Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:E2F1_HUMAN
Description:E2F transcription factor 1 [Source:HGNC Symbol;Acc:3113]
Location:chr20 q11.22
Node attribute:gene; substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S403EFISLsPPHEAGTF2H1HPRD
S403EFISLsPPHEACDK7HPRD; phosphoELM; RegPhos
T433DFGDLtPLDF_PhosphoSitePlus
T433DFGDLtPLGTF2H1HPRD
T136SLNLTtKRFLETP1; E2F_TDPPhosphoSitePlus
S337SPPPSsPPSSLCDK1HPRD; phosphoELM
S332SATIVsPPPSSCDC2RegPhos
S332SATIVsPPPSSCDK1HPRD; phosphoELM
S332SATIVsPPPSSCDC2(CDK1RegPhos
S337SPPPSsPPSSLCDC2(CDK1RegPhos
T433DFGDLtPLDFCDK7RegPhos
S31RLLDSsQIVIIATMHPRD; phosphoELM; RegPhos
S31RLLDSsQIVIIATRHPRD; phosphoELM; RegPhos
S332SATIVsPPPSSPhosphoSitePlus
T433DFGDLtPLDFP32780(TFIIH 62 kDa subunRegPhos
S403EFISLsPPHEAPhosphoSitePlus
S337SPPPSsPPSSLPhosphoSitePlus
S364LSRMGsLRAPVCHK2phosphoELM; RegPhos
T135TSLNLtTKRFLTP1; E2F_TDPPhosphoSitePlus
S403EFISLsPPHEAP32780(TFIIH 62 kDa subunRegPhos
S337SPPPSsPPSSLCDC2RegPhos
S364LSRMGsLRAPVCHEK2HPRD
T433DFGDLtPLCDK7HPRD; phosphoELM
S375DEDRLsPLVAAPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S31RLLDSsQIVIIPhosphoSitePlus
S364LSRMGsLRAPVPhosphoSitePlus

Dephosphorylation site
E2F1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000345571R252CCOSMICHead and Neck Cancer21798893

Differential expressed protein
E2F1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
E2F1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK1_HUMANE2F1_HUMANkinase -> substrateRegPhos
ATR_HUMANE2F1_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANE2F1_HUMANkinase -> substrateRegPhos
TF2H1_HUMANE2F1_HUMANkinase -> substrateHPRD
KC1D_HUMANE2F1_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANE2F1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
ATM_HUMANE2F1_HUMANkinase -> substrateHPRD; RegPhos
CDK7_HUMANE2F1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
E2F1_HUMANCCND1_HUMANTF -> target geneTRANSFAC
E2F1_HUMANCCNE1_HUMANTF -> target geneTRANSFAC
E2F1_HUMANMPIP1_HUMANTF -> target geneTRANSFAC
NFYA_HUMANE2F1_HUMANTF -> target geneTRANSFAC
NR4A1_HUMANE2F1_HUMANTF -> target geneTRANSFAC
E2F1_HUMANE2F1_HUMANTF -> target geneTRANSFAC
E2F1_HUMANRB_HUMANTF -> target geneTRANSFAC
E2F1_HUMANH2A1_HUMANTF -> target geneTRANSFAC
SP3_HUMANE2F1_HUMANTF -> target geneTRANSFAC
SP1_HUMANE2F1_HUMANTF -> target geneTRANSFAC
NRF1_HUMANE2F1_HUMANTF -> target geneTRANSFAC
E2F1_HUMANCY1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05223Non-small cell lung cancer
hsa05219Bladder cancer
hsa05218Melanoma
hsa05220Chronic myeloid leukemia
hsa05200Pathways in cancer
hsa05215Prostate cancer
hsa05212Pancreatic cancer
hsa05222Small cell lung cancer
hsa04110Cell cycle
hsa05214Glioma
hsa05166HTLV-I infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0035189Rb-E2F complexIDAcellular_component
GO:0005667transcription factor complexIEAcellular_component
GO:0000085G2 phase of mitotic cell cycleTASbiological_process
GO:0000122negative regulation of transcription from RNA polyIMPbiological_process
GO:0008283cell proliferationTASbiological_process
GO:0051726regulation of cell cycleIEAbiological_process
GO:0071930negative regulation of transcription involved in GIMPbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0048255mRNA stabilizationIDAbiological_process
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0048146positive regulation of fibroblast proliferationIMPbiological_process
GO:0006915apoptotic processIMPbiological_process
GO:0010628positive regulation of gene expressionIDAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:2000045regulation of G1/S transition of mitotic cell cyclIMPbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIMPbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0000077DNA damage checkpointIMPbiological_process
GO:0003714transcription corepressor activityTASmolecular_function
GO:0000080G1 phase of mitotic cell cycleTASbiological_process
GO:0001047core promoter bindingIDAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIMPbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0071398cellular response to fatty acidIEAbiological_process
GO:0071456cellular response to hypoxiaIEAbiological_process
GO:0003677DNA bindingIMPmolecular_function
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0007283spermatogenesisIEAbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0005654nucleoplasmTAScellular_component