| UniProt/SwissProt ID: | RBBP5_HUMAN |
| Description: | retinoblastoma binding protein 5 [Source:HGNC Symbol;Acc:9888] |
| Location: | chr1 q32.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S188 | QDLVAsFRVTT | HPRD | |
| Y416 | PEENPyGPPPD | PhosphoSitePlus | |
| S8 | LELLEsFGQNY | PhosphoSitePlus | |
| T193 | SFRVTtGTSNT | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S182 | VLKTDsQDLVA | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S525 | VQAELsQPLTA | PhosphoSitePlus; HPRD | |
| T198 | TGTSNtTAIKS | PhosphoSitePlus | |
| T180 | ILVLKtDSQDL | HPRD | |
| T252 | DLVNRtPWKKC | CDC2 | RegPhos |
| S497 | GKEKDsPFKPK | PhosphoSitePlus; HPRD; SysPTM | |
| S497 | GKEKDsPFKPK | CDC2 | RegPhos; SysPTM |
| S389 | AAFCSsDEELE | PhosphoSitePlus; HPRD; RegPhos | |
| S388 | IAAFCsSDEEL | PhosphoSitePlus; HPRD; RegPhos | |
| S350 | YEEREsGFDIE | RegPhos | |
| S130 | VCPMKsAPVML | PhosphoSitePlus; HPRD | |
| S138 | VMLTLsDSKHV | HPRD | |
| T20 | EEADGtLDCIS | PhosphoSitePlus | |
| S350 | YEEREsEFDIE | PhosphoSitePlus; HPRD | |
| Y13 | SFGQNyPEEAD | PhosphoSitePlus | |
| Dephosphorylation site |
| RBBP5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000356132 | R272W | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000264515 | R272W | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000264515 | W74C | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000264515 | D507fs*22 | COSMIC | Lung Cancer |
| Differential expressed protein |
| RBBP5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RBBP5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK1_HUMAN | RBBP5_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | RBBP5_HUMAN | kinase -> substrate | RegPhos |
| TTK_HUMAN | RBBP5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGR_HUMAN | RBBP5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KSYK_HUMAN | RBBP5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| RBBP5_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0051568 | histone H3-K4 methylation | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0035097 | histone methyltransferase complex | IPI | cellular_component |
| GO:0035064 | methylated histone residue binding | IDA | molecular_function |
| GO:0006974 | response to DNA damage stimulus | IDA | biological_process |
| GO:0042800 | histone methyltransferase activity (H3-K4 specific | IDA | molecular_function |
| GO:0048188 | Set1C/COMPASS complex | IDA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0043627 | response to estrogen stimulus | IDA | biological_process |
| GO:0044212 | transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0071339 | MLL1 complex | IDA | cellular_component |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |