Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GATA2_HUMAN
Description:GATA binding protein 2 [Source:HGNC Symbol;Acc:4171]
Location:chr3 q21.3
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S276LGGPAsSFTPKPhosphoSitePlus
S182PPKEVsPDPSTPhosphoSitePlus; HPRD
Y376NACGLyYKLHNGATAPhosphoSitePlus
S192TTGAAsPASSSPhosphoSitePlus
Y322NACGLyHKMNGGATAPhosphoSitePlus
S73ARVSYsPAHARPhosphoSitePlus; HPRD
S401RNRKMsNKSKKAKT1HPRD
S401RNRKMsNKSKKPhosphoSitePlus
Y314DGTGHyLCNACGATAPhosphoSitePlus

Dephosphorylation site
GATA2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000417074R362QCOSMICLymphoma21399634
ENSP00000345681L359VCOSMICLymphoma18250304
ENSP00000345681P304HCOSMICLymphoma21399634
ENSP00000345681P125TCOSMICLung Cancer
ENSP00000417074S71FCOSMICMelanoma
ENSP00000417074P304HCOSMICLymphoma21399634
ENSP00000417074L359VCOSMICLymphoma18250304
ENSP00000345681R362QCOSMICLymphoma21399634
ENSP00000345681S71FCOSMICMelanoma
ENSP00000417074P125TCOSMICLung Cancer

Differential expressed protein
GATA2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GATA2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANGATA2_HUMANkinase -> substrateHPRD
GATA2_HUMANLYAM3_HUMANTF -> target geneTRANSFAC
GATA2_HUMANWT1_HUMANTF -> target geneTRANSFAC
GATA2_HUMANIL5_HUMANTF -> target geneTRANSFAC
GATA2_HUMANEDN1_HUMANTF -> target geneTRANSFAC
GATA2_HUMANEPOR_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
GATA2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0021533cell differentiation in hindbrainIEAbiological_process
GO:0006351transcription, DNA-dependentIDAbiological_process
GO:0035854eosinophil fate commitmentIDAbiological_process
GO:0045638negative regulation of myeloid cell differentiatioIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0060216definitive hemopoiesisIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0045766positive regulation of angiogenesisIEAbiological_process
GO:0021983pituitary gland developmentIEAbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0001892embryonic placenta developmentIEAbiological_process
GO:0001077RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0003682chromatin bindingIEAmolecular_function
GO:0048469cell maturationIEAbiological_process
GO:0021514ventral spinal cord interneuron differentiationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0045746negative regulation of Notch signaling pathwayIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0060872semicircular canal developmentIEAbiological_process
GO:0048663neuron fate commitmentIEAbiological_process
GO:0045650negative regulation of macrophage differentiationIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0030154cell differentiationIEAbiological_process
GO:0001709cell fate determinationIEAbiological_process
GO:0048873homeostasis of number of cells within a tissueIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0070742C2H2 zinc finger domain bindingIPImolecular_function
GO:0035019somatic stem cell maintenanceIEAbiological_process
GO:0050766positive regulation of phagocytosisIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0045599negative regulation of fat cell differentiationIEAbiological_process
GO:0000980RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0035065regulation of histone acetylationIEAbiological_process
GO:0001655urogenital system developmentIEAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0006909phagocytosisIEAbiological_process
GO:0042472inner ear morphogenesisIEAbiological_process
GO:2000178negative regulation of neural precursor cell proliIEAbiological_process
GO:0021954central nervous system neuron developmentIEAbiological_process
GO:0030182neuron differentiationIEAbiological_process
GO:0045654positive regulation of megakaryocyte differentiatiIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0007596blood coagulationTASbiological_process
GO:0070345negative regulation of fat cell proliferationIMPbiological_process
GO:0045648positive regulation of erythrocyte differentiationIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0001158enhancer sequence-specific DNA bindingIDAmolecular_function