| UniProt/SwissProt ID: | CUX1_HUMAN |
| Description: | cut-like homeobox 1 [Source:HGNC Symbol;Acc:2557] |
| Location: | chr7 q22.1 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S1100 | PPASDsQPTTP | PhosphoSitePlus | |
| S1237 | YSQGAsPQPQH | PhosphoSitePlus | |
| S1233 | VGTEYsQGASP | PhosphoSitePlus; HPRD | |
| S391 | LEKNRsLQSEN | HPRD | |
| S1216 | KRRHSsVSDSQ | PhosphoSitePlus | |
| S1059 | SPAPEsPMSSS | HPRD | |
| S755 | PMPTVsSYPPL | PhosphoSitePlus | |
| S409 | SDLSGsARRKG | HPRD | |
| S585 | GLSQGsVSEIL | CUT | PhosphoSitePlus |
| S768 | SLKKPsAAPEA | PhosphoSitePlus | |
| S749 | KLLSTsPMPTV | HPRD | |
| T739 | SQSDItILTPK | PhosphoSitePlus | |
| S1454 | APRRPsSLQSL | PhosphoSitePlus; HPRD; phosphoELM | |
| T1103 | SDSQPtTPLPL | PhosphoSitePlus | |
| T374 | SEGAGtQDAAK | PhosphoSitePlus | |
| S1458 | PSSLQsLFGLP | PhosphoSitePlus | |
| S1404 | PGPLPsPASAT | PhosphoSitePlus | |
| S756 | MPTVSsYPPLA | PhosphoSitePlus | |
| S369 | MEFAPsEGAGT | PhosphoSitePlus | |
| S1237 | YSQGAsPQPQH | CDK1 | HPRD; phosphoELM |
| S663 | TRIRAsETGSD | PhosphoSitePlus; HPRD | |
| Y351 | KGQADyEEVKK | NPV_P10 | PhosphoSitePlus |
| T1104 | DSQPTtPLPLS | PhosphoSitePlus | |
| S734 | KQAPLsQSDIT | PhosphoSitePlus; HPRD | |
| S1270 | QKPYPsPKTIE | CDK1 | HPRD; phosphoELM |
| S322 | RENSAsQISQL | HPRD | |
| T665 | IRASEtGSDEA | PhosphoSitePlus; HPRD | |
| S763 | PPLAIsLKKPS | PhosphoSitePlus; HPRD | |
| S1270 | QKPYPsPKTIE | Homeobox | PhosphoSitePlus |
| Y1232 | SVGTEySQGAS | PhosphoSitePlus; HPRD | |
| S363 | LNILKsMEFAP | NPV_P10 | PhosphoSitePlus |
| S322 | RENSAsQISQL | NPV_P10 | PhosphoSitePlus |
| S667 | ASETGsDEAIK | PhosphoSitePlus; HPRD | |
| Y889 | SAESPySQSSE | PhosphoSitePlus | |
| S868 | PRAERsQLQGP | PhosphoSitePlus | |
| T1380 | PPPSGtPGPDD | PhosphoSitePlus | |
| S452 | GTHQFsPAGLS | HPRD; phosphoELM | |
| T742 | DITILtPKLLS | PhosphoSitePlus | |
| S974 | KVLGLsQGSVS | HPRD | |
| S874 | QLQGPsSSEYW | PhosphoSitePlus | |
| S887 | WPSAEsPYSQS | PhosphoSitePlus | |
| T1352 | PGSADtEEPKS | PhosphoSitePlus | |
| S1054 | TSASCsPAPES | HPRD | |
| T1071 | SVKSLtELVQQ | HPRD | |
| S467 | SSSLAsPSLPL | PhosphoSitePlus; HPRD; phosphoELM | |
| S1218 | RHSSVsDSQPC | PhosphoSitePlus; HPRD | |
| T1157 | TILGLtQGSVS | CUT | PhosphoSitePlus |
| S1357 | TEEPKsQGEAE | PhosphoSitePlus; HPRD | |
| S1215 | MKRRHsSVSDS | PKA_group | phosphoELM |
| S1455 | PRRPSsLQSLF | PhosphoSitePlus | |
| S1215 | MKRRHsSVSDS | PhosphoSitePlus | |
| S1496 | LEKAAsREEPI | PhosphoSitePlus; HPRD; phosphoELM | |
| S1312 | EIQAGsQGQAG | PhosphoSitePlus; HPRD | |
| S59 | APLLKsFQGEI | PhosphoSitePlus | |
| T600 | PWNKLtVRGKE | CUT | PhosphoSitePlus |
| Dephosphorylation site |
| CUX1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000292535 | A769T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000353401 | L652V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000353401 | R672L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000292535 | P1055T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000292535 | D14V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000353401 | D25V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000292535 | R661L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000292535 | E136K | COSMIC | Pancreatic Cancer | ENSP00000353401 | A780T | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000292535 | L641V | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| CUX1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CUX1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK1_HUMAN | CUX1_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | CUX1_HUMAN | kinase -> substrate | RegPhos |
| CUX1_HUMAN | HBG1_HUMAN | TF -> target gene | TRANSFAC |
| CUX1_HUMAN | CY24B_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| CUX1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0003682 | chromatin binding | IEA | molecular_function |
| GO:0042491 | auditory receptor cell differentiation | IEA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0030674 | protein binding, bridging | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0000301 | retrograde transport, vesicle recycling within Gol | IEA | biological_process |
| GO:0030324 | lung development | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0006357 | regulation of transcription from RNA polymerase II | TAS | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0007275 | multicellular organismal development | TAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |