Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RARA_HUMAN
Description:retinoic acid receptor, alpha [Source:HGNC Symbol;Acc:9864]
Location:chr17 q21.2
Node attribute:gene; substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S449CSPSLsPSSNRRegPhos
S461SPATHphosphoELM
S445PPGSCsPSLSPPhosphoSitePlus; phosphoELM; RegPhos
S369RKRRPsRPHMFHormone_recepPhosphoSitePlus
S461SPATHsP____PhosphoSitePlus
S405MEIPGsMPPLIHormone_recepPhosphoSitePlus
S96CQDKSsGYHYGzf-C4PhosphoSitePlus
S77VPSPPsPPPLPPhosphoSitePlus
S461SPATHsPRegPhos
T181ESYTLtPEVGEPhosphoSitePlus; phosphoELM; RegPhos
S77VPSPPsPPPLPCDK7phosphoELM; RegPhos
S456SSNRSsPATHSRegPhos
S219SEQRVsLDIDLHormone_recepPhosphoSitePlus

Dephosphorylation site
RARA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000254066K380NTCGAOvarian Cancer21720365, 18772890
ENSP00000254066K380NCOSMICOvarian Cancer21720365
ENSP00000377649K380NCOSMICOvarian Cancer21720365
ENSP00000377649A255TCOSMICLung Cancer
ENSP00000254066A255TCOSMICLung Cancer
ENSP00000377649K380NTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
RARA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RARA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANRARA_HUMANkinase -> substrateRegPhos
CDK7_HUMANRARA_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
RARA_HUMANMYH6_HUMANTF -> target geneTRANSFAC
RARA_HUMANOSTCN_HUMANTF -> target geneTRANSFAC
RARA_HUMANAPOA1_HUMANTF -> target geneTRANSFAC
RARA_HUMANRARG_HUMANTF -> target geneTRANSFAC
RARA_HUMANRARB_HUMANTF -> target geneTRANSFAC
SP1_HUMANRARA_HUMANTF -> target geneTRANSFAC
RARA_HUMANADH1G_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05202Transcriptional misregulation in cancer
hsa05221Acute myeloid leukemia
hsa05200Pathways in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030853negative regulation of granulocyte differentiationIDAbiological_process
GO:0044323retinoic acid-responsive element bindingIDAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0051018protein kinase A bindingIDAmolecular_function
GO:0030852regulation of granulocyte differentiationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0043422protein kinase B bindingIPImolecular_function
GO:0046982protein heterodimerization activityIDAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0004879ligand-activated sequence-specific DNA binding RNAIEAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0019899enzyme bindingIPImolecular_function
GO:0005102receptor bindingIDAmolecular_function
GO:0035264multicellular organism growthIEAbiological_process
GO:0045947negative regulation of translational initiationIEAbiological_process
GO:0032355response to estradiol stimulusIDAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0043401steroid hormone mediated signaling pathwayIEAbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0032689negative regulation of interferon-gamma productionIDAbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0009986cell surfaceICcellular_component
GO:0007281germ cell developmentIEAbiological_process
GO:0035014phosphatidylinositol 3-kinase regulator activityIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0071222cellular response to lipopolysaccharideIEAbiological_process
GO:0032754positive regulation of interleukin-5 productionIDAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0031490chromatin DNA bindingIDAmolecular_function
GO:0007283spermatogenesisIEAbiological_process
GO:0051897positive regulation of protein kinase B signaling IEAbiological_process
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0055012ventricular cardiac muscle cell differentiationIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0003708retinoic acid receptor activityIDAmolecular_function
GO:0006468protein phosphorylationIMPbiological_process
GO:0030520intracellular estrogen receptor signaling pathwayIDAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0071391cellular response to estrogen stimulusIDAbiological_process
GO:0007165signal transductionIDAbiological_process
GO:0071300cellular response to retinoic acidIDAbiological_process
GO:0003417growth plate cartilage developmentIEAbiological_process
GO:0001657ureteric bud developmentIEAbiological_process
GO:0032526response to retinoic acidIMPbiological_process
GO:0003713transcription coactivator activityIMPmolecular_function
GO:0060010Sertoli cell fate commitmentIEAbiological_process
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0000790nuclear chromatinIDAcellular_component
GO:0032720negative regulation of tumor necrosis factor produIDAbiological_process
GO:0048384retinoic acid receptor signaling pathwayIMPbiological_process
GO:0061037negative regulation of cartilage developmentIEAbiological_process
GO:0003708retinoic acid receptor activityIEAmolecular_function
GO:0003707steroid hormone receptor activityIEAmolecular_function
GO:0060591chondroblast differentiationIEAbiological_process
GO:0030522intracellular receptor mediated signaling pathwayIEAbiological_process
GO:0001972retinoic acid bindingIDAmolecular_function
GO:0043277apoptotic cell clearanceIMPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0045596negative regulation of cell differentiationIEAbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaIEAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0019904protein domain specific bindingIPImolecular_function
GO:0051099positive regulation of bindingIMPbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0043551regulation of phosphatidylinositol 3-kinase activiIEAbiological_process
GO:0045787positive regulation of cell cycleIMPbiological_process
GO:0048384retinoic acid receptor signaling pathwayIEAbiological_process
GO:0032526response to retinoic acidIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0032753positive regulation of interleukin-4 productionIDAbiological_process
GO:0032736positive regulation of interleukin-13 productionIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0003714transcription corepressor activityIDAmolecular_function
GO:0045630positive regulation of T-helper 2 cell differentiaIDAbiological_process