
AREG_HUMANEGFR_HUMANotherKEGG
EREG_HUMANEGFR_HUMANotherKEGG
RXRA_HUMANEGFR_HUMANTF -> target geneTRANSFAC
THB_HUMANEGFR_HUMANTF -> target geneTRANSFAC
EGR1_HUMANEGFR_HUMANTF -> target geneTRANSFAC
SP1_HUMANEGFR_HUMANTF -> target geneTRANSFAC
GCFC2_HUMANEGFR_HUMANTF -> target geneTRANSFAC
P53_HUMANEGFR_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04020Calcium signaling pathway
hsa04510Focal adhesion
hsa05223Non-small cell lung cancer
hsa04520Adherens junction
hsa04144Endocytosis
hsa04540Gap junction
hsa04010MAPK signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04912GnRH signaling pathway
hsa05212Pancreatic cancer
hsa05160Hepatitis C
hsa05200Pathways in cancer
hsa05219Bladder cancer
hsa04810Regulation of actin cytoskeleton
hsa05214Glioma
hsa05213Endometrial cancer
hsa04320Dorso-ventral axis formation
hsa05215Prostate cancer
hsa04012ErbB signaling pathway
hsa05218Melanoma

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001503ossificationNASbiological_process
GO:0070141response to UV-AIDAbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actTASmolecular_function
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0005768endosomeIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0042802identical protein bindingIPImolecular_function
GO:0000186activation of MAPKK activityNASbiological_process
GO:0005006epidermal growth factor-activated receptor activitIEAmolecular_function
GO:0051015actin filament bindingIDAmolecular_function
GO:0019899enzyme bindingIPImolecular_function
GO:0000139Golgi membraneIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0004888transmembrane signaling receptor activityIDAmolecular_function
GO:0035413positive regulation of catenin import into nucleusIMPbiological_process
GO:0030139endocytic vesicleIEAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0004713protein tyrosine kinase activityIMPmolecular_function
GO:0046982protein heterodimerization activityIDAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005615extracellular spaceNAScellular_component
GO:0001892embryonic placenta developmentIEAbiological_process
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0070435Shc-EGFR complexISScellular_component
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0042177negative regulation of protein catabolic processIDAbiological_process
GO:0031659positive regulation of cyclin-dependent protein kiIDAbiological_process
GO:0000902cell morphogenesisIEAbiological_process
GO:0003690double-stranded DNA bindingNASmolecular_function
GO:0051205protein insertion into membraneTASbiological_process
GO:0050679positive regulation of epithelial cell proliferatiIEAbiological_process
GO:0030122AP-2 adaptor complexTAScellular_component
GO:0007411axon guidanceTASbiological_process
GO:0004709MAP kinase kinase kinase activityNASmolecular_function
GO:0030335positive regulation of cell migrationIMPbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0050999regulation of nitric-oxide synthase activityIDAbiological_process
GO:0004716receptor signaling protein tyrosine kinase activitIEAmolecular_function
GO:0043406positive regulation of MAP kinase activityIDAbiological_process
GO:0031965nuclear membraneIEAcellular_component
GO:0007435salivary gland morphogenesisIEAbiological_process
GO:0006950response to stressNASbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0046777protein autophosphorylationIEAbiological_process
GO:0008283cell proliferationIDAbiological_process
GO:0019903protein phosphatase bindingIPImolecular_function
GO:0000165MAPK cascadeNASbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0051897positive regulation of protein kinase B signaling IMPbiological_process
GO:0021795cerebral cortex cell migrationIEAbiological_process
GO:0016337cell-cell adhesionIMPbiological_process
GO:0048546digestive tract morphogenesisIEAbiological_process
GO:0048146positive regulation of fibroblast proliferationIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0007165signal transductionIDAbiological_process
GO:0007166cell surface receptor signaling pathwayIDAbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0008544epidermis developmentIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0045121membrane raftIDAcellular_component
GO:0043006activation of phospholipase A2 activity by calciumTASbiological_process
GO:0045739positive regulation of DNA repairIDAbiological_process
GO:0016301kinase activityIEAmolecular_function
GO:0045740positive regulation of DNA replicationIDAbiological_process
GO:0042327positive regulation of phosphorylationIDAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0030235nitric-oxide synthase regulator activityIDAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0007165signal transductionIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0010008endosome membraneIEAcellular_component
GO:0045429positive regulation of nitric oxide biosynthetic pIDAbiological_process
GO:0060571morphogenesis of an epithelial foldIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0042059negative regulation of epidermal growth factor recTASbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0016020membraneIDAcellular_component
GO:0007173epidermal growth factor receptor signaling pathwayIEAbiological_process
GO:0050730regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0001942hair follicle developmentIEAbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayIDAbiological_process