Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CDK2_HUMAN
Description:cyclin-dependent kinase 2 [Source:HGNC Symbol;Acc:1771]
Location:chr12 q13.2
Node attribute:substrate; kinase; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T14KIGEGtYGVVYPkinasePhosphoSitePlus; SysPTM
Y19TYGVVyKARNKphosphoELM; RegPhos
T160PVRTYtHEVVTPkinasePhosphoSitePlus
T160PVRTYtHEVTRHPRD
Y15IGEGTyGVVYKWee1RegPhos; SysPTM
Y19TYGVVyKARNKCDK2HPRD
S46TEGVPsTAIREPkinasePhosphoSitePlus; SysPTM
Y15IGEGTyGVVYKPkinasePhosphoSitePlus; SysPTM
T137NLLINtEGAIKPkinasePhosphoSitePlus
T158GVPVRtYTHEVPkinasePhosphoSitePlus; SysPTM
T158GVPVRtYTHEVHPRD; SysPTM
T165THEVVtLWYRAPkinasePhosphoSitePlus
T14KIGEGtYGVVYHPRD; phosphoELM; RegPhos; SysPTM
T160PVRTYtHEVVTCDK7HPRD; RegPhos
T39KIRLDtETEGVPkinasePhosphoSitePlus
Y168VVTLWyRAPEIPkinasePhosphoSitePlus
Y159VPVRTyTHEVVHPRD; phosphoELM
Y15IGEGTyGVVYKHPRD; phosphoELM; RegPhos; SysPTM
Y159VPVRTyTHEVVPkinasePhosphoSitePlus
Y179LLGCKyYSTAVPkinasePhosphoSitePlus
S46TEGVPsTAIREHPRD; SysPTM
Y19TYGVVyKARNKPkinasePhosphoSitePlus
Y15IGEGTyGVVYKWEE1 RegPhos; SysPTM
T39KIRLDtETEGVHPRD
Y15IGEGTyGVVYKWEE1HPRD; SysPTM
T160PVRTYtHEVVTCCRKRegPhos
T160PVRTYtHEVVTHPRD; phosphoELM; RegPhos
T160PVRTYtHEVVTCDK20HPRD
T160PVRTYtHEVVTDDR1(CAKRegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T160GVPVRTYtHEVTRRAPPM1BHPRD
T160GVPVRTYtHEVVTLWPPM1BHPRD
Y15EKIGEGTyGVVYKARCDC25AHPRD
T14VEKIGEGtYGVVYKACDC25AHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000266970F109LBIOMARTBreast Cancer21930507, 21930502
ENSP00000243067F109LBIOMARTBreast Cancer21930507, 21930502
ENSP00000266970P45LGreenman2007, HPINeoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000266970P45LGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421

Differential expressed protein
CDK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y15PkinaseEKIGEGTyGVVYKARcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
CDK2_HUMANFOXM1_HUMANkinase -> substrateHPRD; RegPhos
CDK2_HUMANNPM_HUMANkinase -> substrateHPRD; RegPhos
HIPK1_HUMANCDK2_HUMANkinase -> substrateRobert H Newman (2013)
CDK2_HUMANKITH_HUMANkinase -> substrateRegPhos
CDK2_HUMANMCM4_HUMANkinase -> substrateRegPhos
CDK2_HUMANCDN1B_HUMANkinase -> substrateRegPhos
CDK2_HUMANPP1A_HUMANkinase -> substrateRegPhos
CDK2_HUMANMYBB_HUMANkinase -> substrateRegPhos
CDK2_HUMANTSYL2_HUMANkinase -> substrateHPRD
CDK2_HUMANCP110_HUMANkinase -> substrateRegPhos
CDK2_HUMANPTHR_HUMANkinase -> substrateHPRD; RegPhos
CDK2_HUMANFZR_HUMANkinase -> substrateRegPhos
CDK2_HUMANCOIL_HUMANkinase -> substrateHPRD; RegPhos
CDK2_HUMANTFDP1_HUMANkinase -> substrateRegPhos
CDK2_HUMANP53_HUMANkinase -> substrateRegPhos
CDK2_HUMANRBL1_HUMANkinase -> substrateRegPhos
CDK7_HUMANCDK2_HUMANkinase -> substrateHPRD; RegPhos; NetPath
WEE1_HUMANCDK2_HUMANkinase -> substrateHPRD
CDK2_HUMANCDX2_HUMANkinase -> substrateRegPhos
CDK2_HUMANCDK7_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANCDK2_HUMANkinase -> substrateRegPhos
CDK2_HUMANPTN2_HUMANkinase -> substrateHPRD
CDK2_HUMANKAP0_HUMANkinase -> substrateRegPhos
CDK2_HUMANCDC7_HUMANkinase -> substrateHPRD
AAPK1_HUMANCDK2_HUMANkinase -> substrateRobert H Newman (2013)
CDK2_HUMANPRC1_HUMANkinase -> substrateRegPhos
CDK2_HUMANCDK2_HUMANkinase -> substrateHPRD
CDK2_HUMANCABL1_HUMANkinase -> substrateRegPhos
CDK2_HUMANRBL2_HUMANkinase -> substrateRegPhos
CDK2_HUMANID3_HUMANkinase -> substrateHPRD; RegPhos; NetPath
CDK2_HUMANCDC6_HUMANkinase -> substrateRegPhos
CDK2_HUMANORC1_HUMANkinase -> substrateRegPhos
CDK2_HUMANSF3B1_HUMANkinase -> substrateRegPhos
CDK2_HUMANUBE2A_HUMANkinase -> substrateHPRD; RegPhos
CDK2_HUMANTFDP2_HUMANkinase -> substrateRegPhos
CDK2_HUMANPRGR_HUMANkinase -> substrateRegPhos
CDK2_HUMANCDN1A_HUMANkinase -> substrateRegPhos
CDK2_HUMANNPAT_HUMANkinase -> substrateRegPhos
CDK20_HUMANCDK2_HUMANkinase -> substrateHPRD; RegPhos
CDK2_HUMANUBF1_HUMANkinase -> substrateRegPhos
CDK2_HUMANCCNE1_HUMANkinase -> substrateRegPhos
CDK2_HUMANRB_HUMANkinase -> substrateRegPhos; NetPath
CDK2_HUMANHIRA_HUMANkinase -> substrateRegPhos
CDK2_HUMANNFYA_HUMANkinase -> substrateHPRD
CDK2_HUMANP73_HUMANkinase -> substrateHPRD; RegPhos
CDK2_HUMANSMAD3_HUMANkinase -> substrateRegPhos
CDK2_HUMANESR1_HUMANkinase -> substrateRegPhos
CDK2_HUMANID2_HUMANkinase -> substrateHPRD; RegPhos; NetPath
DDR1_HUMANCDK2_HUMANkinase -> substrateRegPhos
CDK2_HUMANMYOD1_HUMANkinase -> substrateHPRD; RegPhos
CDK2_HUMANBRCA1_HUMANkinase -> substrateRegPhos
MPIP1_HUMANCDK2_HUMANphosphatase -> substrateKEGG
PPM1B_HUMANCDK2_HUMANphosphatase -> substrateHPRD
SP1_HUMANCDK2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05169Epstein-Barr virus infection
hsa04914Progesterone-mediated oocyte maturation
hsa05222Small cell lung cancer
hsa05168Herpes simplex infection
hsa04115p53 signaling pathway
hsa04110Cell cycle
hsa05203Viral carcinogenesis
hsa05215Prostate cancer
hsa05162Measles
hsa04114Oocyte meiosis
hsa05200Pathways in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0051301cell divisionIEAbiological_process
GO:0031571mitotic cell cycle G1/S transition DNA damage checTASbiological_process
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0007126meiosisTASbiological_process
GO:0051298centrosome duplicationTASbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0000278mitotic cell cycleTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0000216M/G1 transition of mitotic cell cycleTASbiological_process
GO:0051439regulation of ubiquitin-protein ligase activity inTASbiological_process
GO:0006813potassium ion transportIEAbiological_process
GO:0005813centrosomeTAScellular_component
GO:0000085G2 phase of mitotic cell cycleTASbiological_process
GO:0030332cyclin bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0005634nucleusIEAcellular_component
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000086G2/M transition of mitotic cell cycleNASbiological_process
GO:0006281DNA repairIEAbiological_process
GO:0000781chromosome, telomeric regionIEAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0060968regulation of gene silencingIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0031145anaphase-promoting complex-dependent proteasomal uTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0006977DNA damage response, signal transduction by p53 clTASbiological_process
GO:0000806Y chromosomeIEAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0035173histone kinase activityIDAmolecular_function
GO:0007067mitosisIEAbiological_process
GO:0000307cyclin-dependent protein kinase holoenzyme complexIEAcellular_component
GO:0016301kinase activityIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0007049cell cycleIEAbiological_process
GO:0007265Ras protein signal transductionIEPbiological_process
GO:0004693cyclin-dependent protein kinase activityIEAmolecular_function
GO:0015030Cajal bodyIDAcellular_component
GO:0016572histone phosphorylationIDAbiological_process
GO:0071732cellular response to nitric oxideTASbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0005768endosomeIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0032298positive regulation of DNA-dependent DNA replicatiIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0000805X chromosomeIEAcellular_component
GO:0006260DNA replicationTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0000793condensed chromosomeIEAcellular_component