Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CRTC2_HUMAN
Description:CREB regulated transcription coactivator 2 [Source:HGNC Symbol;Acc:27301]
Location:chr1 q21.3
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S489PPYPYsSPSLVPhosphoSitePlus; HPRD; RegPhos
T169SALNRtSSDSARegPhos
S171LNRTSsDSALHNuaK2RegPhos
Y67TRSSHyGGSLPTORC_NPhosphoSitePlus
T3GANGHPRD
S433RRVPLsPLSLLPhosphoSitePlus; HPRD; RegPhos; SysPTM
S393GHPSLsAPALSPhosphoSitePlus; HPRD; RegPhos
T177DSALHtSVMNPHPRD; RegPhos
Y488LPPYPySSPSLPhosphoSitePlus; HPRD
S398SAPALsSSSSSPhosphoSitePlus
S348LQSSLsNPNLQSIK1HPRD
S348LQSSLsNPNLQSIK3HPRD
S368LQGSHsHPSLPPhosphoSitePlus; HPRD; RegPhos
T462PTMSPtLSSITHPRD
T192TYPGPtPPSILTORC_MPhosphoSitePlus
S173RTSSDsALHTSTORC_MPhosphoSitePlus
S90QSPLHsPLDSSPhosphoSitePlus; HPRD; RegPhos
S492PYSSPsLVLPTPhosphoSitePlus; HPRD; RegPhos
S70SHYGGsLPNVNSIK1HPRD; SysPTM
S70SHYGGsLPNVNSIK3HPRD; SysPTM
S366PQLQGsHSHPSHPRD
S386VLPTTsLGHPSPhosphoSitePlus
S436PLSPLsLLAGPPhosphoSitePlus
S164LFRLPsALNRTPhosphoSitePlus
Y486QRLPPyPYSSPHPRD
S624LTGDSsPGFSKHPRD
S624LTGDSsPGFSKTORC_CPhosphoSitePlus
S306LSGGNsTSNLTHPRD; RegPhos
S490PYPYSsPSLVLPhosphoSitePlus; HPRD
S447ADARRsQQQLPPhosphoSitePlus
S64LAYTRsSHYGGTORC_NPhosphoSitePlus
S136SPAYLsPPPESPhosphoSitePlus; HPRD; RegPhos
S131DSSPYsPAYLSPhosphoSitePlus
S171LNRTSsDSALHTORC_MPhosphoSitePlus
S94HSPLDsSRSTRPhosphoSitePlus
S375PSLPAsSLARHHPRD
S170ALNRTsSDSALTORC_MPhosphoSitePlus
T497SLVLPtQPHTPPhosphoSitePlus
S70SHYGGsLPNVNHPRD; RegPhos; SysPTM
T169SALNRtSSDSATORC_MPhosphoSitePlus
S613CSRHGsGPNIIPhosphoSitePlus; HPRD; RegPhos
S173RTSSDsALHTSHPRD
S336APGLHsPLSHPPhosphoSitePlus
S128RHIDSsPYSPAPhosphoSitePlus
S348LQSSLsNPNLQPhosphoSitePlus
S456LPKQFsPTMSPPhosphoSitePlus; HPRD; RegPhos
Y134PYSPAyLSPPPPhosphoSitePlus
S127TRHIDsSPYSPPhosphoSitePlus
S399APALSsSSSSSPhosphoSitePlus
S342PLSHPsLQSSLPhosphoSitePlus
Y130IDSSPySPAYLPhosphoSitePlus; HPRD
S64LAYTRsSHYGGHPRD
Y67TRSSHyGGSLPHPRD
S86LAEFQsPLHSPPhosphoSitePlus; HPRD
T177DSALHtSVMNPTORC_MPhosphoSitePlus
S391SLGHPsLSAPAPhosphoSitePlus
S4ANGPHPRD
S460FSPTMsPTLSSPhosphoSitePlus; HPRD
S424STPGAsPHHRRPhosphoSitePlus
S116PRRMVsPLRRYPhosphoSitePlus
S419PSYPAsTPGASPhosphoSitePlus
S70SHYGGsLPNVNTORC_NPhosphoSitePlus; SysPTM
T458KQFSPtMSPTLHPRD
S79VNQIGsGLAEFPhosphoSitePlus; HPRD
S171LNRTSsDSALHSIK3HPRD
S171LNRTSsDSALHSIK2HPRD
S171LNRTSsDSALHSIK1HPRD
S623ILTGDsSPGFSTORC_CPhosphoSitePlus
T501PTQPHtPKSLQPhosphoSitePlus; HPRD

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S171SALNRTSsDSALHTSHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000357622S516LCOSMICHead and Neck Cancer21798893
ENSP00000357622R200QBIOMARTBreast Cancer21930507, 21930502
ENSP00000357622R200*COSMICOvarian Cancer21720365
ENSP00000357622G626CCOSMICOvarian Cancer21720365
ENSP00000357622K233NCOSMICHead and Neck Cancer21798893

Differential expressed protein
CRTC2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CRTC2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SIK2_HUMANCRTC2_HUMANkinase -> substrateHPRD
ZAGL2_HUMANCRTC2_HUMANkinase -> substrateRegPhos
SIK3_HUMANCRTC2_HUMANkinase -> substrateHPRD
SIK1_HUMANCRTC2_HUMANkinase -> substrateHPRD
CRTC2_HUMANIL8_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05166HTLV-I infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051289protein homotetramerizationIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0042593glucose homeostasisISSbiological_process
GO:0008140cAMP response element binding protein bindingIEAmolecular_function
GO:0032793positive regulation of CREB transcription factor aIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0006094gluconeogenesisISSbiological_process
GO:0042593glucose homeostasisIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005737cytoplasmISScellular_component
GO:0006094gluconeogenesisIEAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0032793positive regulation of CREB transcription factor aISSbiological_process


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