Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MEF2A_HUMAN
Description:myocyte enhancer factor 2A [Source:HGNC Symbol;Acc:6993]
Location:chr15 q26.3
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S496DRESPsVKRMRPhosphoSitePlus
S235VNSRAsPNLIGPhosphoSitePlus; HPRD; phosphoELM
T304TQPLAtPVVSVMAPK14HPRD
T319VVSVTtPSLPPMAPK7phosphoELM
T108TSYVLtPHTEEHPRD; phosphoELM; RegPhos
T319VVSVTtPSLPPMAPK14phosphoELM
T319VVSVTtPSLPPPhosphoSitePlus
S289MMPPLsEEEELPhosphoSitePlus
T253GKVMPtKSPPPPhosphoSitePlus
S104PDPDTsYVLTPHJURP_CPhosphoSitePlus
S453QEMGRsPVDSLp38aRegPhos
S408KSEPIsPPRDRPhosphoSitePlus; RegPhos
T311VVSVTtPSLPPMAPK7HPRD
S246ATGANsLGKVMPhosphoSitePlus
T319VVSVTtPSLPPp38a(MAPK14RegPhos
T103SPDPDtSYVLTHJURP_CPhosphoSitePlus
T108TSYVLtPHTEEHJURP_CPhosphoSitePlus
S400KSEPIsPPRDRCDK5HPRD
T304TQPLAtPVVSVMAPK7HPRD
T319VVSVTtPSLPPp38aRegPhos
T312TQPLAtPVVSVMAPK7phosphoELM
S98HRGCDsPDPDTHJURP_CPhosphoSitePlus
S479RGDFHsPIVLGPhosphoSitePlus
S408KSEPIsPPRDRCDK5phosphoELM; RegPhos
Y105DPDTSyVLTPHHJURP_CPhosphoSitePlus
S355LQGFNsPGMLSErk5(MAPK7RegPhos
S355LQGFNsPGMLSErk5RegPhos
T319VVSVTtPSLPPErk5(MAPK7RegPhos
Y115HTEEKyKKINEHJURP_CPhosphoSitePlus
T319VVSVTtPSLPPErk5RegPhos
S98HRGCDsPDPDTHPRD; phosphoELM; RegPhos
T312TQPLAtPVVSVp38aRegPhos
T311VVSVTtPSLPPMAPK14HPRD
S223NGAGSsPVGNGPhosphoSitePlus
S289MMPPLsEEEELCK2_alphaphosphoELM
S408KSEPIsPPRDRp38a(MAPK14RegPhos
S355LQGFNsPGMLSPhosphoSitePlus
S445QEMGRsPVDSLMAPK14HPRD
S453QEMGRsPVDSLMAPK14phosphoELM
T111VLTPHtEEKYKHJURP_CPhosphoSitePlus
S453QEMGRsPVDSLp38a(MAPK14RegPhos
S494TEDREsPSVKRPhosphoSitePlus
S59LFQYAsTDMDKSRF-TFPhosphoSitePlus
T312TQPLAtPVVSVErk5RegPhos
S192LHRNVsPGAPQPhosphoSitePlus
S457RSPVDsLSSSSPhosphoSitePlus
S347LQGFNsPGMLSMAPK7HPRD
T312TQPLAtPVVSVMAPK14phosphoELM
S289MMPPLsEEEELCK2a1(CK2 alphaRegPhos
S408KSEPIsPPRDRMAPK14phosphoELM
T312TQPLAtPVVSVErk5(MAPK7RegPhos
S355LQGFNsPGMLSMAPK7phosphoELM
T312TQPLAtPVVSVp38a(MAPK14RegPhos
S488DRESPsVKRMRHPRD
T312TQPLAtPVVSVPhosphoSitePlus
S255VMPTKsPPPPGPhosphoSitePlus; HPRD; phosphoELM; RegPhos

Dephosphorylation site
MEF2A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000346389L273VBIOMARTBreast Cancer21930507, 21930502
ENSP00000404110S369TTCGAOvarian Cancer21720365, 18772890
ENSP00000453441S369TTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
MEF2A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MEF2A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK14_HUMANMEF2A_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANMEF2A_HUMANkinase -> substrateRegPhos
CDK5_HUMANMEF2A_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
MK09_HUMANMEF2A_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANMEF2A_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANMEF2A_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANMEF2A_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MEF2A_HUMANMYOG_HUMANTF -> target geneTRANSFAC
MEF2A_HUMANPRVA_HUMANTF -> target geneTRANSFAC
MEF2A_HUMANENOB_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
MEF2A_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006366transcription from RNA polymerase II promoterIDAbiological_process
GO:0002467germinal center formationIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0042100B cell proliferationIEAbiological_process
GO:0048703embryonic viscerocranium morphogenesisIEAbiological_process
GO:0060045positive regulation of cardiac muscle cell prolifeIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0000165MAPK cascadeIEAbiological_process
GO:0055005ventricular cardiac myofibril developmentISSbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0045669positive regulation of osteoblast differentiationIEAbiological_process
GO:0000987core promoter proximal region sequence-specific DNIEAmolecular_function
GO:0021542dentate gyrus developmentIEAbiological_process
GO:0001085RNA polymerase II transcription factor bindingIPImolecular_function
GO:0019901protein kinase bindingIEAmolecular_function
GO:0072102glomerulus morphogenesisIEAbiological_process
GO:0035984cellular response to trichostatin AIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0090073positive regulation of protein homodimerization acIEAbiological_process
GO:2001013epithelial cell proliferation involved in renal tuIEAbiological_process
GO:0014898cardiac muscle hypertrophy in response to stressIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0045652regulation of megakaryocyte differentiationIEAbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0042826histone deacetylase bindingIEAmolecular_function
GO:2000987positive regulation of behavioral fear responseIEAbiological_process
GO:0071277cellular response to calcium ionIEAbiological_process
GO:0061337cardiac conductionISSbiological_process
GO:0071333cellular response to glucose stimulusIEAbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0001568blood vessel developmentIEAbiological_process
GO:0050680negative regulation of epithelial cell proliferatiIEAbiological_process
GO:0045666positive regulation of neuron differentiationIEAbiological_process
GO:0061337cardiac conductionIEAbiological_process
GO:0000165MAPK cascadeIDAbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0003185sinoatrial valve morphogenesisIEAbiological_process
GO:0007611learning or memoryIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0003138primary heart field specificationIEAbiological_process
GO:0060021palate developmentIEAbiological_process
GO:0001958endochondral ossificationIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0048311mitochondrion distributionIEAbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0033197response to vitamin EIEAbiological_process
GO:0048311mitochondrion distributionISSbiological_process
GO:0042692muscle cell differentiationTASbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0071300cellular response to retinoic acidIEAbiological_process
GO:0007517muscle organ developmentNASbiological_process
GO:0050853B cell receptor signaling pathwayIEAbiological_process
GO:0051145smooth muscle cell differentiationIEAbiological_process
GO:0000981sequence-specific DNA binding RNA polymerase II trIDAmolecular_function
GO:0030501positive regulation of bone mineralizationIEAbiological_process
GO:0000977RNA polymerase II regulatory region sequence-speciIEAmolecular_function
GO:0051149positive regulation of muscle cell differentiationTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0001947heart loopingIEAbiological_process
GO:0002062chondrocyte differentiationIEAbiological_process
GO:0070375ERK5 cascadeIMPbiological_process
GO:0055005ventricular cardiac myofibril developmentIEAbiological_process
GO:0072160nephron tubule epithelial cell differentiationIEAbiological_process
GO:0030224monocyte differentiationIEAbiological_process
GO:0046332SMAD bindingIPImolecular_function
GO:0060536cartilage morphogenesisIEAbiological_process
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0007507heart developmentIEPbiological_process
GO:2000111positive regulation of macrophage apoptotic procesIEAbiological_process
GO:0060025regulation of synaptic activityIEAbiological_process
GO:0071864positive regulation of cell proliferation in bone IEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0042826histone deacetylase bindingIPImolecular_function
GO:0007521muscle cell fate determinationIEAbiological_process
GO:0000790nuclear chromatinISScellular_component
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0030220platelet formationIEAbiological_process
GO:0035690cellular response to drugIEAbiological_process
GO:0033613activating transcription factor bindingIEAmolecular_function
GO:0030318melanocyte differentiationIEAbiological_process
GO:0003139secondary heart field specificationIEAbiological_process
GO:0001046core promoter sequence-specific DNA bindingIEAmolecular_function
GO:0003151outflow tract morphogenesisIEAbiological_process
GO:0043565sequence-specific DNA bindingIDAmolecular_function
GO:0000790nuclear chromatinIEAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0048813dendrite morphogenesisISSbiological_process
GO:0002634regulation of germinal center formationIEAbiological_process
GO:0071222cellular response to lipopolysaccharideIEAbiological_process
GO:0030890positive regulation of B cell proliferationIEAbiological_process
GO:0060297regulation of sarcomere organizationIEAbiological_process
GO:0014033neural crest cell differentiationIEAbiological_process
GO:0001782B cell homeostasisIEAbiological_process
GO:0010694positive regulation of alkaline phosphatase activiIEAbiological_process
GO:0048666neuron developmentIEAbiological_process
GO:0001105RNA polymerase II transcription coactivator activiIDAmolecular_function
GO:0008063Toll signaling pathwayTASbiological_process
GO:2000727positive regulation of cardiac muscle cell differeIEAbiological_process
GO:0000977RNA polymerase II regulatory region sequence-speciIDAmolecular_function
GO:0000002mitochondrial genome maintenanceISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0071498cellular response to fluid shear stressIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0000002mitochondrial genome maintenanceIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0001649osteoblast differentiationIEAbiological_process
GO:0006959humoral immune responseIEAbiological_process
GO:0006351transcription, DNA-dependentIDAbiological_process
GO:0003211cardiac ventricle formationIEAbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0035914skeletal muscle cell differentiationIEAbiological_process
GO:0033613activating transcription factor bindingIPImolecular_function
GO:0001974blood vessel remodelingIEAbiological_process
GO:0071837HMG box domain bindingIEAmolecular_function
GO:0046983protein dimerization activityIEAmolecular_function
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0035035histone acetyltransferase bindingIPImolecular_function
GO:0071277cellular response to calcium ionIDAbiological_process
GO:0001077RNA polymerase II core promoter proximal region seIEAmolecular_function