Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HMGA2_HUMAN
Description:high mobility group AT-hook 2 [Source:HGNC Symbol;Acc:5009]
Location:chr12 q14.3
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S44PTGEPsPKRPRCDC2(CDK1RegPhos; SysPTM
S105TSSQEsAEEDRegPhos
S59GSKNKsPSKAACDC2RegPhos
S59GSKNKsPSKAACDC2(CDK1RegPhos
S105TSSQEsAEHPRD
T40QQQEPtGEPSPPhosphoSitePlus; HPRD
S12GAGQPsTSAQGPhosphoSitePlus
T97PAQEEtEETSSPhosphoSitePlus
S102TEETSsQESAEPhosphoSitePlus; HPRD
S101ETEETsSQESAPhosphoSitePlus; HPRD
S2____MsARGEGPhosphoSitePlus
S44PTGEPsPKRPRCDK1HPRD; phosphoELM; SysPTM
T100EETEEtSSQESPhosphoSitePlus; HPRD
T13AGQPStSAQGQPhosphoSitePlus
S59GSKNKsPSKAACDK1HPRD; phosphoELM
S105TSSQEsAEED_PhosphoSitePlus
S44PTGEPsPKRPRPhosphoSitePlus; SysPTM
S14GQPSTsAQGQPPhosphoSitePlus; HPRD
S44PTGEPsPKRPRCDC2RegPhos; SysPTM

Dephosphorylation site
HMGA2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000346658Q65KBIOMARTHepatocellular Carcinoma21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000346658Hepatocellular CarcinomaMetastasiscell lineUp2.119016532
ENSP00000346658Ovarian CancerMetastasiscell lineUp8.117892554

Hyperphosphorylation site
HMGA2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK1_HUMANHMGA2_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANHMGA2_HUMANkinase -> substrateRegPhos
HMGA2_HUMANB2LA1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05202Transcriptional misregulation in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0090402oncogene-induced senescenceIDAbiological_process
GO:0000988protein binding transcription factor activityIDAmolecular_function
GO:0000975regulatory region DNA bindingIDAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0003906DNA-(apurinic or apyrimidinic site) lyase activityIDAmolecular_function
GO:0021983pituitary gland developmentIEAbiological_process
GO:0006284base-excision repairIDAbiological_process
GO:0001071nucleic acid binding transcription factor activityIDAmolecular_function
GO:0043922negative regulation by host of viral transcriptionIDAbiological_process
GO:0030325adrenal gland developmentIEAbiological_process
GO:0035978histone H2A-S139 phosphorylationIDAbiological_process
GO:0035497cAMP response element bindingIDAmolecular_function
GO:0001078RNA polymerase II core promoter proximal region seIDAmolecular_function
GO:2000036regulation of stem cell maintenanceIMPbiological_process
GO:0048762mesenchymal cell differentiationIMPbiological_process
GO:0003680AT DNA bindingIDAmolecular_function
GO:2000648positive regulation of stem cell proliferationIMPbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0010628positive regulation of gene expressionIDAbiological_process
GO:0010564regulation of cell cycle processIDAbiological_process
GO:0060612adipose tissue developmentIEAbiological_process
GO:0035988chondrocyte proliferationIDAbiological_process
GO:0040018positive regulation of multicellular organism growIEAbiological_process
GO:0043392negative regulation of DNA bindingIDAbiological_process
GO:0000228nuclear chromosomeISScellular_component
GO:0004677DNA-dependent protein kinase activityIDAmolecular_function
GO:0008134transcription factor bindingIPImolecular_function
GO:0007275multicellular organismal developmentTASbiological_process
GO:0007283spermatogenesisIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0035501MH1 domain bindingIDAmolecular_function
GO:0048712negative regulation of astrocyte differentiationIEAbiological_process
GO:2001033negative regulation of double-strand break repair IDAbiological_process
GO:0006325chromatin organizationTASbiological_process
GO:0071141SMAD protein complexIDAcellular_component
GO:2000679positive regulation of transcription regulatory reIDAbiological_process
GO:0007067mitosisIEAbiological_process
GO:0035985senescence-associated heterochromatin focusIDAcellular_component
GO:0046332SMAD bindingIPImolecular_function
GO:0031052chromosome breakageIDAbiological_process
GO:0030261chromosome condensationIEAbiological_process
GO:0001047core promoter bindingIDAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:00515755'-deoxyribose-5-phosphate lyase activityIDAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0000228nuclear chromosomeIEAcellular_component
GO:0035019somatic stem cell maintenanceIEAbiological_process
GO:0007095mitotic cell cycle G2/M transition DNA damage checIDAbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0090276regulation of peptide hormone secretionIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0003131mesodermal-endodermal cell signalingIMPbiological_process
GO:0010564regulation of cell cycle processIEAbiological_process
GO:0009615response to virusIEPbiological_process
GO:0035500MH2 domain bindingIDAmolecular_function
GO:2001038regulation of cellular response to drugIDAbiological_process
GO:0045444fat cell differentiationIMPbiological_process
GO:0035986senescence-associated heterochromatin focus assembIDAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0042769DNA damage response, detection of DNA damageIDAbiological_process
GO:0002062chondrocyte differentiationIDAbiological_process
GO:2001022positive regulation of response to DNA damage stimIDAbiological_process
GO:0070742C2H2 zinc finger domain bindingIMPmolecular_function
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:2000685positive regulation of cellular response to X-rayIDAbiological_process
GO:0060123regulation of growth hormone secretionIEAbiological_process
GO:0021846cell proliferation in forebrainIEAbiological_process
GO:0001077RNA polymerase II core promoter proximal region seIDAmolecular_function
GO:0071158positive regulation of cell cycle arrestIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045869negative regulation of retroviral genome replicatiIDAbiological_process
GO:0035987endodermal cell differentiationIMPbiological_process
GO:0031507heterochromatin assemblyIDAbiological_process
GO:0031492nucleosomal DNA bindingIDAmolecular_function
GO:0045892negative regulation of transcription, DNA-dependenIMPbiological_process
GO:0048333mesodermal cell differentiationIMPbiological_process
GO:0032993protein-DNA complexIDAcellular_component
GO:0048863stem cell differentiationIEPbiological_process
GO:0003677DNA bindingNASmolecular_function
GO:0006355regulation of transcription, DNA-dependentIMPbiological_process
GO:0060613fat pad developmentIEAbiological_process
GO:0008584male gonad developmentIEAbiological_process
GO:2000774positive regulation of cellular senescenceIMPbiological_process
GO:0008301DNA binding, bendingIMPmolecular_function
GO:0001837epithelial to mesenchymal transitionIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIDAcellular_component