Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GABPA_HUMAN
Description:GA binding protein transcription factor, alpha subunit 60kDa [Source:HGNC Symbol;Acc:4071]
Location:chr21 q21.3
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S218TTLNIsGRELCSAM_PNTPhosphoSitePlus
S303RAPRIsGEDRSPhosphoSitePlus; HPRD
Y382ALRYYyDGDMIEtsPhosphoSitePlus
Y381RALRYyYDGDMEtsPhosphoSitePlus
Y380SRALRyYYDGDEtsPhosphoSitePlus

Dephosphorylation site
GABPA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000382948L81SCOSMICOvarian Cancer21720365
ENSP00000346886I42MBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000346886S303LBIOMARTBreast Cancer21930507, 21930502
ENSP00000382948P353LBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000346886R165TCOSMICSkin Cancer21984974
ENSP00000382948Q97PCOSMICOvarian Cancer21720365
ENSP00000346886Q97PTCGAOvarian Cancer21720365, 18772890
ENSP00000346886L81SCOSMICOvarian Cancer21720365
ENSP00000382948R165TCOSMICSkin Cancer21984974
ENSP00000382948Q97PTCGAOvarian Cancer21720365, 18772890
ENSP00000346886P353LBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000346886Q97PCOSMICOvarian Cancer21720365
ENSP00000382948S303LBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
GABPA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GABPA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KS6A2_HUMANGABPA_HUMANkinase -> substrateRobert H Newman (2013)
GABPA_HUMANIL2RB_HUMANTF -> target geneTRANSFAC
GABPA_HUMANTFAM_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
GABPA_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046982protein heterodimerization activityIDAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0000790nuclear chromatinIDAcellular_component
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0001228RNA polymerase II transcription regulatory region IDAmolecular_function
GO:0000978RNA polymerase II core promoter proximal region seIDAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0003713transcription coactivator activityTASmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0043565sequence-specific DNA bindingIEAmolecular_function


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