Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:K2C8_HUMAN
Description:keratin 8 [Source:HGNC Symbol;Acc:6446]
Location:chr12 q13.13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T416IHTKTtSGYAGTraCPhosphoSitePlus
S74NQSLLsPLVLEErk1RegPhos; SysPTM
S37RISSSsFSRVGPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S449GSGAGsSSFSRPhosphoSitePlus
S400LEGEEsRLESGHPRD; phosphoELM; SysPTM
T303DDLRRtKTEISFilament; Fib_alpha; E2R1PhosphoSitePlus
S432YGGLTsPGLSYPhosphoSitePlus; phosphoELM; SysPTM
S251LSMDNsRSLDMFilament; Myosin_tail_1; PhosphoSitePlus; SysPTM
T431AYGGLtSPGLSPhosphoSitePlus; HPRD; phosphoELM
S417HTKTTsGYAGGTraCPhosphoSitePlus
S450SGAGSsSFSRTPhosphoSitePlus
S478LVSESsDVLHPRD; phosphoELM; SysPTM
T305LRRTKtEISEMFilament; Fib_alpha; E2R1PhosphoSitePlus
S253MDNSRsLDMDSHPRD; phosphoELM; RegPhos; SysPTM
S315MNRNIsRLQAEHPRD
S330KGQRAsLEAAIFilament; Fib_alpha; E2R1PhosphoSitePlus; SysPTM
S74NQSLLsPLVLEPKCd(PKC deltaRegPhos; SysPTM
Y228FLRQLyEEEIRFilament; Myosin_tail_1; PhosphoSitePlus
S9RVTQKsYKVSTPhosphoSitePlus; HPRD; RegPhos
S74NQSLLsPLVLEMAPK8HPRD; phosphoELM; SysPTM
S74NQSLLsPLVLEMAPK3HPRD; SysPTM
S74NQSLLsPLVLEMAPK1HPRD; SysPTM
Y204DVDEAyMNKVEFilament; Myosin_tail_1; PhosphoSitePlus
S104NNKFAsFIDKVHPRD; SysPTM
S74NQSLLsPLVLEErk2RegPhos; SysPTM
Y437SPGLSySLGSSPhosphoSitePlus; HPRD; phosphoELM
S432YGGLTsPGLSYErk1RegPhos; SysPTM
Y282EAESMyQIKYEFilament; Fib_alpha; E2R1PhosphoSitePlus
S43FSRVGsSNFRGPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S400LEGEEsRLESGFilament; Myosin_tail_1; PhosphoSitePlus; SysPTM
S74NQSLLsPLVLEJNK1(MAPK8RegPhos; SysPTM
S441SYSLGsSFGSGPhosphoSitePlus; HPRD; phosphoELM
S74NQSLLsPLVLEJNK1RegPhos; SysPTM
S410GMQNMsIHTKTTraCPhosphoSitePlus; SysPTM
S35GSRISsSSFSRPhosphoSitePlus; HPRD; phosphoELM
Y391IEIATyRKLLEFilament; Myosin_tail_1; PhosphoSitePlus
S330KGQRAsLEAAIHPRD; phosphoELM; RegPhos; SysPTM
S442YSLGSsFGSGAPhosphoSitePlus; HPRD; phosphoELM
S253MDNSRsLDMDSFilament; Myosin_tail_1; PhosphoSitePlus; SysPTM
S456SFSRTsSSRAVPhosphoSitePlus; HPRD
S436TSPGLsYSLGSPhosphoSitePlus; HPRD; phosphoELM
S74NQSLLsPLVLEp38aRegPhos; SysPTM
S44SRVGSsNFRGGPhosphoSitePlus; HPRD; RegPhos; SysPTM
S432YGGLTsPGLSYErk1(MAPK3RegPhos; SysPTM
S453GSSSFsRTSSSPhosphoSitePlus
Y267EVKAQyEDIANHPRD; phosphoELM
S432YGGLTsPGLSYMAPK_groupRegPhos; SysPTM
S251LSMDNsRSLDMHPRD; phosphoELM; SysPTM
S410GMQNMsIHTKTHPRD; phosphoELM; SysPTM
T64GMGGItAVTVNIncAPhosphoSitePlus
Y228FLRQLyEEEIRHPRD
S74NQSLLsPLVLEMAPK_groupRegPhos; SysPTM
T26SSRSYtSGPGSPhosphoSitePlus; HPRD; RegPhos
S280RAEAEsMYQIKFilament; Myosin_tail_1; PhosphoSitePlus
S243QISDTsVVLSMHPRD; phosphoELM
S291YEELQsLAGKHFilament; Fib_alpha; E2R1PhosphoSitePlus
Y286MYQIKyEELQSFilament; Fib_alpha; E2R1PhosphoSitePlus
S432YGGLTsPGLSYCDK1phosphoELM; SysPTM
S2____MsIRVTQPhosphoSitePlus
T14SYKVStSGPRAHPRD
S240LQSQIsDTSVVHPRD; phosphoELM
S104NNKFAsFIDKVIncA; Fib_alpha; FilamentPhosphoSitePlus; SysPTM
Y419KTTSGyAGGLSPhosphoSitePlus
Y204DVDEAyMNKVEHPRD; phosphoELM
S308TKTEIsEMNRNFilament; Fib_alpha; E2R1PhosphoSitePlus
S258SLDMDsIIAEVFilament; Myosin_tail_1; PhosphoSitePlus; SysPTM
S74NQSLLsPLVLEIncAPhosphoSitePlus; SysPTM
Y267EVKAQyEDIANFilament; Myosin_tail_1; PhosphoSitePlus
S274DIANRsRAEAEHPRD; phosphoELM; SysPTM
S21GPRAFsSRSYTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S13KSYKVsTSGPRPhosphoSitePlus; HPRD; RegPhos
Y179DFKNKyEDEINIncA; Filament; Myosin_taPhosphoSitePlus
S432YGGLTsPGLSYCDC2(CDK1RegPhos; SysPTM
S424YAGGLsSAYGGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S475DGKLVsESSDVPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S274DIANRsRAEAEFilament; Myosin_tail_1; PhosphoSitePlus; SysPTM
S438PGLSYsLGSSFPhosphoSitePlus; HPRD; phosphoELM
Y143NMFESyINNLRIncA; Fib_alpha; FilamentPhosphoSitePlus
S27SRSYTsGPGSRPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S142DNMFEsYINNLIncA; Fib_alpha; FilamentPhosphoSitePlus
S74NQSLLsPLVLEPKC_deltaphosphoELM; SysPTM
S39SSSSFsRVGSSPhosphoSitePlus; HPRD; phosphoELM
S445GSSFGsGAGSSPhosphoSitePlus; HPRD; phosphoELM
Y427GLSSAyGGLTSPhosphoSitePlus; HPRD; phosphoELM
S24AFSSRsYTSGPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S432YGGLTsPGLSYMAPK3HPRD; phosphoELM; SysPTM
S477KLVSEsSDVLHPRD; phosphoELM
S432YGGLTsPGLSYCaMK2_groupRegPhos; SysPTM
S258SLDMDsIIAEVHPRD; phosphoELM; SysPTM
T67GITAVtVNQSLIncAPhosphoSitePlus
S36SRISSsSFSRVPhosphoSitePlus; HPRD; phosphoELM
T89IQAVRtQEKEQIncA; Fib_alpha; Myosin_tPhosphoSitePlus
Y10VTQKSyKVSTSPhosphoSitePlus
S458SRTSSsRAVVVPhosphoSitePlus
Y374RQLREyQELMNFilament; Spc7; Myosin_taPhosphoSitePlus
Y25FSSRSyTSGPGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T187EINKRtEMENEIncA; Filament; Myosin_taPhosphoSitePlus
S74NQSLLsPLVLEp38a(MAPK14RegPhos; SysPTM
S31TSGPGsRISSSPhosphoSitePlus
S478LVSESsDVLPKPhosphoSitePlus; RegPhos; SysPTM
S212KVELEsRLEGLFilament; Myosin_tail_1; PhosphoSitePlus
S417HTKTTsGYAGGRegPhos
S74NQSLLsPLVLEMAPK14HPRD; phosphoELM; SysPTM
T455SSFSRtSSSRAPhosphoSitePlus
S315MNRNIsRLQAEFilament; Fib_alpha; E2R1PhosphoSitePlus
S457FSRTSsSRAVVPhosphoSitePlus
S451GAGSSsFSRTSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S22PRAFSsRSYTSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S34PGSRIsSSSFSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM

Dephosphorylation site
K2C8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000293308E192KCOSMICMelanoma21499247
ENSP00000293308S31ACOSMICHepatocellular Carcinoma21822264

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000293308Non-small cell lung carcinomaMetastasiscell lineUp17537172
ENSP00000293308hepatitis C virusNormal vs. CancertissueDown0.218715028
ENSP00000293308Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.1618646787
ENSP00000293308Pancreatic CancerNormal vs. CancertissueUp2016215274
ENSP00000293308colorectal cancerNormal vs. CancertissueUp6.119098285
ENSP00000293308Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000293308colorectal cancerNormal vs. CancertissueUp5.115924290
ENSP00000293308Hepatocellular CarcinomaNormal vs. CancertissueDown0.1617627933
ENSP00000293308follicular thyroid carcinomaNormal vs. CancertissueDown0.2218316623
ENSP00000293308follicular thyroid carcinomaNormal vs. CancertissueUp1.918316623
ENSP00000293308follicular thyroid carcinomaNormal vs. CancertissueUp2.318316623
ENSP00000293308breast ductal carcinomaNormal vs. CancertissueUp18482919
ENSP00000293308Breast CancerNormal vs. Cancercell lineUp414997480
ENSP00000293308Hepatocellular CarcinomaNormal vs. CancertissueUp18571811
ENSP00000293308hepatitis B virusNormal vs. Cancercell lineDown0.4119626621
ENSP00000293308Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000293308Non-small cell lung carcinomaNormal vs. Cancercell lineUp15359725
ENSP00000293308Small cell lung carcinomaTreatment (none vs. isogenic Doxorubicin-resistant)cell lineDown0.1218654985
ENSP00000293308Gastric CancerNormal vs. CancertissueDown14711373
ENSP00000293308Gastric CancerCancer vs. Cancer (good vs. proo survival)tissueDown0.2618830628
ENSP00000293308Gastric CancerNormal vs. CancertissueDown0.4419330469
ENSP00000293308Breast CancerTreatment (TNF-a-sensitive vs. TNF-a-resistant )cell lineDown19087274
ENSP00000293308Breast CancerNormal vs. Cancercell lineUp1820052998
ENSP00000293308Breast CancerNormal vs. Cancercell lineUp1.720052998
ENSP00000293308Breast CancerMetastasiscell lineDown0.09420052998
ENSP00000293308Breast CancerNormal vs. CancertissueUp2.820087651
ENSP00000293308Breast CancerNormal vs. CancertissueUp2.920087651
ENSP00000293308Breast CancerNormal vs. CancertissueUp9620857901
ENSP00000293308Breast CancerNormal vs. CancertissueDown0.3420857901
ENSP00000293308Breast CancerNormal vs. CancertissueUp28020857901
ENSP00000293308breast ductal carcinomaNormal vs. CancertissueUp18564057
ENSP00000293308Gastric CancerNormal vs. Cancercell lineUp4.120812763
ENSP00000293308Gastric CancerNormal vs. Cancercell lineUp1220812763
ENSP00000293308Pancreatic CancerNormal vs. CancertissueUp219199705

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y204Filament; Myosin_tail_1; DUF1664; Fib_alpha; TPR_MLP1_2; ATG16KKDVDEAyMNKVELEcholangiocellular carcinoma21253578PhosphoSitePlus
Y267Filament; Myosin_tail_1; Fib_alpha; E2R135; Spc7; Myosin_tail_1IAEVKAQyEDIANRScholangiocellular carcinoma21253578PhosphoSitePlus
Y282Filament; Fib_alpha; E2R135; Spc7; Myosin_tail_1RAEAESMyQIKYEELcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
MK14_HUMANK2C8_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CDK1_HUMANK2C8_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANK2C8_HUMANkinase -> substrateRegPhos
KPCD_HUMANK2C8_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANK2C8_HUMANkinase -> substrateHPRD
MK03_HUMANK2C8_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KCC4_HUMANK2C8_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANK2C8_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
K2C8_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0097110scaffold protein bindingIPImolecular_function
GO:0005198structural molecule activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0019048virus-host interactionIEAbiological_process
GO:0005654nucleoplasmIEAcellular_component
GO:0045095keratin filamentIEAcellular_component
GO:0005882intermediate filamentNAScellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0007010cytoskeleton organizationNASbiological_process
GO:0016363nuclear matrixIEAcellular_component