Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:STK11_HUMAN
Description:serine/threonine kinase 11 [Source:HGNC Symbol;Acc:11389]
Location:chr19 p13.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S428KIRRLsACKRPS6KB1HPRD
T189LTTGGtLKISDSTK11HPRD
S428KIRRLsACKQQMSK1RegPhos
S31IHRIDsTEVIYPhosphoSitePlus; HPRD; RegPhos
T32HRIDStEVIYQPhosphoSitePlus; HPRD
S428KIRRLsACKRPS6KA5HPRD
Y36STEVIyQPRRKPhosphoSitePlus
S428KIRRLsACKQQPhosphoSitePlus
S428KIRRLsACKQQPKA_groupRegPhos
T363DDIIYtQDFTVATMHPRD; phosphoELM; RegPhos
T189LTTGGtLKISDLKB1phosphoELM; RegPhos
S428KIRRLsACKQQPKACaRegPhos
S428KIRRLsACKRPS6KA3HPRD
T402AAQLStKSRAEPhosphoSitePlus
S428KIRRLsACKQQp70S6KRegPhos
S428KIRRLsACKQQRSK2RegPhos
T189LTTGGtLKISDPkinasePhosphoSitePlus
T363DDIIYtQDFTVautocatalysisRegPhos
S428KIRRLsACKRSK_groupphosphoELM
S428KIRRLsACKQQRSK_groupRegPhos
S325VPIPPsPDTKDHPRD; RegPhos
T336RWRSMtVVPYLPhosphoSitePlus; HPRD; RegPhos
S307QIRQHsWFRKKPkinasePhosphoSitePlus
T189LTTGGtLKISDLKB1(STK11RegPhos
T185GNLLLtTGGTLPkinasePhosphoSitePlus
T336RWRSMtVVPYLautocatalysisRegPhos
T363DDIIYtQDFTVPhosphoSitePlus
S240KVDIWsAGVTLPkinasePhosphoSitePlus
S428KIRRLsACKPRKACAHPRD

Dephosphorylation site
STK11_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000324856S232PHPIOther Cancer19892943
ENSP00000324856D208NHPIColorectal Cancer9731485
ENSP00000324856Q37*Ding2008, Greenman2007Lung Cancer12097271, 15021901, 16140923, 17344846, 17711506, 18428421, 18948947
ENSP00000324856G215DHPIColorectal Cancer9731485
ENSP00000324856D176YHPIOther Cancer12805220 19892943
ENSP00000324856L285QHPIOther Cancer19892943
ENSP00000324856A205THPIOther Cancer19892943
ENSP00000324856R304GDing2008Lung Cancer18948947
ENSP00000324856D277YHPIOther Cancer19892943
ENSP00000324856P281LHPIOvarian Cancer10429654
ENSP00000324856T367MHPIColorectal Cancer9731485
ENSP00000324856Q170*Ding2008Lung Cancer10208439, 18428421, 18549475, 18948947
ENSP00000324856P324LHPIGastric Cancer9683800
ENSP00000324856I177NHPIOther Cancer19892943
ENSP00000324856E14KHPIUterine Cancer12533684
ENSP00000324856L160PHPIUterine Cancer12533684
ENSP00000324856Q137*Ding2008Lung Cancer18948947
ENSP00000324856*434YCOSMICOvarian Cancer20826764
ENSP00000324856R86GHPIOther Cancer19892943
ENSP00000324856G171SHPIColorectal Cancer19892943 9731485
ENSP00000324856A389TDing2008Lung Cancer18948947
ENSP00000324856G242VDing2008Lung Cancer18948947
ENSP00000324856G56WDing2008Lung Cancer18948947
ENSP00000324856Y60*Ding2008Lung Cancer15077168, 18428421, 18948947
ENSP00000324856Q170PHPIOther Cancer19892943
ENSP00000324856Q37LDing2008Lung Cancer18948947
ENSP00000324856S216FHPIOther Cancer19892943
ENSP00000324856Q220*Ding2008Lung Cancer18428421, 18948947
ENSP00000324856Q159*Ding2008Lung Cancer18428421, 18594528, 18948947
ENSP00000324856H174RHPIOther Cancer19892943
ENSP00000324856T250PHPIOther Cancer19892943
ENSP00000324856Q123RHPIOther Cancer19892943
ENSP00000324856F157SHPIOther Cancer19892943
ENSP00000324856V66MHPIUterine Cancer19892943 12533684
ENSP00000324856P314HHPIColorectal Cancer9809980
ENSP00000324856G196VDing2008Lung Cancer18948947
ENSP00000324856D237YDing2008Lung Cancer18948947
ENSP00000324856E165*Ding2008Lung Cancer18948947
ENSP00000324856T230PHPIOther Cancer19892943
ENSP00000324856G163DOMIM, HPITesticular Cancer9605748 9887330, 19892943 9605748 9887330
ENSP00000324856G91LDing2008Lung Cancer18948947
ENSP00000324856K78EDing2008Lung Cancer18948947
ENSP00000324856K191*Ding2008Lung Cancer18948947
ENSP00000324856D194VHPILung Cancer10079245
ENSP00000324856E223VHPIOther Cancer19892943
ENSP00000324856N181EHPIOther Cancer19892943
ENSP00000324856Q170*Ding2008Skin Cancer10208439, 18428421, 18549475, 18948947
ENSP00000324856E199QHPIOther Cancer19892943
ENSP00000324856Y272HHPIOther Cancer19892943
ENSP00000324856F354LHPIColorectal Cancer9731485
ENSP00000324856F231LHPIUterine Cancer12533684
ENSP00000324856Q220*Ding2008Uterine Cancer18428421, 18948947
ENSP00000324856R87KGreenman2007Skin Cancer17344846, 18428421
ENSP00000324856L245RHPIOther Cancer19892943
ENSP00000324856E199*Ding2008Lung Cancer18428421, 18948947

Differential expressed protein
STK11_HUMAN is not differential expressed protein.

Hyperphosphorylation site
STK11_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STK11_HUMANNEIL2_HUMANkinase -> substrateRobert H Newman (2013)
STK11_HUMANNUAK1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
STK11_HUMANSTRAA_HUMANkinase -> substrateRegPhos
STK11_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
STK11_HUMANTRI14_HUMANkinase -> substrateRobert H Newman (2013)
ATM_HUMANSTK11_HUMANkinase -> substrateHPRD; RegPhos
KPCA_HUMANSTK11_HUMANkinase -> substrateHPRD
STK11_HUMANRNF4_HUMANkinase -> substrateRobert H Newman (2013)
STK11_HUMANTAF10_HUMANkinase -> substrateRobert H Newman (2013)
STK11_HUMANMARK3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
STK11_HUMANTSNAX_HUMANkinase -> substrateRobert H Newman (2013)
STK11_HUMANMARK1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
STK11_HUMANBRSK1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
STK11_HUMANAAPK2_HUMANkinase -> substrateRegPhos
STK11_HUMANSTK11_HUMANkinase -> substrateHPRD; RegPhos
STK11_HUMANMARK2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KS6A3_HUMANSTK11_HUMANkinase -> substrateHPRD; RegPhos
STK11_HUMANMARK4_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
STK11_HUMANAAPK1_HUMANkinase -> substrateKEGG; RegPhos; Robert H Newman (2013)
STK11_HUMANARBK1_HUMANkinase -> substrateRobert H Newman (2013)
STK11_HUMANPTEN_HUMANkinase -> substrateHPRD; RegPhos
STK11_HUMANBAD_HUMANkinase -> substrateRobert H Newman (2013)
STK11_HUMANBRSK2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
STK11_HUMANPFD5_HUMANkinase -> substrateRobert H Newman (2013)
STK11_HUMANSIK2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
STK11_HUMANSMAD2_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANSTK11_HUMANkinase -> substrateRegPhos
STK11_HUMANSAFB2_HUMANkinase -> substrateRobert H Newman (2013)
STK11_HUMANMELK_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
STK11_HUMANSCG1_HUMANkinase -> substrateRobert H Newman (2013)
STK11_HUMANNUAK2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KS6A5_HUMANSTK11_HUMANkinase -> substrateHPRD; RegPhos
STK11_HUMANSNRK_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
STK11_HUMANVIGLN_HUMANkinase -> substrateRobert H Newman (2013)
STK11_HUMANTRIP4_HUMANkinase -> substrateRobert H Newman (2013)
STK11_HUMANSIK3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KS6B1_HUMANSTK11_HUMANkinase -> substrateHPRD
STK11_HUMANSIK1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
STK11_HUMANTFE3_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04920Adipocytokine signaling pathway
hsa04150mTOR signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0001558regulation of cell growthIEAbiological_process
GO:0030295protein kinase activator activityIDAmolecular_function
GO:0001894tissue homeostasisIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030308negative regulation of cell growthISSbiological_process
GO:0030511positive regulation of transforming growth factor IMPbiological_process
GO:0001944vasculature developmentISSbiological_process
GO:0051896regulation of protein kinase B signaling cascadeIEAbiological_process
GO:0007286spermatid developmentIEAbiological_process
GO:0045860positive regulation of protein kinase activityIDAbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0006914autophagyIEAbiological_process
GO:0060070canonical Wnt receptor signaling pathwayIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0033762response to glucagon stimulusIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0010212response to ionizing radiationIEAbiological_process
GO:0006974response to DNA damage stimulusIEAbiological_process
GO:0043434response to peptide hormone stimulusIEAbiological_process
GO:0030275LRR domain bindingIEAmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0051645Golgi localizationIEAbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0033993response to lipidIEAbiological_process
GO:0001944vasculature developmentIEAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0060770negative regulation of epithelial cell proliferatiIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0072332intrinsic apoptotic signaling pathway by p53 classIDAbiological_process
GO:0010212response to ionizing radiationISSbiological_process
GO:0043234protein complexIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0042304regulation of fatty acid biosynthetic processTASbiological_process
GO:0050772positive regulation of axonogenesisIEAbiological_process
GO:0002039p53 bindingIDAmolecular_function
GO:0016020membraneISScellular_component
GO:0006112energy reserve metabolic processTASbiological_process
GO:0051291protein heterooligomerizationIEAbiological_process
GO:0030010establishment of cell polarityIEAbiological_process
GO:0046320regulation of fatty acid oxidationTASbiological_process
GO:0043276anoikisIMPbiological_process
GO:0042593glucose homeostasisIEAbiological_process
GO:0030111regulation of Wnt receptor signaling pathwayIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0030010establishment of cell polarityISSbiological_process
GO:0007409axonogenesisIEAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0008285negative regulation of cell proliferationIMPbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0007050cell cycle arrestIDAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0001558regulation of cell growthISSbiological_process
GO:0042593glucose homeostasisISSbiological_process
GO:0045722positive regulation of gluconeogenesisIEAbiological_process
GO:0005739mitochondrionIDAcellular_component
GO:0016020membraneIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0005829cytosolISScellular_component
GO:0030308negative regulation of cell growthIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008286insulin receptor signaling pathwayTASbiological_process