| UniProt/SwissProt ID: | UBE2A_HUMAN |
| Description: | ubiquitin-conjugating enzyme E2A [Source:HGNC Symbol;Acc:12472] |
| Location: | chrX q24 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S120 | EPNPNsPANSQ | CDK2 | HPRD; phosphoELM; RegPhos |
| S120 | EPNPNsPANSQ | CDK1 | HPRD; phosphoELM |
| S45 | EPNPNsPANSQ | CDK1 | HPRD |
| S120 | EPNPNsPANSQ | UQ_con | PhosphoSitePlus |
| S120 | EPNPNsPANSQ | CDC2 | RegPhos |
| S90 | EPNPNsPANSQ | CDK2 | HPRD |
| S90 | EPNPNsPANSQ | CDK1 | HPRD |
| S45 | EPNPNsPANSQ | CDK2 | HPRD |
| S120 | EPNPNsPANSQ | CDC2(CDK1 | RegPhos |
| Dephosphorylation site |
| UBE2A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000360624 | *78Y | COSMIC | Hepatocellular Carcinoma | 21822264 |
| Differential expressed protein |
| UBE2A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| UBE2A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK5_HUMAN | UBE2A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK08_HUMAN | UBE2A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TGFR2_HUMAN | UBE2A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK1_HUMAN | UBE2A_HUMAN | kinase -> substrate | HPRD; RegPhos |
| BMX_HUMAN | UBE2A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK01_HUMAN | UBE2A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1E_HUMAN | UBE2A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BUB1_HUMAN | UBE2A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK2_HUMAN | UBE2A_HUMAN | kinase -> substrate | HPRD; RegPhos |
| GSK3B_HUMAN | UBE2A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04120 | Ubiquitin mediated proteolysis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0051865 | protein autoubiquitination | IDA | biological_process |
| GO:0001701 | in utero embryonic development | IEA | biological_process |
| GO:0006511 | ubiquitin-dependent protein catabolic process | NAS | biological_process |
| GO:0000785 | chromatin | ISS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0033503 | HULC complex | IDA | cellular_component |
| GO:0006281 | DNA repair | IGI | biological_process |
| GO:0008284 | positive regulation of cell proliferation | IDA | biological_process |
| GO:0060135 | maternal process involved in female pregnancy | IEA | biological_process |
| GO:0001741 | XY body | IEA | cellular_component |
| GO:0006301 | postreplication repair | NAS | biological_process |
| GO:0002474 | antigen processing and presentation of peptide ant | TAS | biological_process |
| GO:0000790 | nuclear chromatin | IEA | cellular_component |
| GO:0070936 | protein K48-linked ubiquitination | IDA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016881 | acid-amino acid ligase activity | IEA | molecular_function |
| GO:0000209 | protein polyubiquitination | TAS | biological_process |
| GO:0000785 | chromatin | IEA | cellular_component |
| GO:0070979 | protein K11-linked ubiquitination | IDA | biological_process |
| GO:0031625 | ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0033522 | histone H2A ubiquitination | IDA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0009411 | response to UV | IGI | biological_process |