Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GATA1_HUMAN
Description:GATA binding protein 1 (globin transcription factor 1) [Source:HGNC Symbol;Acc:4170]
Location:chrX p11.23
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y78PVFQVyPLLNCPhosphoSitePlus
Y285NACGLyYKLHQGATAPhosphoSitePlus
S310RNRKAsGKGKKPKB_groupphosphoELM
S310RNRKAsGKGKKPhosphoSitePlus
S310RNRKAsGKGKKAKT1HPRD; RegPhos
S178FSPTGsPLNSAPhosphoSitePlus
S187SAAYSsPKLRGHPRD
T324SSLGGtGAAEGPhosphoSitePlus
Y231NACGLyHKMNGArfGap; GATA; eIF-5_eIF-2PhosphoSitePlus
S310RNRKAsGKGKKAKT_groupRegPhos
S319KKKRGsSLGGTPhosphoSitePlus
S116PTREDsPPQAVPhosphoSitePlus; HPRD
Y223DRTGHyLCNACArfGap; GATA; eIF-5_eIF-2PhosphoSitePlus
S26PALVSsTPESGPhosphoSitePlus; HPRD
S142KTERLsPDLLTHPRD
S72EAYRHsPVFQVPhosphoSitePlus; HPRD
S91GIPGGsPYAGWPhosphoSitePlus
S320KKRGSsLGGTGPhosphoSitePlus

Dephosphorylation site
GATA1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000365858Q17*COSMICLymphoma12747884
ENSP00000365858E67*COSMICLymphoma15654280
ENSP00000365858E39*COSMICLymphoma19633202
ENSP00000365858Y69*COSMICLymphoma18830255
ENSP00000365858S30*Ding2008Neoplasms by Histologic Type12586620, 18428421, 18948947
ENSP00000365858Y63*COSMICLymphoma15180862
ENSP00000365858A61DCOSMICLymphoma19452320
ENSP00000365858E29*COSMICLymphoma15180862
ENSP00000365858S30*Ding2008Lung Cancer12586620, 18428421, 18948947
ENSP00000365858S47fs*90COSMICLymphoma12747884
ENSP00000365858S26FCOSMICLymphoma20418238
ENSP00000365858P50fs*87COSMICLymphoma12747884
ENSP00000365858Y62*COSMICLymphoma21287369
ENSP00000365858E2*COSMICLymphoma12649131
ENSP00000365858T11NCOSMICLymphoma12586620
ENSP00000365858M1ICOSMICLymphoma12649131
ENSP00000365858S30*COSMICLymphoma12586620
ENSP00000365858E13*COSMICLymphoma12649131
ENSP00000365858Q76EDing2008, COSMICLung Cancer18948947
ENSP00000365858V74ICOSMICLymphoma14656875
ENSP00000365858E2GCOSMICLymphoma19633202
ENSP00000365858A59VCOSMICLymphoma12586620

Differential expressed protein
GATA1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GATA1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANGATA1_HUMANkinase -> substrateHPRD; RegPhos
GATA1_HUMANHEM3_HUMANTF -> target geneTRANSFAC
GATA1_HUMANHBE_HUMANTF -> target geneTRANSFAC
GATA1_HUMANITA2B_HUMANTF -> target geneTRANSFAC
GATA1_HUMANGLPB_HUMANTF -> target geneTRANSFAC
GATA1_HUMANHBB_HUMANTF -> target geneTRANSFAC
GATA1_HUMANHBG1_HUMANTF -> target geneTRANSFAC
GATA1_HUMANGLPC_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
GATA1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001078RNA polymerase II core promoter proximal region seIDAmolecular_function
GO:0030099myeloid cell differentiationIEAbiological_process
GO:0043565sequence-specific DNA bindingIMPmolecular_function
GO:0048821erythrocyte developmentIMPbiological_process
GO:0005634nucleusIEAcellular_component
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0001158enhancer sequence-specific DNA bindingIEAmolecular_function
GO:0006366transcription from RNA polymerase II promoterIDAbiological_process
GO:0030219megakaryocyte differentiationIEAbiological_process
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIMPbiological_process
GO:0001077RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0003677DNA bindingIDAmolecular_function
GO:0003682chromatin bindingIEAmolecular_function
GO:0030222eosinophil differentiationIEPbiological_process
GO:0035162embryonic hemopoiesisIEAbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0030220platelet formationIEAbiological_process
GO:0000977RNA polymerase II regulatory region sequence-speciIDAmolecular_function
GO:0005667transcription factor complexIDAcellular_component
GO:0030221basophil differentiationIEPbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0048468cell developmentIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0030219megakaryocyte differentiationIMPbiological_process
GO:0030218erythrocyte differentiationIEPbiological_process
GO:0007267cell-cell signalingIEAbiological_process
GO:2000678negative regulation of transcription regulatory reIDAbiological_process
GO:0001085RNA polymerase II transcription factor bindingIPImolecular_function
GO:0000981sequence-specific DNA binding RNA polymerase II trIEAmolecular_function
GO:0030502negative regulation of bone mineralizationIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0071733transcriptional activation by promoter-enhancer loIEAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0000978RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0045648positive regulation of erythrocyte differentiationIMPbiological_process
GO:0043066negative regulation of apoptotic processTASbiological_process
GO:0070742C2H2 zinc finger domain bindingIPImolecular_function
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0008301DNA binding, bendingIEAmolecular_function
GO:0033690positive regulation of osteoblast proliferationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0097028dendritic cell differentiationIEAbiological_process
GO:0071733transcriptional activation by promoter-enhancer loISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0006366transcription from RNA polymerase II promoterIEAbiological_process
GO:0017053transcriptional repressor complexIDAcellular_component
GO:0000976transcription regulatory region sequence-specific IMPmolecular_function
GO:0097067cellular response to thyroid hormone stimulusIDAbiological_process
GO:0030218erythrocyte differentiationIEAbiological_process
GO:0031965nuclear membraneIDAcellular_component
GO:0002039p53 bindingIEAmolecular_function
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0070527platelet aggregationIMPbiological_process
GO:0010724regulation of definitive erythrocyte differentiatiIDAbiological_process
GO:0008584male gonad developmentIMPbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0030220platelet formationIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0035854eosinophil fate commitmentIDAbiological_process
GO:0010559regulation of glycoprotein biosynthetic processIMPbiological_process