Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FGF23_HUMAN
Description:fibroblast growth factor 23 [Source:HGNC Symbol;Acc:3680]
Location:chr12 p13.32
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y51TARNSyHLQIHFGFPhosphoSitePlus
Y70PHQTIySALMIFGFPhosphoSitePlus
S71HQTIYsALMIRFGFPhosphoSitePlus

Dephosphorylation site
FGF23_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000237837M96TOMIMOther Cancer16151858
ENSP00000237837A197VCOSMICSkin Cancer21984974
ENSP00000237837S129FOMIMOther Cancer16030159
ENSP00000237837G139DCOSMICBreast Cancer20668451
ENSP00000237837S71GOMIM, HPIOther Cancer15590700, 15590700 19837926 18682534 16868048 15687325 16151858 15961556
ENSP00000237837R140WCOSMICOvarian Cancer21720365

Differential expressed protein
FGF23_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FGF23_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FGF23_HUMANFGFR4_HUMANligand -> receptorHPMR
FGF23_HUMANFGFR2_HUMANligand -> receptorHPMR
FGF23_HUMANFGFR1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa05218Melanoma
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0044421extracellular region partIEAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0055062phosphate ion homeostasisIMPbiological_process
GO:0046888negative regulation of hormone secretionISSbiological_process
GO:0030643cellular phosphate ion homeostasisIEAbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0046888negative regulation of hormone secretionIEAbiological_process
GO:0045668negative regulation of osteoblast differentiationIDAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0005105type 1 fibroblast growth factor receptor bindingIEAmolecular_function
GO:0010980positive regulation of vitamin D 24-hydroxylase acIDAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaIEAbiological_process
GO:0030502negative regulation of bone mineralizationIDAbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0005615extracellular spaceNAScellular_component
GO:0005104fibroblast growth factor receptor bindingIEAmolecular_function
GO:0042369vitamin D catabolic processIDAbiological_process
GO:0090080positive regulation of MAPKKK cascade by fibroblasIEAbiological_process
GO:0030500regulation of bone mineralizationIEAbiological_process
GO:0042359vitamin D metabolic processIEAbiological_process
GO:0030154cell differentiationNASbiological_process
GO:0006796phosphate-containing compound metabolic processIEAbiological_process
GO:0010966regulation of phosphate transportIDAbiological_process


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