Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HIF1A_HUMAN
Description:hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Source:HGNC Symbol;Acc:4910]
Location:chr14 q23.2
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S668QSRTAsPNRAGPhosphoSitePlus
S653HKETTsATSSPPhosphoSitePlus
S657TSATSsPYRDTPhosphoSitePlus
S643LIASPsPTHIHPhosphoSitePlus
S641KILIAsPSPTHPhosphoSitePlus
S576DFQLRsFDQLSHIF-1PhosphoSitePlus
T796GLPQLtSYDCEHIF-1a_CTADPhosphoSitePlus
S696LSVALsQRTTVPhosphoSitePlus
S247FLSRHsLDMKFPhosphoSitePlus
T652IHKETtSATSSPhosphoSitePlus
T796GLPQLtSYDCECK2a1-rsRegPhos
T796GLPQLtSYDCECSNK2A1HPRD
S113DMIYIsDNVNKPASPhosphoSitePlus
Y66RLTISyLRVRKHLHPhosphoSitePlus
T796GLPQLtSYDCEphosphoELM; RegPhos
T651HIHKEtTSATSPhosphoSitePlus
T796GLPQLtSYDCECK2a1RegPhos

Dephosphorylation site
HIF1A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000338018Q697ECOSMICLung Cancer
ENSP00000338018S727*COSMICRenal Cancer
ENSP00000338018N707fs*5COSMICRenal Cancer20054297

Differential expressed protein
HIF1A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HIF1A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANHIF1A_HUMANkinase -> substrateHPRD
MTOR_HUMANHIF1A_HUMANkinase -> substrateKEGG
SRPK2_HUMANHIF1A_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANHIF1A_HUMANkinase -> substrateRegPhos
MK11_HUMANHIF1A_HUMANkinase -> substrateRobert H Newman (2013)
HIF1A_HUMANVEGFD_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05211Renal cell carcinoma
hsa05200Pathways in cancer
hsa04150mTOR signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolTAScellular_component
GO:0019901protein kinase bindingIPImolecular_function
GO:0008134transcription factor bindingIPImolecular_function
GO:0046716muscle cell homeostasisIEAbiological_process
GO:0043619regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0010573vascular endothelial growth factor productionIDAbiological_process
GO:0005667transcription factor complexIPIcellular_component
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0002248connective tissue replacement involved in inflammaIEAbiological_process
GO:0000988protein binding transcription factor activityIEAmolecular_function
GO:0060574intestinal epithelial cell maturationIEAbiological_process
GO:0032963collagen metabolic processISSbiological_process
GO:0010634positive regulation of epithelial cell migrationIEAbiological_process
GO:0000988protein binding transcription factor activityIDAmolecular_function
GO:0032364oxygen homeostasisIEAbiological_process
GO:0001666response to hypoxiaIDAbiological_process
GO:0043565sequence-specific DNA bindingIDAmolecular_function
GO:0010634positive regulation of epithelial cell migrationISSbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0032007negative regulation of TOR signaling cascadeIEAbiological_process
GO:0071456cellular response to hypoxiaIDAbiological_process
GO:0035035histone acetyltransferase bindingIPImolecular_function
GO:0003151outflow tract morphogenesisIEAbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0002248connective tissue replacement involved in inflammaISSbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0003208cardiac ventricle morphogenesisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIMPbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0006879cellular iron ion homeostasisIEAbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0051879Hsp90 protein bindingIDAmolecular_function
GO:0021502neural fold elevation formationIEAbiological_process
GO:0001077RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0033554cellular response to stressTASbiological_process
GO:0045648positive regulation of erythrocyte differentiationIEAbiological_process
GO:0061030epithelial cell differentiation involved in mammarIEAbiological_process
GO:0010575positive regulation vascular endothelial growth faIDAbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0032963collagen metabolic processIEAbiological_process
GO:0001837epithelial to mesenchymal transitionISSbiological_process
GO:0045821positive regulation of glycolysisICbiological_process
GO:0045648positive regulation of erythrocyte differentiationICbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0001568blood vessel developmentIEAbiological_process
GO:0001947heart loopingIEAbiological_process
GO:0010468regulation of gene expressionIDAbiological_process
GO:0048546digestive tract morphogenesisIEAbiological_process
GO:0071347cellular response to interleukin-1IEPbiological_process
GO:0006089lactate metabolic processIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0061298retina vasculature development in camera-type eyeIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIGIbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0032722positive regulation of chemokine productionTASbiological_process
GO:0051541elastin metabolic processISSbiological_process
GO:0002052positive regulation of neuroblast proliferationIEAbiological_process
GO:0006110regulation of glycolysisIEAbiological_process
GO:0001892embryonic placenta developmentIEAbiological_process
GO:0035162embryonic hemopoiesisIEAbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIDAmolecular_function
GO:0042541hemoglobin biosynthetic processIEAbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0030949positive regulation of vascular endothelial growthIEAbiological_process
GO:0001922B-1 B cell homeostasisIEAbiological_process
GO:0061419positive regulation of transcription from RNA polyIMPbiological_process
GO:0014850response to muscle activityIEAbiological_process
GO:0051000positive regulation of nitric-oxide synthase activTASbiological_process
GO:0061418regulation of transcription from RNA polymerase IITASbiological_process
GO:0008542visual learningIEAbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0010870positive regulation of receptor biosynthetic proceIMPbiological_process
GO:0051541elastin metabolic processIEAbiological_process
GO:0070101positive regulation of chemokine-mediated signalinICbiological_process
GO:2001054negative regulation of mesenchymal cell apoptotic IEAbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0042789mRNA transcription from RNA polymerase II promoterICbiological_process
GO:0032909regulation of transforming growth factor beta2 proIMPbiological_process
GO:0043619regulation of transcription from RNA polymerase IIIDAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0071542dopaminergic neuron differentiationIEAbiological_process
GO:0048514blood vessel morphogenesisIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0050790regulation of catalytic activityIEAbiological_process
GO:0045926negative regulation of growthIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0030949positive regulation of vascular endothelial growthICbiological_process
GO:0030502negative regulation of bone mineralizationIEAbiological_process
GO:0001837epithelial to mesenchymal transitionIEAbiological_process
GO:0007595lactationIEAbiological_process
GO:0032364oxygen homeostasisIDAbiological_process
GO:0007165signal transductionIMPbiological_process
GO:0001755neural crest cell migrationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0001938positive regulation of endothelial cell proliferatICbiological_process
GO:0051216cartilage developmentIEAbiological_process
GO:0045766positive regulation of angiogenesisICbiological_process
GO:0001944vasculature developmentIEAbiological_process
GO:0019896axon transport of mitochondrionIMPbiological_process
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0019899enzyme bindingIPImolecular_function
GO:0042826histone deacetylase bindingIEAmolecular_function
GO:0035774positive regulation of insulin secretion involved IEAbiological_process
GO:0042593glucose homeostasisIEAbiological_process
GO:0021987cerebral cortex developmentIEAbiological_process
GO:0046886positive regulation of hormone biosynthetic procesIDAbiological_process