Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MLTK_HUMAN
Description:Mitogen-activated protein kinase kinase kinase MLT [Source:UniProtKB/Swiss-Prot;Acc:Q9NYL2]
Location:chr2 q31.1
Node attribute:kinase; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S754HPETDsRASEEHPRD
S687GRGSIsLNSSPPhosphoSitePlus; HPRD; SysPTM
T162FHNHTtHMSLVphosphoELM
S761ASEEDsKVSEGPhosphoSitePlus
S635VNQSRsSSPTQPhosphoSitePlus; HPRD
S781KPHRPsPAKTNPhosphoSitePlus; HPRD; SysPTM
S610FDGQDsYAAAVPhosphoSitePlus
S636NQSRSsSPTQYPhosphoSitePlus; HPRD
T628KYQQItPVNQSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S727LNPHQsPDFKRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S3GASFHPRD
S668NTDTSsERGRYPhosphoSitePlus
S302LERDLsFKEQEU3snoRNP10PhosphoSitePlus
S667GNTDTsSERGRPhosphoSitePlus; HPRD
S357VRKGDsSAEMSHPRD
S599NPILGsPFFSHPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S718KFYRVsQSALNHPRD
S136HRDLKsRNVVIPkinase_TyrPhosphoSitePlus
T161RFHNHtTHMSLphosphoELM
S584MRQIAsNTSLQPhosphoSitePlus
T162FHNHTtHMSLVPkinase_TyrPhosphoSitePlus
S302LERDLsFKEQEHPRD
Y93GSLYDyINSNRPkinase_TyrPhosphoSitePlus
S633TPVNQsRSSSPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S275PDKCNsFLHNKU3snoRNP10PhosphoSitePlus
S275PDKCNsFLHNKHPRD
S366MSVYAsLFKENSAM_1PhosphoSitePlus
S2____MsSLGASPhosphoSitePlus
S268MSNDTsLPDKCU3snoRNP10PhosphoSitePlus
S165HTTHMsLVGTFphosphoELM
Y120AKGMHyLHMEAHPRD
T161RFHNHtTHMSLPkinase_TyrPhosphoSitePlus
S660RDSGFsSGNTDPhosphoSitePlus
S568SRSDSsADCQWPhosphoSitePlus; HPRD
T586QIASNtSLQRSPhosphoSitePlus
S563DGNPGsRSDSSPhosphoSitePlus
T666SGNTDtSSERGHPRD
T704KSQHStPSRGRPhosphoSitePlus
T769SEGGWtKVEYRPhosphoSitePlus
Y715YPGKFyRVSQSHPRD
S603GSPFFsHFDGQHPRD; phosphoELM
S3___MSsLGASFPhosphoSitePlus
S637QSRSSsPTQYGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S648LTKNFsSLHLNPhosphoSitePlus; HPRD; phosphoELM
S136HRDLKsRNVVIHPRD
S557TLFTNsDGNPGPhosphoSitePlus
S268MSNDTsLPDKCHPRD
S593LQRSQsNPILGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S591TSLQRsQSNPIPhosphoSitePlus; HPRD; phosphoELM
S757TDSRAsEEDSKPhosphoSitePlus
T639RSSSPtQYGLTPhosphoSitePlus; HPRD
S733PDFKRsPRDLHPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S691ISLNSsPRGRYPhosphoSitePlus; HPRD; SysPTM
S7VQIKHPRD
Y78LEPPNyGIVTEPkinase_TyrPhosphoSitePlus
S362SSAEMsVYASLSAM_1PhosphoSitePlus
Y120AKGMHyLHMEAPkinase_TyrPhosphoSitePlus
S165HTTHMsLVGTFPkinase_TyrPhosphoSitePlus
T576CQWLDtLRMRQPhosphoSitePlus
Y696SPRGRySGKSQHPRD
S155CDFGAsRFHNHPkinase_TyrPhosphoSitePlus
Y84GIVTEyASLGSPkinase_TyrPhosphoSitePlus
S649TKNFSsLHLNSPhosphoSitePlus
S764EDSKVsEGGWTPhosphoSitePlus

Dephosphorylation site
MLTK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000387259A281TGreenman2007Ovarian Cancer17344846, 18428421
ENSP00000364361E282DDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000364361L60VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000364361F170LDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000364361A281TGreenman2007Ovarian Cancer17344846, 18428421

Differential expressed protein
MLTK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MLTK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MLTK_HUMANCHK2_HUMANkinase -> substrateRegPhos
MLTK_HUMANMP2K7_HUMANkinase -> substrateKEGG
MLTK_HUMANZO1_HUMANkinase -> substrateKEGG
ATF2_HUMANMLTK_HUMANTF -> target geneTRANSFAC
AP2A_HUMANMLTK_HUMANTF -> target geneTRANSFAC
ATF3_HUMANMLTK_HUMANTF -> target geneTRANSFAC
TFAP4_HUMANMLTK_HUMANTF -> target geneTRANSFAC
JUN_HUMANMLTK_HUMANTF -> target geneTRANSFAC
FOS_HUMANMLTK_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04530Tight junction
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007050cell cycle arrestIMPbiological_process
GO:0004709MAP kinase kinase kinase activityIEAmolecular_function
GO:0006950response to stressNASbiological_process
GO:0000075cell cycle checkpointIDAbiological_process
GO:0007257activation of JUN kinase activityIDAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0009314response to radiationIDAbiological_process
GO:0030154cell differentiationNASbiological_process
GO:0008219cell deathNASbiological_process
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0007010cytoskeleton organizationIEAbiological_process
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0000186activation of MAPKK activityTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0000077DNA damage checkpointIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0008283cell proliferationNASbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function


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