Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PTPRC_HUMAN
Description:protein tyrosine phosphatase, receptor type, C [Source:HGNC Symbol;Acc:9666]
Location:chr1 q31.3
Node attribute:substrate; phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1003DSDESsDDDSDCK2_alphaphosphoELM
S999ESEHDsDESSDCK2_groupphosphoELM
S278ECKNAsVSISHCD45PhosphoSitePlus
Y880NKVDVyGYVVKY_phosphatasePhosphoSitePlus
Y681QNKNRyVDILPY_phosphatasePhosphoSitePlus
S1291EGPEHsVNGPAPhosphoSitePlus
S1003DSDESsDDDSDCK2_groupphosphoELM
S1002HDSDEsSDDDSCK2_alphaphosphoELM
Y926SELHPyLHNMKPhosphoSitePlus
S1007SSDDDsDSEEPCK2_alphaphosphoELM
T858AGVGRtGTYIGY_phosphatasePhosphoSitePlus
S995EMSKEsEHDSDY_phosphatasePhosphoSitePlus
S1002HDSDEsSDDDSCK2_groupphosphoELM
T860VGRTGtYIGIDY_phosphatasePhosphoSitePlus
Y559FHNGDyPGEPFfn3PhosphoSitePlus
Y689ILPYDyNRVELY_phosphatasePhosphoSitePlus
S999ESEHDsDESSDCK2_alphaphosphoELM
S1007SSDDDsDSEEPPKC_groupphosphoELM
S456TKYVLsLHAYIfn3PhosphoSitePlus
Y548QYSTDyTFKAYfn3PhosphoSitePlus
Y861GRTGTyIGIDAY_phosphatasePhosphoSitePlus
Y453KPYTKyVLSLHfn3PhosphoSitePlus
S951FQRLPsYRSWRPhosphoSitePlus
S1297VNGPAsPALNQPhosphoSitePlus
Y763NKCAEyWPSMEY_phosphatasePhosphoSitePlus
Y1216STFEQyQFLYDCskphosphoELM
Y1216STFEQyQFLYDY_phosphatasePhosphoSitePlus
Y978SNVIPyDYNRVY_phosphatasePhosphoSitePlus
Y900QVEAQyILIHQY_phosphatasePhosphoSitePlus
Y687VDILPyDYNRVY_phosphatasePhosphoSitePlus
Y1220QYQFLyDVIASY_phosphatasePhosphoSitePlus
S992HELEMsKESEHY_phosphatasePhosphoSitePlus
S995EMSKEsEHDSDphosphoELM
T1285EPTSGtEGPEHPhosphoSitePlus
S1279EQAEGsEPTSGPhosphoSitePlus
S1007SSDDDsDSEEPY_phosphatasePhosphoSitePlus
S1003DSDESsDDDSDY_phosphatasePhosphoSitePlus
S973SKNRNsNVIPYY_phosphatasePhosphoSitePlus
Y705DAGSNyINASYY_phosphatasePhosphoSitePlus
Y710YINASyIDGFKY_phosphatasePhosphoSitePlus
Y790KRCPDyIIQKLY_phosphatasePhosphoSitePlus
Y544VKDLQySTDYTfn3PhosphoSitePlus
S657LAEFQsIPRVFPhosphoSitePlus
Y980VIPYDyNRVPLY_phosphatasePhosphoSitePlus

Dephosphorylation site
PTPRC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000411355G23RCOSMICRenal Cancer20054297
ENSP00000411355S92RCOSMICPancreatic Cancer21252315
ENSP00000411355A582VCOSMICOvarian Cancer21720365
ENSP00000411355A582VTCGAOvarian Cancer21720365, 18772890
ENSP00000411355A129TCOSMICSkin Cancer21984974
ENSP00000306782R354HBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000411355E200KCOSMICMelanoma
ENSP00000411355Q656*COSMICMelanoma19074898
ENSP00000411355P160QTCGAOvarian Cancer21720365, 18772890
ENSP00000411355R757WBIOMARTBreast Cancer21930507, 21930502
ENSP00000411355G863RCOSMICBreast Cancer16959974
ENSP00000411355T1282MCOSMICSkin Cancer21984974
ENSP00000411355E228KCOSMICMelanoma
ENSP00000411355P160QCOSMICOvarian Cancer21720365
ENSP00000411355R515HBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000411355T72SCOSMICBreast Cancer
ENSP00000411355R660QCOSMICHead and Neck Cancer21798893
ENSP00000411355P563LCOSMICMelanoma19074898
ENSP00000411355S1151FCOSMICMelanoma19074898
ENSP00000411355D621NCOSMICMelanoma21499247
ENSP00000411355G1232RCOSMICHead and Neck Cancer21984974
ENSP00000411355A944TCOSMICSkin Cancer21984974
ENSP00000411355E1134KCOSMICMelanoma19074898
ENSP00000411355Q895*COSMICMelanoma19074898
ENSP00000306782R596WBIOMARTBreast Cancer21930507, 21930502
ENSP00000411355E228ABIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
PTPRC_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PTPRC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK22_HUMANPTPRC_HUMANkinase -> substrateHPRD
CSK21_HUMANPTPRC_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK_HUMANPTPRC_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANPTPRC_HUMANkinase -> substrateRegPhos
PTPRC_HUMANFYN_HUMANphosphatase -> substrateHPRD; KEGG
PTPRC_HUMANEZRI_HUMANphosphatase -> substrateHPRD
PTPRC_HUMANJAK2_HUMANphosphatase -> substrateHPRD
PTPRC_HUMANLYN_HUMANphosphatase -> substrateHPRD
PTPRC_HUMANJAK1_HUMANphosphatase -> substrateHPRD
PTPRC_HUMANTYK2_HUMANphosphatase -> substrateHPRD
PTPRC_HUMANINSR_HUMANphosphatase -> substrateHPRD
PTPRC_HUMANSKAP1_HUMANphosphatase -> substrateHPRD
PTPRC_HUMANLCK_HUMANphosphatase -> substrateHPRD; KEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05340Primary immunodeficiency
hsa04514Cell adhesion molecules (CAMs)
hsa04660T cell receptor signaling pathway
hsa04666Fc gamma R-mediated phagocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050853B cell receptor signaling pathwayIEAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0030890positive regulation of B cell proliferationIMPbiological_process
GO:0050732negative regulation of peptidyl-tyrosine phosphoryIEAbiological_process
GO:0051209release of sequestered calcium ion into cytosolISSbiological_process
GO:0042102positive regulation of T cell proliferationIEAbiological_process
GO:2000648positive regulation of stem cell proliferationIMPbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0030890positive regulation of B cell proliferationIEAbiological_process
GO:0051607defense response to virusIEAbiological_process
GO:0043395heparan sulfate proteoglycan bindingIEAmolecular_function
GO:0050853B cell receptor signaling pathwayISSbiological_process
GO:0002244hematopoietic progenitor cell differentiationIMPbiological_process
GO:0001915negative regulation of T cell mediated cytotoxicitIEAbiological_process
GO:0031953negative regulation of protein autophosphorylationIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0030217T cell differentiationISSbiological_process
GO:0048304positive regulation of isotype switching to IgG isIEAbiological_process
GO:0042100B cell proliferationIEAbiological_process
GO:0016791phosphatase activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:2000473positive regulation of hematopoietic stem cell migIMPbiological_process
GO:0045060negative thymic T cell selectionIEAbiological_process
GO:0002711positive regulation of T cell mediated immunityIEAbiological_process
GO:0016311dephosphorylationISSbiological_process
GO:0000187activation of MAPK activityIEAbiological_process
GO:0001960negative regulation of cytokine-mediated signalingISSbiological_process
GO:0050855regulation of B cell receptor signaling pathwayIEAbiological_process
GO:0005887integral to plasma membraneIEAcellular_component
GO:0030183B cell differentiationIEAbiological_process
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0050857positive regulation of antigen receptor-mediated sISSbiological_process
GO:0045860positive regulation of protein kinase activityNASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0035335peptidyl-tyrosine dephosphorylationIDAbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0042102positive regulation of T cell proliferationISSbiological_process
GO:0045582positive regulation of T cell differentiationIEAbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0048539bone marrow developmentIMPbiological_process
GO:0051209release of sequestered calcium ion into cytosolIEAbiological_process
GO:0051726regulation of cell cycleIEAbiological_process
GO:0030217T cell differentiationIEAbiological_process
GO:0005887integral to plasma membraneISScellular_component
GO:0045059positive thymic T cell selectionIEAbiological_process
GO:0010332response to gamma radiationIEAbiological_process
GO:0002378immunoglobulin biosynthetic processIMPbiological_process
GO:0050852T cell receptor signaling pathwayIEAbiological_process
GO:0004725protein tyrosine phosphatase activityIEAmolecular_function
GO:0006469negative regulation of protein kinase activityISSbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005925focal adhesionISScellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0001915negative regulation of T cell mediated cytotoxicitISSbiological_process
GO:0007159leukocyte cell-cell adhesionIEAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0002923regulation of humoral immune response mediated by IEAbiological_process
GO:0001960negative regulation of cytokine-mediated signalingIEAbiological_process
GO:0050857positive regulation of antigen receptor-mediated sIEAbiological_process
GO:0042098T cell proliferationIEAbiological_process
GO:0001916positive regulation of T cell mediated cytotoxicitIEAbiological_process
GO:0034113heterotypic cell-cell adhesionIEAbiological_process
GO:0043410positive regulation of MAPK cascadeIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0051607defense response to virusISSbiological_process
GO:0051726regulation of cell cycleISSbiological_process
GO:0002925positive regulation of humoral immune response medIEAbiological_process
GO:0006470protein dephosphorylationIEAbiological_process
GO:0005001transmembrane receptor protein tyrosine phosphatasTASmolecular_function
GO:0009897external side of plasma membraneIDAcellular_component
GO:0006933negative regulation of cell adhesion involved in sIMPbiological_process
GO:0048864stem cell developmentIMPbiological_process
GO:0042100B cell proliferationISSbiological_process
GO:0045588positive regulation of gamma-delta T cell differenIEAbiological_process
GO:0046641positive regulation of alpha-beta T cell proliferaIEAbiological_process
GO:0016311dephosphorylationIEAbiological_process
GO:0071944cell peripheryIEAcellular_component
GO:0005925focal adhesionIEAcellular_component
GO:0045577regulation of B cell differentiationIEAbiological_process
GO:0008201heparin bindingIEAmolecular_function
GO:0006470protein dephosphorylationISSbiological_process
GO:0033261regulation of S phaseIMPbiological_process