| UniProt/SwissProt ID: | CRTC2_HUMAN |
| Description: | CREB regulated transcription coactivator 2 [Source:HGNC Symbol;Acc:27301] |
| Location: | chr1 q21.3 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S489 | PPYPYsSPSLV | PhosphoSitePlus; HPRD; RegPhos | |
| T169 | SALNRtSSDSA | RegPhos | |
| S171 | LNRTSsDSALH | NuaK2 | RegPhos |
| Y67 | TRSSHyGGSLP | TORC_N | PhosphoSitePlus |
| T3 | GANG | HPRD | |
| S433 | RRVPLsPLSLL | PhosphoSitePlus; HPRD; RegPhos; SysPTM | |
| S393 | GHPSLsAPALS | PhosphoSitePlus; HPRD; RegPhos | |
| T177 | DSALHtSVMNP | HPRD; RegPhos | |
| Y488 | LPPYPySSPSL | PhosphoSitePlus; HPRD | |
| S398 | SAPALsSSSSS | PhosphoSitePlus | |
| S348 | LQSSLsNPNLQ | SIK1 | HPRD |
| S348 | LQSSLsNPNLQ | SIK3 | HPRD |
| S368 | LQGSHsHPSLP | PhosphoSitePlus; HPRD; RegPhos | |
| T462 | PTMSPtLSSIT | HPRD | |
| T192 | TYPGPtPPSIL | TORC_M | PhosphoSitePlus |
| S173 | RTSSDsALHTS | TORC_M | PhosphoSitePlus |
| S90 | QSPLHsPLDSS | PhosphoSitePlus; HPRD; RegPhos | |
| S492 | PYSSPsLVLPT | PhosphoSitePlus; HPRD; RegPhos | |
| S70 | SHYGGsLPNVN | SIK1 | HPRD; SysPTM |
| S70 | SHYGGsLPNVN | SIK3 | HPRD; SysPTM |
| S366 | PQLQGsHSHPS | HPRD | |
| S386 | VLPTTsLGHPS | PhosphoSitePlus | |
| S436 | PLSPLsLLAGP | PhosphoSitePlus | |
| S164 | LFRLPsALNRT | PhosphoSitePlus | |
| Y486 | QRLPPyPYSSP | HPRD | |
| S624 | LTGDSsPGFSK | HPRD | |
| S624 | LTGDSsPGFSK | TORC_C | PhosphoSitePlus |
| S306 | LSGGNsTSNLT | HPRD; RegPhos | |
| S490 | PYPYSsPSLVL | PhosphoSitePlus; HPRD | |
| S447 | ADARRsQQQLP | PhosphoSitePlus | |
| S64 | LAYTRsSHYGG | TORC_N | PhosphoSitePlus |
| S136 | SPAYLsPPPES | PhosphoSitePlus; HPRD; RegPhos | |
| S131 | DSSPYsPAYLS | PhosphoSitePlus | |
| S171 | LNRTSsDSALH | TORC_M | PhosphoSitePlus |
| S94 | HSPLDsSRSTR | PhosphoSitePlus | |
| S375 | PSLPAsSLARH | HPRD | |
| S170 | ALNRTsSDSAL | TORC_M | PhosphoSitePlus |
| T497 | SLVLPtQPHTP | PhosphoSitePlus | |
| S70 | SHYGGsLPNVN | HPRD; RegPhos; SysPTM | |
| T169 | SALNRtSSDSA | TORC_M | PhosphoSitePlus |
| S613 | CSRHGsGPNII | PhosphoSitePlus; HPRD; RegPhos | |
| S173 | RTSSDsALHTS | HPRD | |
| S336 | APGLHsPLSHP | PhosphoSitePlus | |
| S128 | RHIDSsPYSPA | PhosphoSitePlus | |
| S348 | LQSSLsNPNLQ | PhosphoSitePlus | |
| S456 | LPKQFsPTMSP | PhosphoSitePlus; HPRD; RegPhos | |
| Y134 | PYSPAyLSPPP | PhosphoSitePlus | |
| S127 | TRHIDsSPYSP | PhosphoSitePlus | |
| S399 | APALSsSSSSS | PhosphoSitePlus | |
| S342 | PLSHPsLQSSL | PhosphoSitePlus | |
| Y130 | IDSSPySPAYL | PhosphoSitePlus; HPRD | |
| S64 | LAYTRsSHYGG | HPRD | |
| Y67 | TRSSHyGGSLP | HPRD | |
| S86 | LAEFQsPLHSP | PhosphoSitePlus; HPRD | |
| T177 | DSALHtSVMNP | TORC_M | PhosphoSitePlus |
| S391 | SLGHPsLSAPA | PhosphoSitePlus | |
| S4 | ANGP | HPRD | |
| S460 | FSPTMsPTLSS | PhosphoSitePlus; HPRD | |
| S424 | STPGAsPHHRR | PhosphoSitePlus | |
| S116 | PRRMVsPLRRY | PhosphoSitePlus | |
| S419 | PSYPAsTPGAS | PhosphoSitePlus | |
| S70 | SHYGGsLPNVN | TORC_N | PhosphoSitePlus; SysPTM |
| T458 | KQFSPtMSPTL | HPRD | |
| S79 | VNQIGsGLAEF | PhosphoSitePlus; HPRD | |
| S171 | LNRTSsDSALH | SIK3 | HPRD |
| S171 | LNRTSsDSALH | SIK2 | HPRD |
| S171 | LNRTSsDSALH | SIK1 | HPRD |
| S623 | ILTGDsSPGFS | TORC_C | PhosphoSitePlus |
| T501 | PTQPHtPKSLQ | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S171 | SALNRTSsDSALHTS | HPRD | |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000357622 | S516L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000357622 | R200Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000357622 | R200* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000357622 | G626C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000357622 | K233N | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| CRTC2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CRTC2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SIK2_HUMAN | CRTC2_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | CRTC2_HUMAN | kinase -> substrate | RegPhos |
| SIK3_HUMAN | CRTC2_HUMAN | kinase -> substrate | HPRD |
| SIK1_HUMAN | CRTC2_HUMAN | kinase -> substrate | HPRD |
| CRTC2_HUMAN | IL8_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05166 | HTLV-I infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0051289 | protein homotetramerization | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0042593 | glucose homeostasis | ISS | biological_process |
| GO:0008140 | cAMP response element binding protein binding | IEA | molecular_function |
| GO:0032793 | positive regulation of CREB transcription factor a | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006094 | gluconeogenesis | ISS | biological_process |
| GO:0042593 | glucose homeostasis | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005737 | cytoplasm | ISS | cellular_component |
| GO:0006094 | gluconeogenesis | IEA | biological_process |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0032793 | positive regulation of CREB transcription factor a | ISS | biological_process |