| UniProt/SwissProt ID: | NFYB_HUMAN |
| Description: | nuclear transcription factor Y, beta [Source:HGNC Symbol;Acc:7805] |
| Location: | chr12 q23.3 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T112 | QEKRKtINGED | CBFD_NFYB_HMF | PhosphoSitePlus |
| T2 | ____MtMDGDS | PhosphoSitePlus | |
| Dephosphorylation site |
| NFYB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000447486 | Y58S | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000240055 | Y58S | COSMIC | Head and Neck Cancer | 21798897 |
| Differential expressed protein |
| NFYB_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NFYB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NFYB_HUMAN | TGFR2_HUMAN | TF -> target gene | TRANSFAC |
| NFYB_HUMAN | MDR1_HUMAN | TF -> target gene | TRANSFAC |
| NFYB_HUMAN | CDK1_HUMAN | TF -> target gene | TRANSFAC |
| NFYB_HUMAN | MYBA_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| NFYB_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0070491 | repressing transcription factor binding | IPI | molecular_function |
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0016602 | CCAAT-binding factor complex | IDA | cellular_component |
| GO:0006355 | regulation of transcription, DNA-dependent | IDA | biological_process |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |