Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FOS_HUMAN
Description:FBJ murine osteosarcoma viral oncogene homolog [Source:HGNC Symbol;Acc:3796]
Location:chr14 q24.3
Node attribute:TF; PPI(target); PPI(source); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S362AHRKGsSSNEPPRKACAHPRD
S362AHRKGsSSNEPPKA_groupRegPhos
Y30DSLSYyHSPADPhosphoSitePlus
T232LPEVAtPESEEErk1(MAPK3RegPhos
Y10GFNADyEASSSPhosphoSitePlus
T325LEPLCtPVVTCErk2RegPhos
T232LPEVAtPESEEErk2RegPhos
S362AHRKGsSSNEPRSK-2phosphoELM
S308WEPLHsGSLGMPhosphoSitePlus
S374SDSLSsPTLLAMAPK_groupRegPhos
T376SLSSPtLLAL_PhosphoSitePlus
T232LPEVAtPESEEMAPK3phosphoELM
T232LPEVAtPESEEPhosphoSitePlus
T331PVVTCtPSCTAPhosphoSitePlus
T116VVKTMtGGRAQDUF2514PhosphoSitePlus
T325LEPLCtPVVTCPhosphoSitePlus
S362AHRKGsSSNEPRSK_groupphosphoELM; RegPhos
T325LEPLCtPVVTCMAPK1HPRD
T325LEPLCtPVVTCMAPK3phosphoELM
T114AGVVKtMTGGRHPRD
T114AGVVKtMTGGRDUF2514PhosphoSitePlus
S374SDSLSsPTLLMAPK_groupphosphoELM
S374SDSLSsPTLLMAPK1HPRD
T232LPEVAtPESEEErk2(MAPK1RegPhos
S362AHRKGsSSNEPPhosphoSitePlus; phosphoELM
T232LPEVAtPESEEMAPK1HPRD; phosphoELM
T331PVVTCtPSCTAErk2RegPhos
T331PVVTCtPSCTAErk1(MAPK3RegPhos
S362AHRKGsSSNEPRPS6KA1HPRD
S32LSYYHsPADSFPhosphoSitePlus
S374SDSLSsPTLLAPhosphoSitePlus
S362AHRKGsSSNEPPKACaRegPhos
S363HRKGSsSNEPSPhosphoSitePlus
T325LEPLCtPVVTCErk1(MAPK3RegPhos
T331PVVTCtPSCTAMAPK1HPRD
T331PVVTCtPSCTAMAPK3phosphoELM
S374SDSLSsPTLLAErk2RegPhos
S362AHRKGsSSNEPRSK3RegPhos
S362AHRKGsSSNEPRSK2RegPhos

Dephosphorylation site
FOS_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000306245L76PDing2008, COSMICLung Cancer18948947
ENSP00000306245N245HTCGAOvarian Cancer21720365, 18772890
ENSP00000306245N245HCOSMICOvarian Cancer21720365

Differential expressed protein
FOS_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FOS_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANFOS_HUMANkinase -> substrateHPRD
KS6A1_HUMANFOS_HUMANkinase -> substrateHPRD
MK03_HUMANFOS_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANFOS_HUMANkinase -> substrateKEGG
MK01_HUMANFOS_HUMANkinase -> substrateKEGG; HPRD; Robert H Newman (2013)
KS6A2_HUMANFOS_HUMANkinase -> substrateRegPhos
KS6A3_HUMANFOS_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK09_HUMANFOS_HUMANkinase -> substrateKEGG
FOS_HUMANIL12A_HUMANotherKEGG
FOS_HUMANCCL4_HUMANotherKEGG
MK14_HUMANFOS_HUMANotherKEGG
FOS_HUMANCCND1_HUMANotherKEGG
FOS_HUMANIL8_HUMANotherKEGG
FOS_HUMANCCL3_HUMANotherKEGG
FOS_HUMANTNFA_HUMANotherKEGG
FOS_HUMANCCL5_HUMANotherKEGG
FOS_HUMANIL6_HUMANotherKEGG
FOS_HUMANIL1B_HUMANotherKEGG
RASH_HUMANFOS_HUMANotherKEGG
MK01_HUMANFOS_HUMANotherKEGG
FOS_HUMANHBB_HUMANTF -> target geneTRANSFAC
CSEN_HUMANFOS_HUMANTF -> target geneTRANSFAC
FOS_HUMANEDN1_HUMANTF -> target geneTRANSFAC
ELK3_HUMANFOS_HUMANTF -> target geneTRANSFAC
FOS_HUMANARY1_HUMANTF -> target geneTRANSFAC
STAT3_HUMANFOS_HUMANTF -> target geneTRANSFAC
GTF2I_HUMANFOS_HUMANTF -> target geneTRANSFAC
FOS_HUMANUROK_HUMANTF -> target geneTRANSFAC
SP1_HUMANFOS_HUMANTF -> target geneTRANSFAC
MYOD1_HUMANFOS_HUMANTF -> target geneTRANSFAC
ATF2_HUMANFOS_HUMANTF -> target geneTRANSFAC
AHR_HUMANFOS_HUMANTF -> target geneTRANSFAC
FOS_HUMANFOSL1_HUMANTF -> target geneTRANSFAC
FOS_HUMANDPB1_HUMANTF -> target geneTRANSFAC
FOS_HUMANIL8_HUMANTF -> target geneTRANSFAC
ETV4_HUMANFOS_HUMANTF -> target geneTRANSFAC
FOS_HUMANK1C16_HUMANTF -> target geneTRANSFAC
ELK1_HUMANFOS_HUMANTF -> target geneTRANSFAC
SRF_HUMANFOS_HUMANTF -> target geneTRANSFAC
FOS_HUMANMMP1_HUMANTF -> target geneTRANSFAC
FLI1_HUMANFOS_HUMANTF -> target geneTRANSFAC
FOS_HUMANFOS_HUMANTF -> target geneTRANSFAC
ESR1_HUMANFOS_HUMANTF -> target geneTRANSFAC
FOS_HUMANIL2_HUMANTF -> target geneTRANSFAC
TYY1_HUMANFOS_HUMANTF -> target geneTRANSFAC
FOS_HUMANMT2_HUMANTF -> target geneTRANSFAC
FOS_HUMANDRA_HUMANTF -> target geneTRANSFAC
CREB1_HUMANFOS_HUMANTF -> target geneTRANSFAC
TFE2_HUMANFOS_HUMANTF -> target geneTRANSFAC
FOS_HUMANP53_HUMANTF -> target geneTRANSFAC
FOS_HUMANWEE1_HUMANTF -> target geneTRANSFAC
FOS_HUMANMLTK_HUMANTF -> target geneTRANSFAC
ELK4_HUMANFOS_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05133Pertussis
hsa05166HTLV-I infection
hsa05132Salmonella infection
hsa04010MAPK signaling pathway
hsa04725Cholinergic synapse
hsa05031Amphetamine addiction
hsa05142Chagas disease (American trypanosomiasis)
hsa05323Rheumatoid arthritis
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa04728Dopaminergic synapse
hsa05168Herpes simplex infection
hsa05200Pathways in cancer
hsa05140Leishmaniasis
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa05210Colorectal cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031668cellular response to extracellular stimulusIEAbiological_process
GO:0003690double-stranded DNA bindingIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0008134transcription factor bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0030431sleepIEAbiological_process
GO:0034097response to cytokine stimulusIEAbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0007568agingIEAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0009416response to light stimulusIEAbiological_process
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0009409response to coldIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0009636response to toxinIEAbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0051412response to corticosterone stimulusIEAbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0032870cellular response to hormone stimulusIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0006306DNA methylationTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0071277cellular response to calcium ionIEAbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0008063Toll signaling pathwayTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007565female pregnancyIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0009629response to gravityIEAbiological_process
GO:0032570response to progesterone stimulusIEAbiological_process
GO:0001661conditioned taste aversionIEAbiological_process
GO:0007179transforming growth factor beta receptor signalingIDAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0070412R-SMAD bindingIPImolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0051591response to cAMPIEAbiological_process
GO:0007399nervous system developmentIEAbiological_process
GO:0051090regulation of sequence-specific DNA binding transcTASbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0060395SMAD protein signal transductionIDAbiological_process
GO:0034614cellular response to reactive oxygen speciesIDAbiological_process
GO:0006366transcription from RNA polymerase II promoterIEAbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0043005neuron projectionIEAcellular_component
GO:0006950response to stressIEAbiological_process