Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:K1C18_HUMAN
Description:keratin 18 [Source:HGNC Symbol;Acc:6430]
Location:chr12 q13.13
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S53VSRSTsFRGGMCaMK_groupRegPhos; SysPTM
S7SFTTRsTFSTNPhosphoSitePlus; RegPhos; SysPTM
S401LDSSNsMQTIQHPRD; RegPhos
S47SGSRIsVSRSTPhosphoSitePlus; HPRD
S53VSRSTsFRGGMCaM-KII_groupphosphoELM; SysPTM
S305RRTVQsLEIDLFilamentPhosphoSitePlus
S242VDAPKsQDLAKFilament; Atg14PhosphoSitePlus
T302TELRRtVQSLEFilamentPhosphoSitePlus
S86KETMQsLNDRLFilament; Atg14PhosphoSitePlus
S127QVRDWsHYFKIHPRD
Y24VQAPSyGARPVPhosphoSitePlus; HPRD
S53VSRSTsFRGGMCAMK2AHPRD; SysPTM
S420DGKVVsETNDTCD99L2PhosphoSitePlus
Y36SAASVyAGAGGPhosphoSitePlus; HPRD; RegPhos
S53VSRSTsFRGGMCaMK2_groupRegPhos; SysPTM
S401LDSSNsMQTIQCD99L2PhosphoSitePlus
S10TRSTFsTNYRSPhosphoSitePlus; HPRD; SysPTM
S177LAMRQsVENDIFilament; Atg14PhosphoSitePlus
T409TIQKTtTRRIVCD99L2PhosphoSitePlus
S305RRTVQsLEIDLHPRD
S398GDALDsSNSMQHPRD; phosphoELM
S49SRISVsRSTSFPhosphoSitePlus; HPRD
Y363RQAQEyEALLNFilamentPhosphoSitePlus
T8FTTRStFSTNYPhosphoSitePlus; HPRD; RegPhos
Y13TFSTNyRSLGSPhosphoSitePlus; HPRD; phosphoELM
S53VSRSTsFRGGMp70S6KbphosphoELM; RegPhos; SysPTM
S53VSRSTsFRGGMCaMK1aRegPhos; SysPTM
S53VSRSTsFRGGMPRKCEHPRD; SysPTM
S53VSRSTsFRGGMPRKCAHPRD; SysPTM
S7FSTNHPRD; phosphoELM; SysPTM
Y129RDWSHyFKIIEFilament; Atg14PhosphoSitePlus
S53VSRSTsFRGGMRPS6KA3HPRD; SysPTM
Y94DRLASyLDRVRFilament; Atg14PhosphoSitePlus
S53VSRSTsFRGGMPKC_groupphosphoELM; RegPhos; SysPTM
S53VSRSTsFRGGMAurA(STK6RegPhos; SysPTM
S177LAMRQsVENDIHPRD
T65SGGLAtGIAGGPhosphoSitePlus; HPRD; SysPTM
S30GARPVsSAASVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S34VSSAAsVYAGACDK1HPRD; SysPTM
S53VSRSTsFRGGMCaM-KI_alphaphosphoELM; SysPTM
S23SVQAPsYGARPPhosphoSitePlus; HPRD
S53VSRSTsFRGGMPhosphoSitePlus; SysPTM
S18YRSLGsVQAPSPhosphoSitePlus; HPRD; RegPhos
S127QVRDWsHYFKIFilament; Atg14PhosphoSitePlus
T192KVIDDtNITRLFilament; Atg14PhosphoSitePlus
T425SETNDtKVLHPRD
S398GDALDsSNSMQCD99L2PhosphoSitePlus
S51ISVSRsTSFRGPhosphoSitePlus; HPRD
S100LDRVRsLETENHPRD
S93NDRLAsYLDRVFilament; Atg14PhosphoSitePlus
S53VSRSTsFRGGMCaMK2aRegPhos; SysPTM
S44AGGSGsRISVSHPRD
T11RSTFStNYRSLPhosphoSitePlus; HPRD; RegPhos
S53VSRSTsFRGGMPKCe(PKC epsilonRegPhos; SysPTM
S110NRRLEsKIREHFilament; Atg14PhosphoSitePlus
Y168DFRVKyETELAFilament; Atg14PhosphoSitePlus
T302TELRRtVQSLEHPRD
S399DALDSsNSMQTCD99L2PhosphoSitePlus; SysPTM
T195DDTNItRLQLEFilament; Atg14PhosphoSitePlus
S53VSRSTsFRGGMRSK2RegPhos; SysPTM
S60RGGMGsGGLATPhosphoSitePlus; HPRD; RegPhos; SysPTM
S319RNLKAsLENSLFilamentPhosphoSitePlus
S34VSSAAsVYAGACDC2RegPhos; SysPTM
T404SNSMQtIQKTTHPRD; RegPhos
T379EAEIAtYRRLLFilament; CD99L2PhosphoSitePlus
S53VSRSTsFRGGMPKCeRegPhos; SysPTM
S53VSRSTsFRGGMPKCaRegPhos; SysPTM
T201RLQLEtEIEALFilament; Atg14PhosphoSitePlus
Y270EELDKyWSQQIFilamentPhosphoSitePlus
S100LDRVRsLETENFilament; Atg14PhosphoSitePlus
S34VSSAAsVYAGAPhosphoSitePlus; phosphoELM; SysPTM
Y256DIRAQyDELARFilament; Atg14PhosphoSitePlus
S53VSRSTsFRGGMPKC_epsilonphosphoELM; SysPTM
S15STNYRsLGSVQPhosphoSitePlus; HPRD; RegPhos
Y331EVEARyALQMEFilamentPhosphoSitePlus
T52SVSRStSFRGGHPRD
S31ARPVSsAASVYPhosphoSitePlus; HPRD; RegPhos
S399DALDSsNSMQTHPRD; SysPTM
S42AGAGGsGSRISPhosphoSitePlus; HPRD; RegPhos; SysPTM
S319RNLKAsLENSLHPRD
T404SNSMQtIQKTTCD99L2PhosphoSitePlus
S420DGKVVsETNDTHPRD
S34VSSAAsVYAGACDC2(CDK1RegPhos; SysPTM

Dephosphorylation site
K1C18_HUMAN do not have dephosphorylation site.

Mutation site
K1C18_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000373489Non-small cell lung carcinomaMetastasiscell lineUp17537172
ENSP00000373489hepatitis C virusNormal vs. CancertissueDown0.218715028
ENSP00000373489Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.4218646787
ENSP00000373489Breast CancerTreatment (none vs. SEL1L treatment)cell lineDown0.0915880780
ENSP00000373489Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000373489follicular thyroid carcinomaNormal vs. CancertissueUp1.818316623
ENSP00000373489breast ductal carcinomaNormal vs. CancertissueUp18482919
ENSP00000373489Breast CancerTreatment (none vs. multidrug resistant)cell lineUp1.816540677
ENSP00000373489Breast CancerNormal vs. Cancercell lineUp7.716596714
ENSP00000373489Hepatocellular CarcinomaNormal vs. CancertissueDown18571811
ENSP00000373489Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000373489Gastric CancerTreatment (none vs. 5-fluorouracil treatment)cell lineDown0.216900703
ENSP00000373489Gastric CancerCancer vs. Cancer (good vs. proo survival)tissueDown0.2318830628
ENSP00000373489Gastric CancerNormal vs. CancertissueDown0.2519330469
ENSP00000373489breast ductal carcinomaNormal vs. CancertissueUp18564057
ENSP00000373489Ovarian CancerMetastasiscell lineDown0.2917892554
ENSP00000373489Gastric CancerNormal vs. Cancercell lineUp3.120812763
ENSP00000373489Gastric CancerNormal vs. Cancercell lineUp7.720812763
ENSP00000373489Pancreatic CancerNormal vs. CancertissueUp1.819199705

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S53ISVSRSTsFRGGMGShepatitis B20334631PhosphoSitePlus
S34RPVSSAAsVYAGAGGhepatitis B20334631PhosphoSitePlus
Y13RSTFSTNyRSLGSVQcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KS6B2_HUMANK1C18_HUMANkinase -> substrateRobert H Newman (2013)
KS6A3_HUMANK1C18_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANK1C18_HUMANkinase -> substrateRegPhos
KPCA_HUMANK1C18_HUMANkinase -> substrateHPRD
KCC4_HUMANK1C18_HUMANkinase -> substrateRobert H Newman (2013)
CDK1_HUMANK1C18_HUMANkinase -> substrateHPRD; RegPhos
KCC2A_HUMANK1C18_HUMANkinase -> substrateHPRD
KPCE_HUMANK1C18_HUMANkinase -> substrateHPRD
SP1_HUMANK1C18_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05130Pathogenic Escherichia coli infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005730nucleolusIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0034451centriolar satelliteIDAcellular_component
GO:0045095keratin filamentIEAcellular_component
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0005198structural molecule activityIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005882intermediate filamentIDAcellular_component
GO:0033209tumor necrosis factor-mediated signaling pathwayIEAbiological_process
GO:0043000Golgi to plasma membrane CFTR protein transportIDAbiological_process
GO:0009653anatomical structure morphogenesisTASbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0045095keratin filamentIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0019048virus-host interactionIEAbiological_process
GO:0097110scaffold protein bindingIPImolecular_function
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0005882intermediate filamentIEAcellular_component
GO:0007049cell cycleIEAbiological_process
GO:0005815microtubule organizing centerIDAcellular_component


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