Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ESPL1_HUMAN
Description:extra spindle pole bodies homolog 1 (S. cerevisiae) [Source:HGNC Symbol;Acc:16856]
Location:chr12 q13.13
Node attribute:substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S330SMEAPsPPLRAHPRD
S1820PAQEAsRLQELPeptidase_C50PhosphoSitePlus
S1126PSTNSsPVLKTErk2(MAPK1RegPhos
S1126PSTNSsPVLKTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1325RQKLAsAPLRLPhosphoSitePlus
T1363PHVPFtVFEEVPhosphoSitePlus
Y1614GHRDPyATAFLPhosphoSitePlus
T1210SLNHKtPPSLVPhosphoSitePlus
S1768AQKENsSCTDKPeptidase_C50PhosphoSitePlus
S1073TQHLDsVKKVHPhosphoSitePlus; phosphoELM; RegPhos
S1122GPIAPsTNSSPHPRD; phosphoELM
S1508EILRGsDGEDSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1126PSTNSsPVLKTCDK1phosphoELM
S1501NWRKMsFEILRPhosphoSitePlus; phosphoELM; RegPhos
S1305KSVPGsEPSKTPhosphoSitePlus; phosphoELM; RegPhos
Y2104APRLKyLIGAAPhosphoSitePlus
S1316QGQKRsGRGRQPhosphoSitePlus
S325AVLSKsMEAPSHPRD
S1126PSTNSsPVLKTMAPK1phosphoELM
S1399NFSDDsDLEDPPhosphoSitePlus; HPRD; phosphoELM
S1539LRLDSsKKKLPPhosphoSitePlus
Y719VNDLNyEDKLQPhosphoSitePlus
S1769QKENSsCTDKRPeptidase_C50PhosphoSitePlus
S2118YGLPVsLR___PhosphoSitePlus
S1538LLRLDsSKKKLPhosphoSitePlus
S810RLKDHsKAAGSPhosphoSitePlus
T1111LELVAtVAKEPPhosphoSitePlus
T1771ENSSCtDKREWPeptidase_C50PhosphoSitePlus
S1545KKKLPsPCPDKPhosphoSitePlus; phosphoELM; RegPhos
S1552CPDKEsDKDLGPhosphoSitePlus; phosphoELM; RegPhos
S1126PSTNSsPVLKTCDC2(CDK1RegPhos
S1396LKVNFsDDSDLPhosphoSitePlus; HPRD; phosphoELM
S1125APSTNsSPVLKHPRD
T1346RGLPCtPKPPDPhosphoSitePlus; phosphoELM; RegPhos
S3___MRsFKRVNPhosphoSitePlus

Dephosphorylation site
ESPL1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000449831G1609CCOSMICLung Cancer
ENSP00000449831C1282FCOSMICHead and Neck Cancer21798893
ENSP00000257934C1282FCOSMICHead and Neck Cancer21798893
ENSP00000257934G1609CCOSMICLung Cancer

Differential expressed protein
ESPL1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ESPL1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK1_HUMANESPL1_HUMANkinase -> substrateRegPhos
MK01_HUMANESPL1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANESPL1_HUMANkinase -> substrateRegPhos
CHK1_HUMANESPL1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04114Oocyte meiosis
hsa04110Cell cycle

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007059chromosome segregationIEAbiological_process
GO:0008233peptidase activityIEAmolecular_function
GO:0045875negative regulation of sister chromatid cohesionNASbiological_process
GO:0000910cytokinesisNASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0045143homologous chromosome segregationIEAbiological_process
GO:0008234cysteine-type peptidase activityNASmolecular_function
GO:0006508proteolysisIEAbiological_process
GO:0040001establishment of mitotic spindle localizationNASbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0000212meiotic spindle organizationIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0045842positive regulation of mitotic metaphase/anaphase NASbiological_process
GO:0007127meiosis IIEAbiological_process
GO:0003824catalytic activityNASmolecular_function
GO:0000090mitotic anaphaseIEAbiological_process
GO:0000070mitotic sister chromatid segregationIEAbiological_process
GO:0005813centrosomeIDAcellular_component


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