| UniProt/SwissProt ID: | ETS2_HUMAN |
| Description: | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) [Source:HGNC Symbol;Acc:3489] |
| Location: | chr21 q22.2 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S321 | DDCSQsLCLNK | PhosphoSitePlus | |
| T72 | ELPLLtPCSKA | PhosphoSitePlus; HPRD; phosphoELM | |
| S295 | DSLLQsWNSQS | PhosphoSitePlus; HPRD; SysPTM | |
| T226 | MCPAStPSVLS | PhosphoSitePlus | |
| S246 | KSRLSsVSVTY | PhosphoSitePlus | |
| S228 | PASTPsVLSSE | PhosphoSitePlus | |
| S313 | VPSFEsFEDDC | PhosphoSitePlus | |
| S319 | FEDDCsQSLCL | PhosphoSitePlus | |
| S310 | VQRVPsFESFE | PhosphoSitePlus | |
| Dephosphorylation site |
| ETS2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000353344 | G216S | COSMIC | Breast Cancer | 20668451 | ENSP00000353344 | G356C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000353344 | T72A | COSMIC | Lung Cancer | 20016488 | ENSP00000354194 | P362S | COSMIC | Skin Cancer | 21984974 | ENSP00000353344 | W117L | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000354194 | G216S | COSMIC | Breast Cancer | 20668451 | ENSP00000354194 | Q137E | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000354194 | W117L | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000354194 | G356C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000354194 | T72A | COSMIC | Lung Cancer | 20016488 | ENSP00000353344 | P362S | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| ETS2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ETS2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ETS2_HUMAN | TRBC1_HUMAN | TF -> target gene | TRANSFAC |
| ETS2_HUMAN | IL12B_HUMAN | TF -> target gene | TRANSFAC |
| ETS2_HUMAN | FOSL1_HUMAN | TF -> target gene | TRANSFAC |
| ETS2_HUMAN | CDK1_HUMAN | TF -> target gene | TRANSFAC |
| ETS2_HUMAN | PSN1_HUMAN | TF -> target gene | TRANSFAC |
| ETS2_HUMAN | SURF1_HUMAN | TF -> target gene | TRANSFAC |
| ETS2_HUMAN | MGAT2_HUMAN | TF -> target gene | TRANSFAC |
| ETS2_HUMAN | CCND1_HUMAN | TF -> target gene | TRANSFAC |
| ETS2_HUMAN | UROK_HUMAN | TF -> target gene | TRANSFAC |
| ETS2_HUMAN | KIT_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| ETS2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0000977 | RNA polymerase II regulatory region sequence-speci | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0003700 | sequence-specific DNA binding transcription factor | IDA | molecular_function |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0035259 | glucocorticoid receptor binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0001501 | skeletal system development | TAS | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |