Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RBBP5_HUMAN
Description:retinoblastoma binding protein 5 [Source:HGNC Symbol;Acc:9888]
Location:chr1 q32.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S188QDLVAsFRVTTHPRD
Y416PEENPyGPPPDPhosphoSitePlus
S8LELLEsFGQNYPhosphoSitePlus
T193SFRVTtGTSNTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S182VLKTDsQDLVAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S525VQAELsQPLTAPhosphoSitePlus; HPRD
T198TGTSNtTAIKSPhosphoSitePlus
T180ILVLKtDSQDLHPRD
T252DLVNRtPWKKCCDC2RegPhos
S497GKEKDsPFKPKPhosphoSitePlus; HPRD; SysPTM
S497GKEKDsPFKPKCDC2RegPhos; SysPTM
S389AAFCSsDEELEPhosphoSitePlus; HPRD; RegPhos
S388IAAFCsSDEELPhosphoSitePlus; HPRD; RegPhos
S350YEEREsGFDIERegPhos
S130VCPMKsAPVMLPhosphoSitePlus; HPRD
S138VMLTLsDSKHVHPRD
T20EEADGtLDCISPhosphoSitePlus
S350YEEREsEFDIEPhosphoSitePlus; HPRD
Y13SFGQNyPEEADPhosphoSitePlus

Dephosphorylation site
RBBP5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000356132R272WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000264515R272WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000264515W74CCOSMICHead and Neck Cancer21798893
ENSP00000264515D507fs*22COSMICLung Cancer

Differential expressed protein
RBBP5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RBBP5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK1_HUMANRBBP5_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANRBBP5_HUMANkinase -> substrateRegPhos
TTK_HUMANRBBP5_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANRBBP5_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANRBBP5_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
RBBP5_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051568histone H3-K4 methylationIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0035097histone methyltransferase complexIPIcellular_component
GO:0035064methylated histone residue bindingIDAmolecular_function
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0042800histone methyltransferase activity (H3-K4 specificIDAmolecular_function
GO:0048188Set1C/COMPASS complexIDAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0043627response to estrogen stimulusIDAbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0071339MLL1 complexIDAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process


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