Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MCM4_HUMAN
Description:minichromosome maintenance complex component 4 [Source:HGNC Symbol;Acc:6947]
Location:chr8 q11.21
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S26AQTPRsEDARSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S13PSRRGsRRGRAPhosphoSitePlus
Y92SSPLTyGTPSSPhosphoSitePlus
Y459RKPDIyERLASMCMPhosphoSitePlus
S31SEDARsSPSQRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S784GIVDIsILTTGPhosphoSitePlus
S34ARSSPsQRRRGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S32EDARSsPSQRRCDK2HPRD; phosphoELM; RegPhos; SysPTM
S32EDARSsPSQRRCDK1HPRD; SysPTM
T7SSPAStPSRRGPhosphoSitePlus; RegPhos
T19RRGRAtPAQTPCDC2RegPhos
T102SRVEGtPRSGVPhosphoSitePlus; HPRD; phosphoELM
Y524LLQYVyNLVPRMCMPhosphoSitePlus
T110SGVRGtPVRQRCDK1HPRD; SysPTM
Y193ITEPLyMQRLGHPRD
T110SGVRGtPVRQRCDK2HPRD; phosphoELM; RegPhos; SysPTM
S87LDFDVsSPLTYPhosphoSitePlus
S326RIAEPsVCGRCHPRD; phosphoELM; RegPhos; SysPTM
Y394NVTGIyRAVPIPhosphoSitePlus; HPRD
S6PSRRHPRD
S88DFDVSsPLTYGCDK1HPRD
S71DVLFSsPPQMHPhosphoSitePlus
T19RRGRAtPAQTPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S3___MSsPASTPPhosphoSitePlus
S3MSSPAsTPCDK2RegPhos
T91VSSPLtYGTPSPhosphoSitePlus
T7SRRGCDK1HPRD
T110SGVRGtPVRQRCDC2RegPhos; SysPTM
S3ASTPCDK2HPRD
T7SSPAStPSRRGCDK2RegPhos
S88DFDVSsPLTYGPhosphoSitePlus
T7SSPAStPSRRGCDC2RegPhos
S120RPDLGsAQKGLPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T7SRRGHPRD; phosphoELM
S145VASEQsLGQKLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S3MSSPAsTPRegPhos
T53LQPMPtSPGVDPhosphoSitePlus; HPRD
T94PLTYGtPSSRVPhosphoSitePlus
S54QPMPTsPGVDLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S54QPMPTsPGVDLCHK1phosphoELM; RegPhos
T110SGVRGtPVRQRPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y522SQLLQyVYNLVMCMPhosphoSitePlus
T488QLFGGtRKDFSMCMPhosphoSitePlus
S78PQMHSsAIPLDPhosphoSitePlus
S131QVDLQsDGAAAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y714ALIEAyVDMRKMCMPhosphoSitePlus
T7SRRGCDK2HPRD
S2____MsSPASTPhosphoSitePlus
S736PRQLEsLIRLAMCMPhosphoSitePlus
S54QPMPTsPGVDLCDK2HPRD; phosphoELM; RegPhos
S736PRQLEsLIRLAHPRD
S105EGTPRsGVRGTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S3ASTPHPRD
S2PASTHPRD
T788ISILTtGMSATPhosphoSitePlus
S32EDARSsPSQRRCDC2RegPhos; SysPTM
S88DFDVSsPLTYGCDC2RegPhos
S142EDIVAsEQSLGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T23ATPAQtPRSEDPhosphoSitePlus; HPRD; phosphoELM
T19RRGRAtPAQTPCDK2HPRD; RegPhos
T19RRGRAtPAQTPCDK1HPRD
S32EDARSsPSQRRPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S9PASTPsRRGSRPhosphoSitePlus
S406VNPRVsNVKSVPhosphoSitePlus; HPRD
S61GVDLQsPAAQDPhosphoSitePlus
S326RIAEPsVCGRCHypA; Elf1PhosphoSitePlus; SysPTM

Dephosphorylation site
MCM4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262105D511NTCGAOvarian Cancer21720365, 18772890
ENSP00000262105R428HTCGAOvarian Cancer21720365, 18772890
ENSP00000430194R428HTCGAOvarian Cancer21720365, 18772890
ENSP00000262105A834TCOSMICMelanoma
ENSP00000262105D511NCOSMICOvarian Cancer21720365
ENSP00000262105G364RCOSMICMelanoma
ENSP00000430194G364RCOSMICMelanoma
ENSP00000430194D511NCOSMICOvarian Cancer21720365
ENSP00000430194D511NTCGAOvarian Cancer21720365, 18772890
ENSP00000430194A834TCOSMICMelanoma
ENSP00000430194R428HCOSMICOvarian Cancer21720365
ENSP00000262105R428HCOSMICOvarian Cancer21720365

Differential expressed protein
MCM4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MCM4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK2_HUMANMCM4_HUMANkinase -> substrateRegPhos
CHK1_HUMANMCM4_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANMCM4_HUMANkinase -> substrateRegPhos
CDK1_HUMANMCM4_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03030DNA replication
hsa04110Cell cycle

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000075cell cycle checkpointTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0015979photosynthesisIEAbiological_process
GO:0006270DNA replication initiationIEAbiological_process
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0006268DNA unwinding involved in replicationIEAbiological_process
GO:0003697single-stranded DNA bindingIEAmolecular_function
GO:0016851magnesium chelatase activityIEAmolecular_function
GO:0006260DNA replicationNASbiological_process
GO:0000216M/G1 transition of mitotic cell cycleTASbiological_process
GO:0015995chlorophyll biosynthetic processIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0003678DNA helicase activityIEAmolecular_function
GO:0000278mitotic cell cycleTASbiological_process
GO:0016887ATPase activityIEAmolecular_function
GO:0042555MCM complexIDAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0006271DNA strand elongation involved in DNA replicationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0004003ATP-dependent DNA helicase activityIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function


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