Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HSF1_HUMAN
Description:heat shock transcription factor 1 [Source:HGNC Symbol;Acc:5224]
Location:chr8 q24.3
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S127VSTLKsEDIKIHPRD
S314RVEEAsPGRPSVert_HS_TFPhosphoSitePlus
S363EGRPPsPPPTSMAPK8HPRD; SysPTM
T367PSPPPtSTPEKVert_HS_TFPhosphoSitePlus
S326VDTLLsPTALIHPRD; phosphoELM; RegPhos
T142VTKLLtDVQLMphosphoELM
S419LLDLFsPSVTVphosphoELM; RegPhos
S283ASPGGsIDERPVert_HS_TFPhosphoSitePlus
S303KEEPPsPPQSPVert_HS_TFPhosphoSitePlus
T369PPPTStPEKCLHPRD; phosphoELM
T142VTKLLtDVQLMDUF247; DUF2365PhosphoSitePlus
S326VDTLLsPTALIVert_HS_TFPhosphoSitePlus
S121KRKVTsVSTLKHSF_DNA-bind; DUF247; DUFPhosphoSitePlus
S292RPLSSsPLVRVVert_HS_TFPhosphoSitePlus
S279ASPMAsPGGSIVert_HS_TFPhosphoSitePlus
S314RVEEAsPGRPSHPRD; phosphoELM; RegPhos
S444IQELLsPQEPPphosphoELM; RegPhos
S368SPPPTsTPEKCVert_HS_TFPhosphoSitePlus
S363EGRPPsPPPTSHPRD; phosphoELM; RegPhos; SysPTM
S307PSPPQsPRVEEErk1RegPhos
T142VTKLLtDVQLMCK2a1(CK2 alphaRegPhos
S363EGRPPsPPPTSVert_HS_TFPhosphoSitePlus; SysPTM
S230YSRQFsLEHVHCaMK2aRegPhos
S307PSPPQsPRVEEMAPK_groupphosphoELM; RegPhos
S444IQELLsPQEPPVert_HS_TFPhosphoSitePlus
T355DARGHtDTEGRVert_HS_TFPhosphoSitePlus
T142VTKLLtDVQLMCK2_alphaphosphoELM
T142VTKLLtDVQLMCK2_groupphosphoELM; RegPhos
S344EPAPAsVTALTVert_HS_TFPhosphoSitePlus
T323PSSVDtLLSPTVert_HS_TFPhosphoSitePlus
S368SPPPTsTPEKCHPRD; phosphoELM
T142VTKLLtDVQLMCK2a1RegPhos
S230YSRQFsLEHVHCaM-KII_alphaphosphoELM
S307PSPPQsPRVEEVert_HS_TFPhosphoSitePlus
S127VSTLKsEDIKIDUF247; DUF2365PhosphoSitePlus
S319SPGRPsSVDTLVert_HS_TFPhosphoSitePlus
S121KRKVTsVSTLKMAPKAPK2phosphoELM; RegPhos
S275ELAPAsPMASPVert_HS_TFPhosphoSitePlus
S121KRKVTsVSTLKHPRD
S303KEEPPsPPQSPGSK-3_groupphosphoELM
T369PPPTStPEKCLVert_HS_TFPhosphoSitePlus
S230YSRQFsLEHVHPhosphoSitePlus; phosphoELM
S303KEEPPsPPQSPGSK_groupRegPhos
S363EGRPPsPPPTSJNK1RegPhos; SysPTM
S320PGRPSsVDTLLVert_HS_TFPhosphoSitePlus
S320PGRPSsVDTLLHPRD
T323PSSVDtLLSPTHPRD; phosphoELM; RegPhos
S292RPLSSsPLVRVHPRD; phosphoELM; RegPhos
S501EGSYFsEGDGFVert_HS_TFPhosphoSitePlus
S307PSPPQsPRVEEHPRD; phosphoELM; RegPhos
S303KEEPPsPPQSPGSK3AHPRD; RegPhos
S344EPAPAsVTALTphosphoELM; RegPhos
T357RGHTDtEGRPPVert_HS_TFPhosphoSitePlus
S303KEEPPsPPQSPHPRD; phosphoELM; RegPhos
S319SPGRPsSVDTLHPRD; phosphoELM; RegPhos
S363EGRPPsPPPTSJNK_groupphosphoELM; RegPhos; SysPTM
S307PSPPQsPRVEEMAPK3HPRD
S230YSRQFsLEHVHCAMK2AHPRD
T142VTKLLtDVQLMCSNK2A1HPRD
T142VTKLLtDVQLMCK2a1-rsRegPhos
S419LLDLFsPSVTVVert_HS_TFPhosphoSitePlus
S230YSRQFsLEHVHCaMK2_groupRegPhos
S216LMLNDsGSAHSPhosphoSitePlus
T367PSPPPtSTPEKHPRD; phosphoELM
S230YSRQFsLEHVHCaM-KII_groupphosphoELM

Dephosphorylation site
HSF1_HUMAN do not have dephosphorylation site.

Mutation site
HSF1_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000431512Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.515169874

Hyperphosphorylation site
HSF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KS6B1_HUMANHSF1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANHSF1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK2_HUMANHSF1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANHSF1_HUMANkinase -> substrateRegPhos
KCC4_HUMANHSF1_HUMANkinase -> substrateRobert H Newman (2013)
GSK3A_HUMANHSF1_HUMANkinase -> substrateHPRD; RegPhos
KCC2D_HUMANHSF1_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANHSF1_HUMANkinase -> substrateHPRD
MP2K2_HUMANHSF1_HUMANkinase -> substrateRobert H Newman (2013)
DYRK2_HUMANHSF1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANHSF1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
KCC2A_HUMANHSF1_HUMANkinase -> substrateHPRD
NEK6_HUMANHSF1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANHSF1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
HSF1_HUMANHSP71_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05134Legionellosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIDAcellular_component
GO:0007283spermatogenesisIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0009408response to heatIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0032720negative regulation of tumor necrosis factor produIEAbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0001162RNA polymerase II intronic transcription regulatorIDAmolecular_function
GO:0040018positive regulation of multicellular organism growIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0034605cellular response to heatIDAbiological_process
GO:0001892embryonic placenta developmentIEAbiological_process
GO:0045120pronucleusIEAcellular_component
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0060136embryonic process involved in female pregnancyIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0043234protein complexIEAcellular_component
GO:0090231regulation of spindle checkpointIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0007143female meiosisIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process


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