| UniProt/SwissProt ID: | HMGA1_HUMAN |
| Description: | high mobility group AT-hook 1 [Source:HGNC Symbol;Acc:5010] |
| Location: | chr6 p21.31 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S99 | EEEGIsQESSE | CSNK2A2 | HPRD |
| S99 | EEEGIsQESSE | CSNK2A1 | HPRD |
| S64 | GRPKGsKNKGA | PhosphoSitePlus | |
| T21 | QEKDGtEKRGR | PhosphoSitePlus | |
| S49 | SQKEPsEVPTP | PhosphoSitePlus; HPRD; RegPhos | |
| S103 | ISQESsEE | CSNK2A2 | HPRD |
| S103 | ISQESsEE | CSNK2A1 | HPRD |
| S103 | ISQESsEE | CK2_group | phosphoELM |
| S38 | PPKEPsEVPTP | HPRD | |
| T67 | RKTTTtPGRKP | CDK1 | HPRD |
| S99 | EEEGIsQESSE | CK2a2 | RegPhos |
| S44 | TALVGsQKEPS | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S92 | ISQESsEE | HPRD | |
| T42 | PSEVPtPKRPR | CDK1 | HPRD |
| S92 | ISQESsEE | CSNK2A1 | HPRD |
| S92 | ISQESsEE | CSNK2A2 | HPRD |
| S99 | EEEGIsQESSE | CK2a1 | RegPhos |
| S102 | GISQEsSEEEQ | PhosphoSitePlus; RegPhos | |
| T77 | TRKTTtTPGRK | PhosphoSitePlus | |
| S102 | GISQEsSEEEQ | CK_group(in isoform HMG-I | RegPhos |
| S103 | ISQESsEEEQ_ | PhosphoSitePlus | |
| T78 | RKTTTtPGRKP | CDK1 | HPRD; phosphoELM |
| T75 | AKTRKtTTTPG | PhosphoSitePlus | |
| S103 | ISQESsEE | HPRD; phosphoELM | |
| S91 | GISQEsSEE | HPRD | |
| S88 | EEEGIsQESSE | CSNK2A1 | HPRD |
| S88 | EEEGIsQESSE | CSNK2A2 | HPRD |
| S88 | EEEGIsQESSE | HPRD | |
| T78 | RKTTTtPGRKP | PhosphoSitePlus; phosphoELM | |
| S102 | GISQEsSEEEQ | CK2a2 | RegPhos |
| S102 | GISQEsSEEEQ | CK2a1 | RegPhos |
| T76 | KTRKTtTTPGR | PhosphoSitePlus | |
| S99 | EEEGIsQESSE | CK2a1-rs | RegPhos |
| S2 | ____MsESSSK | PhosphoSitePlus | |
| S99 | EEEGIsQESSE | CK2_group | phosphoELM; RegPhos |
| S103 | ISQESsEEEQ | CK2_group | RegPhos |
| S102 | GISQEsSEE | CK2_group | phosphoELM |
| T53 | PSEVPtPKRPR | CDC2 | RegPhos |
| T72 | KGAAKtRKTTT | PhosphoSitePlus | |
| S99 | EEEGIsQESSE | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S102 | GISQEsSEE | HPRD; phosphoELM | |
| S9 | SSSKSsQPLAS | PhosphoSitePlus | |
| T78 | RKTTTtPGRKP | CDC2 | RegPhos |
| T53 | PSEVPtPKRPR | PhosphoSitePlus; phosphoELM; RegPhos | |
| T53 | PSEVPtPKRPR | CDK1 | HPRD; phosphoELM |
| T53 | PSEVPtPKRPR | CDC2(CDK1 | RegPhos |
| S103 | ISQESsEEEQ | CK2a2 | RegPhos |
| S103 | ISQESsEEEQ | CK2a1 | RegPhos |
| S91 | GISQEsSEE | CSNK2A2 | HPRD |
| S102 | GISQEsSEE | CSNK2A2 | HPRD |
| S102 | GISQEsSEE | CSNK2A1 | HPRD |
| S103 | ISQESsEEEQ | RegPhos | |
| S103 | ISQESsEEEQ | CK2a1-rs | RegPhos |
| S91 | GISQEsSEE | CSNK2A1 | HPRD |
| T78 | RKTTTtPGRKP | CDC2(CDK1 | RegPhos |
| T39 | PVSPGtALVGS | PhosphoSitePlus; HPRD | |
| S102 | GISQEsSEEEQ | CK2a1-rs | RegPhos |
| S36 | KQPPVsPGTAL | PhosphoSitePlus; HPRD; RegPhos | |
| S102 | GISQEsSEEEQ | CK2_group | RegPhos |
| S103 | ISQESsEEEQ | CK_group(in isoform HMG-I | RegPhos |
| Dephosphorylation site |
| HMGA1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| HMGA1_HUMAN do not have mutation site. |
| Differential expressed protein |
| HMGA1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| HMGA1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK1_HUMAN | HMGA1_HUMAN | kinase -> substrate | RegPhos |
| CSK21_HUMAN | HMGA1_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | HMGA1_HUMAN | kinase -> substrate | RegPhos |
| CSK22_HUMAN | HMGA1_HUMAN | kinase -> substrate | HPRD |
| HMGA1_HUMAN | IBP1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| HMGA1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IMP | molecular_function |
| GO:0030374 | ligand-dependent nuclear receptor transcription co | IMP | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0042974 | retinoic acid receptor binding | IDA | molecular_function |
| GO:0035985 | senescence-associated heterochromatin focus | IDA | cellular_component |
| GO:0035986 | senescence-associated heterochromatin focus assemb | IDA | biological_process |
| GO:0006461 | protein complex assembly | TAS | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | TAS | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0046965 | retinoid X receptor binding | IDA | molecular_function |
| GO:0003680 | AT DNA binding | TAS | molecular_function |
| GO:0016032 | viral reproduction | TAS | biological_process |
| GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity | IDA | molecular_function |
| GO:0090402 | oncogene-induced senescence | IDA | biological_process |
| GO:0006284 | base-excision repair | IDA | biological_process |
| GO:0005667 | transcription factor complex | TAS | cellular_component |
| GO:0006337 | nucleosome disassembly | TAS | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IMP | biological_process |
| GO:0008285 | negative regulation of cell proliferation | IMP | biological_process |
| GO:0031936 | negative regulation of chromatin silencing | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006268 | DNA unwinding involved in replication | NAS | biological_process |
| GO:0042975 | peroxisome proliferator activated receptor binding | IDA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity | IDA | molecular_function |
| GO:0019899 | enzyme binding | IPI | molecular_function |
| GO:2000774 | positive regulation of cellular senescence | IMP | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IMP | biological_process |
| GO:0009615 | response to virus | IEP | biological_process |
| GO:0008134 | transcription factor binding | IDA | molecular_function |