Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SRC8_HUMAN
Description:cortactin [Source:HGNC Symbol;Acc:3338]
Location:chr11 q13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T399QARAKtQTPPVPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y289AVGFDyKEKLAHS1_repPhosphoSitePlus
S405QTPPVsPAPQPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S109YQSKLsKHCSQHS1_repPhosphoSitePlus
Y446EPEPVySMEAAPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y191ESQRDySKGFGHS1_repPhosphoSitePlus
S438YRGPVsGTEPEPhosphoSitePlus
S282SERQDsAAVGFHS1_repPhosphoSitePlus
Y310GFGGKyGVQKDHS1_repPhosphoSitePlus
T182DYQGKtEKHESHPRD; RegPhos
S405QTPPVsPAPQPMAPK3phosphoELM
S417EERLPsSPVYEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T323DKNAStFEDVTHS1_repPhosphoSitePlus
Y446EPEPVySMEAAFGFR1phosphoELM; RegPhos; SysPTM
S209DKVDKsAVGFEHPRD; RegPhos
T24ADDWEtDPDFVPhosphoSitePlus; HPRD; RegPhos
T364RAKTQtPPVSPHPRD
S311VTSKTsNIRANHPRD
S348VTSKTsNIRANPhosphoSitePlus; HPRD; RegPhos
S156QKDYSsGFGGKHS1_repPhosphoSitePlus
S389YEDAAsFKAELHPRD
Y384PSSPVyEDAASFERHPRD
S447PEPVYsMEAADPhosphoSitePlus
S308VEAVTsKTSNIHPRD
T411PAPQPtEERLPPhosphoSitePlus; HPRD
Y470ATEAVyESAEAPhosphoSitePlus
Y104AVGHEyQSKLSHS1_repPhosphoSitePlus
Y141AVGFEyQGKTEHS1_repPhosphoSitePlus
Y464QQGLAyATEAVPhosphoSitePlus
Y538VCKGRyGLFPASH3_1PhosphoSitePlus
Y297QVSSAyQKTVPHPRD
S368QTPPVsPAPQPHPRD
S11AGHAVsIAQDDPhosphoSitePlus; HPRD; RegPhos
Y289AVGFDyKEKLAHPRD
Y421PSSPVyEDAASSrcRegPhos; SysPTM
Y421PSSPVyEDAASSRCHPRD; RegPhos; SysPTM
S113LSKHCsQVDSVHS1_repPhosphoSitePlus; SysPTM
Y215AVGFEyQGKTERegPhos
T267QKDYKtGFGGKHS1_repPhosphoSitePlus
Y215AVGFEyQGKTEHS1_repPhosphoSitePlus
Y433KAELSyRGPVSPhosphoSitePlus; HPRD
S33FVNDVsEKEQRPhosphoSitePlus
Y486AEDSTyDEYENSrcRegPhos
T362QARAKtQTPPVHPRD
Y409EPEPVySMEAAHPRD
Y334QVSSAyQKTVPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S298LAKHEsQQDYSHS1_repPhosphoSitePlus
Y302ESQQDySKGFGHS1_repPhosphoSitePlus
S322MDKNAsTFEDVHS1_repPhosphoSitePlus
Y486AEDSTyDEYENSRCHPRD; phosphoELM; RegPhos
Y545LFPANyVELRQPhosphoSitePlus
Y396KAELSyRGPVSHPRD
S303SQQDYsKGFGGHS1_repPhosphoSitePlus
S117CSQVDsVRGFGHS1_repPhosphoSitePlus; SysPTM
Y84KASHGyGGKFGHS1_repPhosphoSitePlus
Y453MEAADyREASSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T401RAKTQtPPVSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S432FKAELsYRGPVPhosphoSitePlus
Y384PSSPVyEDAASSRCHPRD
S172DRVDKsAVGFDHPRD; RegPhos
Y228ESQKDyVKGFGHS1_repPhosphoSitePlus
Y433ATEAVyESAEASRCHPRD
S418ERLPSsPVYEDMAPK3phosphoELM; SysPTM
Y265ESQKDyKTGFGHS1_repPhosphoSitePlus
T219EYQGKtEKHESHS1_repPhosphoSitePlus
Y162GFGGKyGVQADHS1_repPhosphoSitePlus
S150TEKHAsQKDYSHPRD; RegPhos
S345VEAVTsKTSNIPhosphoSitePlus; HPRD; RegPhos
Y154ASQKDySSGFGHS1_repPhosphoSitePlus
S418ERLPSsPVYEDErk1(MAPK3RegPhos; SysPTM
S261LQLHEsQKDYSHPRD
T182DYQGKtEKHESHS1_repPhosphoSitePlus
S282SERQDsAAVGFHPRD; RegPhos
Y421PSSPVyEDAASFERHPRD; RegPhos; SysPTM
S381ERLPSsPVYEDHPRD
S380EERLPsSPVYEHPRD
Y479EAPGHyPAEDSPhosphoSitePlus
T440GPVSGtEPEPVPhosphoSitePlus
Y470ATEAVyESAEASRCHPRD; phosphoELM; RegPhos
T43RWGAKtVQGSGPhosphoSitePlus
Y178AVGFDyQGKTEHS1_repPhosphoSitePlus
Y470ATEAVyESAEASrcRegPhos
S426YEDAAsFKAELPhosphoSitePlus; HPRD; phosphoELM
S117CSQVDsVRGFGHPRD; phosphoELM; RegPhos; SysPTM
Y416MEAADyREASSHPRD
Y141AVGFEyQGKTEHPRD; phosphoELM
T485PAEDStYDEYEPhosphoSitePlus
S405QTPPVsPAPQPErk1(MAPK3RegPhos
Y449AEDSTyDEYENSRCHPRD
S155SQKDYsSGFGGHS1_repPhosphoSitePlus
S418ERLPSsPVYEDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y421PSSPVyEDAASPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
T374PAPQPtEERLPHPRD
Y433KAELSyRGPVSSRCRegPhos
S150TEKHAsQKDYSHS1_repPhosphoSitePlus
Y486AEDSTyDEYENPhosphoSitePlus
S135DRVDQsAVGFEHPRD; RegPhos
S261LQLHEsQKDYKHPRD
S261LQLHEsQKDYKHS1_repPhosphoSitePlus
S113LSKHCsQVDSVHPRD; phosphoELM; RegPhos; SysPTM

Dephosphorylation site
SRC8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000317189T364MBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000317189G457RBIOMARTBreast Cancer21930507, 21930502
ENSP00000317189E375KBIOMARTBreast Cancer21930507, 21930502
ENSP00000301843G494RBIOMARTBreast Cancer21930507, 21930502
ENSP00000365745T364MBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000301843G311ACOSMICOvarian Cancer21720365
ENSP00000301843E412KBIOMARTBreast Cancer21930507, 21930502
ENSP00000365745G274ATCGAOvarian Cancer21720365, 18772890
ENSP00000301843T401MBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000301843Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.3518646787
ENSP00000301843Breast CancerNormal vs. Cancercell lineDown0.7320543960
ENSP00000301843Uterine CancerTreatment(none vs. 5-Fluorouracil treatment)cell lineDown15585135

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y446GTEPEPVySMEAADYcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
CDK4_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
KPCL_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
DDR2_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
STK38_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
MP2K4_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANSRC8_HUMANkinase -> substrateRegPhos
SLTM_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
M4K5_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
KCC2D_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
FER_HUMANSRC8_HUMANkinase -> substrateHPRD; RegPhos
GSK3B_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
PAK4_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
RET_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
CSK22_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
CDK3_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
ZAP70_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
AURKB_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
STYK1_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
FGFR1_HUMANSRC8_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
LCK_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
STK24_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
CDKL3_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
ST38L_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
KC1A_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
BMX_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
ARBK1_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
IGF1R_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
SRC_HUMANSRC8_HUMANkinase -> substrateRegPhos
KPCA_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05130Pathogenic Escherichia coli infection
hsa05100Bacterial invasion of epithelial cells
hsa04530Tight junction
hsa05131Shigellosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005856cytoskeletonIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0030027lamellipodiumIEAcellular_component
GO:0001726ruffleIEAcellular_component
GO:0005938cell cortexIEAcellular_component
GO:0005737cytoplasmISScellular_component


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