Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TFE3_HUMAN
Description:transcription factor binding to IGHM enhancer 3 [Source:HGNC Symbol;Acc:11752]
Location:chrX p11.23
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S560VSPAVsKASSRHPRD
S542SGGALsPLRAAHPRD
S548PLRAAsDPLLSHPRD
S101SSAGGsRTPAMPhosphoSitePlus
S560VSPAVsKASSRDUF3371PhosphoSitePlus
S554DPLLSsVSPAVHPRD
S246GSAPNsPMALLHPRD
S568SSRRSsFSMEEHPRD
S568SSRRSsFSMEEDUF3371PhosphoSitePlus
T236PEAAHtTGPTGHPRD
S556LLSSVsPAVSKHPRD
S553SDPLLsSVSPAHPRD
S542SGGALsPLRAADUF3371PhosphoSitePlus
T217ASQALtPPPGPHPRD
S567ASSRRsSFSMEDUF3371PhosphoSitePlus
S257TIGSSsEKEIDHPRD
S112SSSSSsRVLLRPhosphoSitePlus
S556LLSSVsPAVSKDUF3371PhosphoSitePlus
S548PLRAAsDPLLSDUF3371PhosphoSitePlus
S575SMEEEs_____DUF3371PhosphoSitePlus

Dephosphorylation site
TFE3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000314129A125TCOSMICCentral Nervous System Neoplasms18772396
ENSP00000314129P219LBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
TFE3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TFE3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STK11_HUMANTFE3_HUMANkinase -> substrateRobert H Newman (2013)
TFE3_HUMANPAI1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
TFE3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006959humoral immune responseISSbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0046983protein dimerization activityIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0045670regulation of osteoclast differentiationIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0044212transcription regulatory region DNA bindingISSmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0003700sequence-specific DNA binding transcription factorISSmolecular_function
GO:0005737cytoplasmIDAcellular_component


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