Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SIK1_HUMAN
Description:salt-inducible kinase 1 [Source:HGNC Symbol;Acc:11142]
Location:chr21 q22.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S437RPVSPsSLLDTPhosphoSitePlus
T182GEPLStWCGSPPkinase_CAMKPhosphoSitePlus
T479LAEVStRLSPLPhosphoSitePlus; HPRD
S575EGRRAsDTSLTPhosphoSitePlus
T460EEEQDtQESLPPhosphoSitePlus; HPRD
T182GEPLStWCGSPLKB1phosphoELM
S435RPRPVsPSSLLPhosphoSitePlus

Dephosphorylation site
SIK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000270162G211SGreenman2007, HPINeoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000270162G211SGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000270162G469DGreenman2007Skin Cancer17344846, 18428421

Differential expressed protein
SIK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SIK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SIK1_HUMANKCIP2_HUMANkinase -> substrateRobert H Newman (2013)
SIK1_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
SIK1_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
SIK1_HUMANCRTC2_HUMANkinase -> substrateHPRD
MK14_HUMANSIK1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANSIK1_HUMANkinase -> substrateRegPhos
SIK1_HUMANIRS1_HUMANkinase -> substrateRegPhos
SIK1_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
SIK1_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
STK11_HUMANSIK1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
SIK1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019901protein kinase bindingIPImolecular_function
GO:0005524ATP bindingISSmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0019901protein kinase bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0042826histone deacetylase bindingIEAmolecular_function
GO:0055007cardiac muscle cell differentiationIEAbiological_process
GO:0007049cell cycleIEAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0010830regulation of myotube differentiationIEAbiological_process
GO:0008140cAMP response element binding protein bindingISSmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0000287magnesium ion bindingISSmolecular_function
GO:0007243intracellular protein kinase cascadeISSbiological_process
GO:007188914-3-3 protein bindingIDAmolecular_function
GO:0010868negative regulation of triglyceride biosynthetic pIEAbiological_process
GO:0007346regulation of mitotic cell cycleISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0010830regulation of myotube differentiationISSbiological_process
GO:0045595regulation of cell differentiationISSbiological_process
GO:0006468protein phosphorylationISSbiological_process
GO:0002028regulation of sodium ion transportIEAbiological_process
GO:0055007cardiac muscle cell differentiationISSbiological_process
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0045595regulation of cell differentiationIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0045721negative regulation of gluconeogenesisIEAbiological_process
GO:0032792negative regulation of CREB transcription factor aIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0045721negative regulation of gluconeogenesisISSbiological_process
GO:0005634nucleusIEAcellular_component
GO:0046777protein autophosphorylationIDAbiological_process
GO:0008140cAMP response element binding protein bindingIEAmolecular_function
GO:0010868negative regulation of triglyceride biosynthetic pISSbiological_process
GO:0005634nucleusIDAcellular_component
GO:0007346regulation of mitotic cell cycleIEAbiological_process
GO:0032792negative regulation of CREB transcription factor aISSbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:2000210positive regulation of anoikisIMPbiological_process
GO:0043276anoikisIEAbiological_process
GO:0002028regulation of sodium ion transportISSbiological_process
GO:0005737cytoplasmISScellular_component