Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TGFR2_HUMAN
Description:transforming growth factor, beta receptor II (70/80kDa) [Source:HGNC Symbol;Acc:11773]
Location:chr3 p24.1
Node attribute:PPI(target); PPI(source); substrate; kinase; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y336GNLQEyLTRHVTGFbR2phosphoELM; RegPhos
Y259RFAEVyKAKLKHPRD; RegPhos
S409LDPTLsVDDLATGFbR2phosphoELM; RegPhos
Y284FPYEEyASWKTPkinasePhosphoSitePlus
Y284RFAEVyKAKLKHPRD
Y424VGTARyMAPEVTGFbR2phosphoELM; RegPhos
Y284FPYEEyASWKTRegPhos
S416DDLANsGQVGTTGFbR2phosphoELM; RegPhos
S213KLMEFsEHCAIPhosphoSitePlus
S238KLMEFsEHCAITGFBR2HPRD
S551RLSGRsCSEEKHPRD; RegPhos
S416DDLANsGQVGTTGFBR2HPRD
S409LDPTLsVDDLAPkinasePhosphoSitePlus
Y361GNLQEyLTRHVHPRD
S225LEDDRsDISSTHPRD; RegPhos
S228DRSDIsSTCANHPRD; RegPhos
Y336GNLQEyLTRHVHPRD; RegPhos
S416DDLANsGQVGTPkinasePhosphoSitePlus
Y449VGTARyMAPEVHPRD
S409LDPTLsVDDLATGFBR2HPRD
S254RSDISsTCANNHPRD
S576RLSGRsCSEEKHPRD
S553SGRSCsEEKIPPhosphoSitePlus; HPRD; RegPhos
S250LEDDRsDISSTHPRD
Y336GNLQEyLTRHVPkinasePhosphoSitePlus
S587IPEDGsLNTHPRD
S441DDLANsGQVGTTGFBR2HPRD
Y424VGTARyMAPEVPkinasePhosphoSitePlus
S578SGRSCsEEKIPHPRD
S548HLDRLsGRSCSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S213KLMEFsEHCAITGFbR2phosphoELM; RegPhos
S434LDPTLsVDDLATGFBR2HPRD
S253DRSDIsSTCANHPRD
Y259RFAEVyKAKLKPkinasePhosphoSitePlus
Y259RFAEVyKAKLKTGFbR2phosphoELM; RegPhos
S229RSDISsTCANNHPRD; RegPhos
S441LENVEsFKQTDTGFbR2RegPhos
S562IPEDGsLNTTKPhosphoSitePlus; SysPTM
S562IPEDGsLNTHPRD; SysPTM
S573HLDRLsGRSCSHPRD
Y424VGTARyMAPEVHPRD; RegPhos
S213KLMEFsEHCAITGFBR2HPRD

Dephosphorylation site
TGFR2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000295754R528HBIOMART, OMIMColorectal Cancer21930507, 21930502, 15731757 9927040
ENSP00000295754N490SGreenman2007, HPIGastric Cancer17344846, 18428421
ENSP00000295754R497*Greenman2007Gastric Cancer17344846, 18428421
ENSP00000295754R497*Greenman2007Intestines Cancer17344846, 18428421
ENSP00000295754C393FBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000295754R528HSjoblom2006Intestines Cancer15731757, 16959974
ENSP00000295754W455SBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000295754E526QOMIM, HPIEsophageal Cancer10789724, 10789724 18339844
ENSP00000351905R504QTCGAOvarian Cancer21720365, 18772890
ENSP00000295754D524YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000295754C61RGreenman2007, HPIGastric Cancer17344846, 18428421
ENSP00000295754V447AHPIBreast Cancer11212236
ENSP00000295754R495*Greenman2007Intestines Cancer17344846, 18428421
ENSP00000295754N435SHPIBreast Cancer11212236
ENSP00000351905R520*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000351905T543SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000351905K493QTCGAOvarian Cancer21720365, 18772890
ENSP00000351905K287NTCGAOvarian Cancer21720365, 18772890
ENSP00000295754I73VBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000295754H328YGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000351905D471VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000295754I73VSjoblom2006Intestines Cancer16959974, 21930507, 21930502
ENSP00000295754T315MOMIM, HPIColorectal Cancer9590282, 9590282 17344846 20144264
ENSP00000295754D446VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000351905I120LTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000295754L452MHPIBreast Cancer11212236
ENSP00000295754R495*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000295754V387MHPIBreast Cancer11212236 17344846
ENSP00000351905W480SBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000295754W521*BIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
TGFR2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TGFR2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TGFR2_HUMAN2A5D_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANNRIP2_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANSUMO4_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANKS6A2_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANHSF1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANRGCC_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANUBE2A_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANPHLA2_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANASCC1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANFHL2_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANTGFR2_HUMANkinase -> substrateHPRD
TGFR2_HUMANPRDM1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANBMX_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANANS1A_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANCSDC2_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANPKNX1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANAKT3_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANZN363_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANSMC3_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANASCC3_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANSRA1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANRUVB2_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANRD23B_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANTGFR2_HUMANkinase -> substrateRegPhos
TGFR2_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANERF1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANSYSC_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANAIRE_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANFHL1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANRUVB1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANSAFB2_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANCRY1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANRAB14_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANANM8_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANTGFR1_HUMANkinase -> substrateHPRD
TGFR2_HUMANGPBP1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANHSP72_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANPRS6A_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANSPN1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANKCRM_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANSMAD7_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANMPIP1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANPSPC1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANNANO1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANCND3_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANUB2V2_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANTTF2_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANRHOA_HUMANotherKEGG
TGFR2_HUMANPP2AA_HUMANotherKEGG
TGFB1_HUMANTGFR2_HUMANotherKEGG
NFYB_HUMANTGFR2_HUMANTF -> target geneTRANSFAC
NFYA_HUMANTGFR2_HUMANTF -> target geneTRANSFAC
SP3_HUMANTGFR2_HUMANTF -> target geneTRANSFAC
EGR1_HUMANTGFR2_HUMANTF -> target geneTRANSFAC
SP1_HUMANTGFR2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04144Endocytosis
hsa05202Transcriptional misregulation in cancer
hsa05212Pancreatic cancer
hsa05142Chagas disease (American trypanosomiasis)
hsa05200Pathways in cancer
hsa05166HTLV-I infection
hsa04350TGF-beta signaling pathway
hsa05210Colorectal cancer
hsa04520Adherens junction
hsa04380Osteoclast differentiation
hsa05220Chronic myeloid leukemia
hsa04010MAPK signaling pathway
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051138positive regulation of NK T cell differentiationIEAbiological_process
GO:0031435mitogen-activated protein kinase kinase kinase binIEAmolecular_function
GO:2000379positive regulation of reactive oxygen species metIMPbiological_process
GO:0001569patterning of blood vesselsIEAbiological_process
GO:0042127regulation of cell proliferationISSbiological_process
GO:0007568agingIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0002663positive regulation of B cell tolerance inductionISSbiological_process
GO:0060439trachea morphogenesisIEAbiological_process
GO:0005901caveolaIDAcellular_component
GO:0002053positive regulation of mesenchymal cell proliferatIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0009897external side of plasma membraneIEAcellular_component
GO:0002651positive regulation of tolerance induction to selfISSbiological_process
GO:0010033response to organic substanceIEAbiological_process
GO:0005026transforming growth factor beta receptor activity,IEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0008284positive regulation of cell proliferationTASbiological_process
GO:0042493response to drugIDAbiological_process
GO:0051216cartilage developmentIEAbiological_process
GO:0005024transforming growth factor beta-activated receptorICmolecular_function
GO:0060021palate developmentISSbiological_process
GO:0060389pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0060443mammary gland morphogenesisIEAbiological_process
GO:0043235receptor complexIDAcellular_component
GO:0070022transforming growth factor beta receptor homodimerICcellular_component
GO:0042060wound healingIEAbiological_process
GO:0007369gastrulationIEAbiological_process
GO:0060021palate developmentIEAbiological_process
GO:0043627response to estrogen stimulusIEAbiological_process
GO:0060425lung morphogenesisIEAbiological_process
GO:0070723response to cholesterolIDAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0034713type I transforming growth factor beta receptor biIPImolecular_function
GO:0007182common-partner SMAD protein phosphorylationIEAbiological_process
GO:0002053positive regulation of mesenchymal cell proliferatISSbiological_process
GO:0009790embryo developmentIEAbiological_process
GO:0048565digestive tract developmentIEAbiological_process
GO:0002651positive regulation of tolerance induction to selfIEAbiological_process
GO:0034714type III transforming growth factor beta receptor IDAmolecular_function
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0001568blood vessel developmentTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0002666positive regulation of T cell tolerance inductionISSbiological_process
GO:0060044negative regulation of cardiac muscle cell prolifeIEAbiological_process
GO:0060433bronchus developmentIEAbiological_process
GO:0002088lens development in camera-type eyeIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0006898receptor-mediated endocytosisIEAbiological_process
GO:0018107peptidyl-threonine phosphorylationIDAbiological_process
GO:0043011myeloid dendritic cell differentiationIEAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0046332SMAD bindingIEAmolecular_function
GO:0048701embryonic cranial skeleton morphogenesisIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0032147activation of protein kinase activityIEAbiological_process
GO:0005901caveolaIEAcellular_component
GO:0031100organ regenerationIEAbiological_process
GO:0009897external side of plasma membraneIDAcellular_component
GO:0005539glycosaminoglycan bindingIDAmolecular_function
GO:0035162embryonic hemopoiesisIEAbiological_process
GO:0060463lung lobe morphogenesisIEAbiological_process
GO:0016021integral to membraneIDAcellular_component
GO:0001569patterning of blood vesselsISSbiological_process
GO:0007179transforming growth factor beta receptor signalingICbiological_process
GO:0007420brain developmentIEAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0051138positive regulation of NK T cell differentiationISSbiological_process
GO:0001570vasculogenesisIEAbiological_process
GO:0048545response to steroid hormone stimulusIEAbiological_process
GO:0043415positive regulation of skeletal muscle tissue regeIEAbiological_process
GO:0007420brain developmentISSbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0048661positive regulation of smooth muscle cell proliferIEAbiological_process
GO:0050431transforming growth factor beta bindingIPImolecular_function
GO:0043011myeloid dendritic cell differentiationISSbiological_process
GO:0030512negative regulation of transforming growth factor TASbiological_process
GO:0060440trachea formationIEAbiological_process
GO:0009887organ morphogenesisIEAbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0005887integral to plasma membraneIEAcellular_component
GO:0001570vasculogenesisISSbiological_process
GO:0002663positive regulation of B cell tolerance inductionIEAbiological_process
GO:0004702receptor signaling protein serine/threonine kinaseIEAmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0002666positive regulation of T cell tolerance inductionIEAbiological_process
GO:0070723response to cholesterolIEAbiological_process
GO:0035162embryonic hemopoiesisISSbiological_process
GO:0005024transforming growth factor beta-activated receptorIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0032147activation of protein kinase activityISSbiological_process
GO:0046332SMAD bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0004872receptor activityIEAmolecular_function
GO:0007224smoothened signaling pathwayIEAbiological_process
GO:0048701embryonic cranial skeleton morphogenesisISSbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0007584response to nutrientIEAbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0050431transforming growth factor beta bindingIEAmolecular_function
GO:0004675transmembrane receptor protein serine/threonine kiIDAmolecular_function
GO:0007566embryo implantationIEAbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0007507heart developmentISSbiological_process
GO:0060434bronchus morphogenesisIEAbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0010634positive regulation of epithelial cell migrationIEAbiological_process