Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TF7L2_HUMAN
Description:transcription factor 7-like 2 (T-cell specific, HMG-box) [Source:HGNC Symbol;Acc:11641]
Location:chr10 q25.2
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T201HVHPLtPLITYCTNNB1_bindingPhosphoSitePlus
Y151QIAVQyLQMKWCTNNB1_bindingPhosphoSitePlus
S58ETNQNsSSDSECK2a1RegPhos
S60NQNSSsDSEAECSNK2A2HPRD
S60NQNSSsDSEAECSNK2A1HPRD
S59TNQNSsSDSEACK2a1RegPhos
S59TNQNSsSDSEACK2a2RegPhos
S58ETNQNsSSDSECK2_groupphosphoELM; RegPhos
S58ETNQNsSSDSECSNK2A2HPRD
S58ETNQNsSSDSECK2a1-rsRegPhos
S60NQNSSsDSEAECK2a1RegPhos
S179DARSPsPAHIVCTNNB1_bindingPhosphoSitePlus
Y414LHMQLyPGWSAHMG_boxPhosphoSitePlus
S58ETNQNsSSDSECSNK2A1HPRD
S177LKDARsPSPAHCTNNB1_bindingPhosphoSitePlus
S60NQNSSsDSEAECK2a2RegPhos
S59TNQNSsSDSEACK2_groupphosphoELM; RegPhos
Y400EQAKYyELARKHMG_boxPhosphoSitePlus
Y489KKCVRyIQGEGPhosphoSitePlus
S79SFRDKsRESLECTNNB1_bindingPhosphoSitePlus
Y399EEQAKyYELARHMG_boxPhosphoSitePlus
S60NQNSSsDSEAECK2_groupphosphoELM; RegPhos
S58ETNQNsSSDSECK2a2RegPhos
S60NQNSSsDSEAECK2a1-rsRegPhos
S59TNQNSsSDSEACK2a1-rsRegPhos
S82DKSREsLEEAACTNNB1_bindingPhosphoSitePlus
S324VKQESsQSDVGPhosphoSitePlus
T212SNEHFtPGNPPCTNNB1_bindingPhosphoSitePlus
S59TNQNSsSDSEACSNK2A1HPRD
S59TNQNSsSDSEACSNK2A2HPRD

Dephosphorylation site
TF7L2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358404R465CSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000440547*620YCOSMICIntestines Cancer16959974
ENSP00000348274*620YCOSMICIntestines Cancer16959974
ENSP00000358404P258TCOSMICOvarian Cancer21720365
ENSP00000444972P254TTCGAOvarian Cancer21720365, 18772890
ENSP00000444972P281TTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
TF7L2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TF7L2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GSK3A_HUMANTF7L2_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANTF7L2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK22_HUMANTF7L2_HUMANkinase -> substrateHPRD
NLK_HUMANTF7L2_HUMANkinase -> substrateNetPath
TF7L2_HUMANCCND1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04310Wnt signaling pathway
hsa05200Pathways in cancer
hsa05215Prostate cancer
hsa05217Basal cell carcinoma
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A
hsa04916Melanogenesis
hsa05221Acute myeloid leukemia
hsa04520Adherens junction
hsa05216Thyroid cancer
hsa05213Endometrial cancer
hsa05210Colorectal cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003682chromatin bindingIBAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0016605PML bodyIEAcellular_component
GO:0042593glucose homeostasisIDAbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0032252secretory granule localizationIEAbiological_process
GO:0014003oligodendrocyte developmentIEAbiological_process
GO:0000978RNA polymerase II core promoter proximal region seIDAmolecular_function
GO:0060070canonical Wnt receptor signaling pathwayIEAbiological_process
GO:0008013beta-catenin bindingIEAmolecular_function
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0044334canonical Wnt receptor signaling pathway involved IMPbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0031016pancreas developmentTASbiological_process
GO:0046621negative regulation of organ growthIEAbiological_process
GO:0035411catenin import into nucleusIEAbiological_process
GO:0040037negative regulation of fibroblast growth factor reIEAbiological_process
GO:0048625myoblast cell fate commitmentIEAbiological_process
GO:0043570maintenance of DNA repeat elementsIMPbiological_process
GO:0090090negative regulation of canonical Wnt receptor signIMPbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0007050cell cycle arrestIMPbiological_process
GO:0032024positive regulation of insulin secretionIDAbiological_process
GO:0048641regulation of skeletal muscle tissue developmentIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0000790nuclear chromatinIDAcellular_component
GO:0030282bone mineralizationIEAbiological_process
GO:0022008neurogenesisIBAbiological_process
GO:0048625myoblast cell fate commitmentIDAbiological_process
GO:0061178regulation of insulin secretion involved in cellulIEAbiological_process
GO:0008283cell proliferationIMPbiological_process
GO:0060070canonical Wnt receptor signaling pathwayICbiological_process
GO:0051897positive regulation of protein kinase B signaling IMPbiological_process
GO:0032993protein-DNA complexIDAcellular_component
GO:0021983pituitary gland developmentIEAbiological_process
GO:0048699generation of neuronsIBAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0008134transcription factor bindingIPImolecular_function
GO:0030514negative regulation of BMP signaling pathwayIEAbiological_process
GO:0046827positive regulation of protein export from nucleusIMPbiological_process
GO:0031641regulation of myelinationIEAbiological_process
GO:0048660regulation of smooth muscle cell proliferationIMPbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0010909positive regulation of heparan sulfate proteoglycaIMPbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0001103RNA polymerase II repressing transcription factor IPImolecular_function
GO:0006357regulation of transcription from RNA polymerase IIIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0043588skin developmentIEAbiological_process
GO:0043565sequence-specific DNA bindingIDAmolecular_function
GO:0043433negative regulation of sequence-specific DNA bindiIDAbiological_process
GO:0035019somatic stem cell maintenanceIEAbiological_process
GO:0005667transcription factor complexIBAcellular_component
GO:0035257nuclear hormone receptor bindingIPImolecular_function
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0032350regulation of hormone metabolic processIDAbiological_process
GO:0048713regulation of oligodendrocyte differentiationIEAbiological_process
GO:0070369beta-catenin-TCF7L2 complexIDAcellular_component
GO:0009749response to glucose stimulusISSbiological_process
GO:0001568blood vessel developmentIMPbiological_process
GO:0045295gamma-catenin bindingIPImolecular_function
GO:0005634nucleusIDAcellular_component
GO:0048619embryonic hindgut morphogenesisIEAbiological_process
GO:0048557embryonic digestive tract morphogenesisIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0007420brain developmentIBAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0050679positive regulation of epithelial cell proliferatiIEAbiological_process
GO:0021915neural tube developmentIEAbiological_process
GO:0032092positive regulation of protein bindingIDAbiological_process
GO:0045444fat cell differentiationIDAbiological_process
GO:0045599negative regulation of fat cell differentiationIEAbiological_process
GO:0060325face morphogenesisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030538embryonic genitalia morphogenesisIEAbiological_process
GO:0008013beta-catenin bindingIPImolecular_function
GO:0070016armadillo repeat domain bindingIPImolecular_function
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0005654nucleoplasmIDAcellular_component
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process