Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CEBPA_HUMAN
Description:CCAAT/enhancer binding protein (C/EBP), alpha [Source:HGNC Symbol;Acc:1833]
Location:chr19 q13.11
Node attribute:gene; substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S21SSHLQsPPHAPErk2(MAPK1RegPhos
S332RVEQLsRELDTIBB; DUF2514; bZIP_2; NupPhosphoSitePlus
T226QPGHPtPPPTPGSK3BHPRD; RegPhos
S234PTPVPsPHPAPPhosphoSitePlus; HPRD; RegPhos
S21SSHLQsPPHAPErk1(MAPK3RegPhos
T230PTPPPtPVPSPGSK3BHPRD; RegPhos
S21SSHLQsPPHAPPhosphoSitePlus
S21SSHLQsPPHAPMAPK1phosphoELM
S21SSHLQsPPHAPMAPK3phosphoELM

Dephosphorylation site
CEBPA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000427514G116DCOSMICLymphoma14726504
ENSP00000427514G36fs*124COSMICLymphoma15645492
ENSP00000427514A47fs*113COSMICLymphoma14726504
ENSP00000427514H84LCOSMICLymphoma11242107
ENSP00000427514G272fs*46COSMICLymphoma14726504
ENSP00000427514L335QCOSMICLymphoma15746035
ENSP00000427514P39SCOSMICLymphoma16453003
ENSP00000427514P45fs*115COSMICLymphoma14726504
ENSP00000427514Y67fs*93COSMICLymphoma15645492
ENSP00000427514G32fs*128COSMICLymphoma18768433
ENSP00000427514P180fs*138COSMICLymphoma16453003
ENSP00000427514P180HCOSMICLymphoma15746041
ENSP00000427514E59*COSMICLymphoma12351377
ENSP00000427514R300LCOSMICLymphoma19525338
ENSP00000427514L78fs*82COSMICLymphoma12351377
ENSP00000427514E50*COSMICLymphoma11242107
ENSP00000427514G96fs*64COSMICLymphoma12692518
ENSP00000427514R339PCOSMICLymphoma18768433
ENSP00000427514A40fs*120COSMICLymphoma19525338
ENSP00000427514G102SCOSMICLymphoma20970189
ENSP00000427514V119fs*41COSMICLymphoma19171880
ENSP00000427514G122ECOSMICLymphoma15756005
ENSP00000427514Q83*COSMICLymphoma19171880
ENSP00000427514H84LOMIMLeukemia11242107
ENSP00000427514E316KCOSMICLymphoma14616999
ENSP00000427514Q305*COSMICLymphoma15645492
ENSP00000427514L324QCOSMICLymphoma15756005
ENSP00000427514F82fs*78COSMICLymphoma11242107
ENSP00000427514V314MCOSMICLymphoma17671232
ENSP00000427514S16fs*144COSMICLymphoma19650672
ENSP00000427514E89fs*71COSMICLymphoma18752591
ENSP00000427514Y181fs*137COSMICLymphoma18182175
ENSP00000427514Y108*COSMICLymphoma17671232
ENSP00000427514P239ACOSMICLymphoma20421268
ENSP00000427514A93fs*67COSMICLymphoma14726504
ENSP00000427514E334*COSMICLymphoma14726504
ENSP00000427514Q83fs*77COSMICLymphoma15746035
ENSP00000427514Q221fs*97COSMICLymphoma19171880
ENSP00000427514A118fs*42COSMICLymphoma12351377
ENSP00000427514Q312*COSMICLymphoma15746041
ENSP00000427514I62fs*98COSMICLymphoma15746035
ENSP00000427514P70fs*90COSMICLymphoma12692518
ENSP00000427514S319fs*13COSMICLymphoma18729193
ENSP00000427514G54fs*106COSMICLymphoma19171880
ENSP00000427514R289PCOSMICLymphoma19171880
ENSP00000427514E57*COSMICLymphoma20421268
ENSP00000427514A152fs*8COSMICLymphoma15746035
ENSP00000427514G340SCOSMICLymphoma15746041
ENSP00000427514P14RCOSMICLymphoma20421268
ENSP00000427514A176VCOSMICLymphoma15746041
ENSP00000427514R343fs*17COSMICLymphoma18587575
ENSP00000427514P42fs*118COSMICLymphoma15746035
ENSP00000427514E2*COSMICLymphoma14726504
ENSP00000427514D107fs*53COSMICLymphoma16453003
ENSP00000427514P23fs*137COSMICLymphoma15746041
ENSP00000427514Q88*COSMICLymphoma18752591
ENSP00000427514Y285*COSMICLymphoma11830484
ENSP00000427514R286fs*32COSMICLymphoma15756005
ENSP00000427514S21RCOSMICLymphoma15746041
ENSP00000427514P204fs*114COSMICLymphoma18729193
ENSP00000427514A303PCOSMICLymphoma20970189
ENSP00000427514Y181*COSMICLymphoma15746041
ENSP00000427514Q311*COSMICLymphoma18752591
ENSP00000427514L175VCOSMICLymphoma15746041
ENSP00000427514Q20*COSMICLymphoma15618961
ENSP00000427514G117fs*43COSMICLymphoma18752591
ENSP00000427514R142TCOSMICLymphoma19171880
ENSP00000427514R297PCOSMICLymphoma18752591
ENSP00000427514E290*COSMICLymphoma11830484
ENSP00000427514R306PCOSMICLymphoma11830484
ENSP00000427514A295PCOSMICLymphoma19171880
ENSP00000427514T60fs*100COSMICLymphoma15756005
ENSP00000427514A44fs*116COSMICLymphoma15645492
ENSP00000427514R165fs*153COSMICLymphoma11242107
ENSP00000427514P235fs*83COSMICLymphoma18729193

Differential expressed protein
CEBPA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CEBPA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANCEBPA_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANCEBPA_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANCEBPA_HUMANkinase -> substrateRegPhos
MK03_HUMANCEBPA_HUMANkinase -> substrateRobert H Newman (2013)
CEBPA_HUMANFA9_HUMANTF -> target geneTRANSFAC
CEBPA_HUMANCETP_HUMANTF -> target geneTRANSFAC
CEBPA_HUMANTRFE_HUMANTF -> target geneTRANSFAC
CEBPA_HUMANFIBA_HUMANTF -> target geneTRANSFAC
CEBPA_HUMANANT3_HUMANTF -> target geneTRANSFAC
CEBPA_HUMANPPARG_HUMANTF -> target geneTRANSFAC
CEBPA_HUMANICAM1_HUMANTF -> target geneTRANSFAC
CEBPA_HUMANAPOA2_HUMANTF -> target geneTRANSFAC
CEBPA_HUMANCRP_HUMANTF -> target geneTRANSFAC
USF1_HUMANCEBPA_HUMANTF -> target geneTRANSFAC
CEBPA_HUMANIL10_HUMANTF -> target geneTRANSFAC
CEBPA_HUMANAPOB_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05221Acute myeloid leukemia
hsa05200Pathways in cancer
hsa05202Transcriptional misregulation in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006351transcription, DNA-dependentIDAbiological_process
GO:0071837HMG box domain bindingIEAmolecular_function
GO:0048839inner ear developmentIEAbiological_process
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0001889liver developmentIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0005634nucleusNAScellular_component
GO:0003705RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specifiNASmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0000050urea cycleIEAbiological_process
GO:0008203cholesterol metabolic processIEAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0071407cellular response to organic cyclic compoundIEAbiological_process
GO:0016363nuclear matrixIEAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0050872white fat cell differentiationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0003677DNA bindingTASmolecular_function
GO:0019221cytokine-mediated signaling pathwayNASbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0030099myeloid cell differentiationIEAbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0030225macrophage differentiationIEAbiological_process
GO:0035189Rb-E2F complexIEAcellular_component
GO:0045669positive regulation of osteoblast differentiationIEAbiological_process
GO:0071285cellular response to lithium ionIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0045600positive regulation of fat cell differentiationIEAbiological_process
GO:0001892embryonic placenta developmentIEAbiological_process
GO:0006091generation of precursor metabolites and energyTASbiological_process
GO:0007584response to nutrientIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0050873brown fat cell differentiationIEAbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0007005mitochondrion organizationIEAbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0045444fat cell differentiationIEAbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0033274response to vitamin B2IEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030099myeloid cell differentiationNASbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0045945positive regulation of transcription from RNA polyIDAbiological_process
GO:0048469cell maturationIEAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0006953acute-phase responseIEAbiological_process
GO:0031100organ regenerationIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process