Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	KS6A2_HUMAN
Description:	ribosomal protein S6 kinase, 90kDa, polypeptide 2 [Source:HGNC Symbol;Acc:10431]
Location:	chr6 q27
Node attribute:	kinase; substrate

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
S26	KSRSKsSSLSR		PhosphoSitePlus
S106	RDRVRsKMERD		HPRD
S388	LIQEPsQQDLH		PhosphoSitePlus
S226	DKRAYsFCGTI	RPS6KA2	HPRD
Y463	EILLRyGQHPN	Pkinase	PhosphoSitePlus
T574	MTPCYtANFVA	Pkinase	PhosphoSitePlus
S106	RDRVRsKMERD	Pkinase	PhosphoSitePlus
S628	LARIGsGKYAL	Pkinase	PhosphoSitePlus
T570	NGLLMtPCYTA		HPRD
S546	RDESGsPESIR	Pkinase	PhosphoSitePlus
T578	NGLLMtPCYTA		HPRD
S650	AKDVVsKMLHV	Pkinase	PhosphoSitePlus
Y135	TEGKLyLILDF	Pkinase	PhosphoSitePlus
S218	DKRAYsFCGTI		phosphoELM
T222	YSFCGtIEYMA	RPS6KA2	HPRD
S114	RDRVRsKMERD		HPRD
S30	KSSSLsRLEEE		PhosphoSitePlus
T570	NGLLMtPCYTA	Pkinase	PhosphoSitePlus
T230	YSFCGtIEYMA	RPS6KA2	HPRD
Y426	IGVGSySVCKR	Pkinase	PhosphoSitePlus
S28	RSKSSsLSRLE		PhosphoSitePlus
T618	NGPDDtPEEIL	Pkinase	PhosphoSitePlus
Y573	LMTPCyTANFV	Pkinase	PhosphoSitePlus
Y217	HDKRAySFCGT		HPRD
S377	LFRGFsFVASS	Pkinase_C	PhosphoSitePlus
T222	YSFCGtIEYMA	Pkinase	PhosphoSitePlus
S377	LFRGFsFVASS		HPRD
S27	SRSKSsSLSRL		PhosphoSitePlus
S385	LFRGFsFVASS		HPRD
Y540	PSNILyRDESG	Pkinase	PhosphoSitePlus
S381	FSFVAsSLIQE	Pkinase_C	PhosphoSitePlus
Y225	HDKRAySFCGT		HPRD
S218	DKRAYsFCGTI	RPS6KA2	HPRD
Y217	HDKRAySFCGT	Pkinase	PhosphoSitePlus
S218	DKRAYsFCGTI	Pkinase	PhosphoSitePlus

Dephosphorylation site

KS6A2_HUMAN do not have dephosphorylation site.

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000265678	S427*	Greenman2007	Lung Cancer	17344846, 18428421
ENSP00000265678	R732Q	Greenman2007	Intestines Cancer	17344846, 18428421
ENSP00000265678	R732Q	HPI	Colorectal Cancer	17344846
ENSP00000265678	E311K	Greenman2007	Skin Cancer	17344846, 18428421

Differential expressed protein

KS6A2_HUMAN is not differential expressed protein.

Hyperphosphorylation site

KS6A2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
KS6A2_HUMAN	UB2V2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	CSEN_HUMAN	kinase -> substrate	Robert H Newman (2013)
TGFR2_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	PRS7_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	EF2K_HUMAN	kinase -> substrate	RegPhos
KS6A2_HUMAN	XPO1_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	CREB1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
KS6A2_HUMAN	CSK_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	SRC8_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	ASAP2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	SIN1_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	KKCC1_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	NDUAD_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	RUVB2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	CSDC2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	BCL3_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	TF65_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	ASAP3_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	IKBA_HUMAN	kinase -> substrate	RegPhos
KS6A2_HUMAN	ESR1_HUMAN	kinase -> substrate	RegPhos
KS6A2_HUMAN	SRXN1_HUMAN	kinase -> substrate	Robert H Newman (2013)
PIM2_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	SMAD3_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	ETS1_HUMAN	kinase -> substrate	Robert H Newman (2013)
PLK1_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
M3K14_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	RNF4_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
MP2K2_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	ETV1_HUMAN	kinase -> substrate	RegPhos
KS6A2_HUMAN	PP1R8_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	SAFB2_HUMAN	kinase -> substrate	Robert H Newman (2013)
HIPK1_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	CRK_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	RUVB1_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	UB2V1_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	CTBP1_HUMAN	kinase -> substrate	Robert H Newman (2013)
ACVR1_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	MBNL3_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	NR4A2_HUMAN	kinase -> substrate	RegPhos
PRP4B_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
NEK2_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	BAD_HUMAN	kinase -> substrate	RegPhos
KS6A2_HUMAN	NR4A1_HUMAN	kinase -> substrate	RegPhos
AAPK2_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	KS6A2_HUMAN	kinase -> substrate	HPRD
KS6A2_HUMAN	SOX2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	NP1L1_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	2A5D_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	GABPA_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	CITE1_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	CSRP3_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	VCAM1_HUMAN	kinase -> substrate	HPRD; RegPhos
KS6A2_HUMAN	ZN823_HUMAN	kinase -> substrate	Robert H Newman (2013)
KGP1_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	SRF_HUMAN	kinase -> substrate	RegPhos
TESK2_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
BTK_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	S10AB_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	RBBP9_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	DDX4_HUMAN	kinase -> substrate	Robert H Newman (2013)
WNK1_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	KAT5_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	HDAC3_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	PARK7_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	MDM2_HUMAN	kinase -> substrate	Robert H Newman (2013)
HIPK4_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	1433F_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	CEBPB_HUMAN	kinase -> substrate	RegPhos
KS6A2_HUMAN	FOS_HUMAN	kinase -> substrate	RegPhos
KS6A2_HUMAN	CIP4_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	PPR3A_HUMAN	kinase -> substrate	RegPhos
KS6A2_HUMAN	GMFB_HUMAN	kinase -> substrate	RegPhos
KS6A2_HUMAN	4ET_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	DDX25_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	VHL_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	TRIP4_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A4_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KSYK_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDKL5_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KPCZ_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
SRPK2_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	RD23B_HUMAN	kinase -> substrate	Robert H Newman (2013)
DDR1_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	GCFC1_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	KS6A1_HUMAN	kinase -> substrate	RegPhos

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa04722	Neurotrophin signaling pathway
hsa04010	MAPK signaling pathway
hsa04114	Oocyte meiosis
hsa04914	Progesterone-mediated oocyte maturation
hsa04150	mTOR signaling pathway
hsa04720	Long-term potentiation

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0000287	magnesium ion binding	IEA	molecular_function
GO:0034130	toll-like receptor 1 signaling pathway	TAS	biological_process
GO:0004711	ribosomal protein S6 kinase activity	IEA	molecular_function
GO:0016773	phosphotransferase activity, alcohol group as acce	IEA	molecular_function
GO:0007507	heart development	IEA	biological_process
GO:0034142	toll-like receptor 4 signaling pathway	TAS	biological_process
GO:0018105	peptidyl-serine phosphorylation	IEA	biological_process
GO:0007165	signal transduction	NAS	biological_process
GO:0001556	oocyte maturation	IEA	biological_process
GO:0010659	cardiac muscle cell apoptotic process	IEA	biological_process
GO:0045786	negative regulation of cell cycle	IDA	biological_process
GO:0004713	protein tyrosine kinase activity	IEA	molecular_function
GO:0002755	MyD88-dependent toll-like receptor signaling pathw	TAS	biological_process
GO:0005634	nucleus	IDA	cellular_component
GO:0016772	transferase activity, transferring phosphorus-cont	IEA	molecular_function
GO:0035556	intracellular signal transduction	TAS	biological_process
GO:0002756	MyD88-independent toll-like receptor signaling pat	TAS	biological_process
GO:0005524	ATP binding	IEA	molecular_function
GO:0004674	protein serine/threonine kinase activity	TAS	molecular_function
GO:0007411	axon guidance	TAS	biological_process
GO:0016020	membrane	IEA	cellular_component
GO:0043065	positive regulation of apoptotic process	IDA	biological_process
GO:0035666	TRIF-dependent toll-like receptor signaling pathwa	TAS	biological_process
GO:0007243	intracellular protein kinase cascade	TAS	biological_process
GO:0005737	cytoplasm	IEA	cellular_component
GO:0070613	regulation of protein processing	IEA	biological_process
GO:0002224	toll-like receptor signaling pathway	TAS	biological_process
GO:0034138	toll-like receptor 3 signaling pathway	TAS	biological_process
GO:0005819	spindle	IEA	cellular_component
GO:0060047	heart contraction	IEA	biological_process
GO:0006468	protein phosphorylation	IEA	biological_process
GO:0004672	protein kinase activity	IEA	molecular_function
GO:0008063	Toll signaling pathway	TAS	biological_process
GO:0000089	mitotic metaphase	IEA	biological_process
GO:0009103	lipopolysaccharide biosynthetic process	IEA	biological_process
GO:0005515	protein binding	IEA	molecular_function
GO:0008285	negative regulation of cell proliferation	IDA	biological_process
GO:0005840	ribosome	IEA	cellular_component
GO:0045087	innate immune response	TAS	biological_process
GO:0004674	protein serine/threonine kinase activity	IEA	molecular_function
GO:0005829	cytosol	TAS	cellular_component
GO:0010628	positive regulation of gene expression	IEA	biological_process
GO:0071322	cellular response to carbohydrate stimulus	IEA	biological_process
GO:0007268	synaptic transmission	TAS	biological_process
GO:0051403	stress-activated MAPK cascade	TAS	biological_process
GO:0034134	toll-like receptor 2 signaling pathway	TAS	biological_process
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0002035	brain renin-angiotensin system	IEA	biological_process
GO:0048011	nerve growth factor receptor signaling pathway	TAS	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network